Increasing dielectric loss of a graphene oxide nanoparticle to enhance the microwave thermoacoustic imaging contrast of breast tumor

Yuan, Chang Lai; Qin, Baohua; Qin, Huan; Xing, Da

doi:10.1039/c9nr06549k

Cited by 20 publications

(12 citation statements)

References 55 publications

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“…The widely used microwave absorbers in TA imaging can be basically divided into two major categories according to their microwave loss mechanism. Nanomaterials such as carbon nanotubes, molybdenum disulfide and graphene nanoparticles are selected to be TA contrast agents based on their relatively large dielectric-loss, where the microwave absorption capability can be further improved by constructing charge disequilibrium sites such as defects on these nanomaterials 64 , 65 . The second category microwave absorbers are hysteresis-loss-type nanomaterials and their microwave absorption capability can be achieved by optimizing structure and components to improve their hysteresis losses.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Cancer detection via Galectin-1-targeted Thermoacoustic Imaging: validation in an in vivo heterozygosity model

Qin¹,

Qin²,

Yuan³

et al. 2020

Theranostics

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Purpose: To investigate the feasibility of microwave-induced thermoacoustic imaging (MTAI) in detecting small pancreatic tumors (< 10 mm in diameter) and to complement the limitation of current clinical imaging methods. Methods: A home-made MTAI system composed of a portable antenna and pulsed microwave generator was developed. The thermoacoustic nanoparticles were composed of the galectin-1 antibody for targeting pancreatic tumors and Fe 3 O 4 nanoparticles as microwave absorbers (anti-Gal1-Fe 3 O 4 nanoparticles). The microwave absorption properties of the nanoparticles were measured with a vector network analyzer and the resolving power of MTAI was investigated by imaging excised pancreatic tumors of different sizes (diameters of 1.0 mm, 3.1 mm, 5.0 mm, 7.2 mm). To simulate actual imaging scenarios, an in vivo heterozygosity model was constructed by covering the pancreatic tumors (~ 3 mm in diameter) in BALB/c nude mice with biologic tissue (~ 5 cm in depth). MTAI images of the heterozygosity model were acquired with/without the injection of the anti-Gal1-Fe 3 O 4 nanoparticles and the thermoacoustic contrast from pancreatic tumors was evaluated with Student's paired t test. The data were analyzed with analysis of variance and nonparametric statistics. Results : Following intravenous infusion, anti-Gal1-Fe 3 O 4 nanoparticles efficiently accumulated in the tumor. The MTAI contrast enhancement in pancreatic tumors with anti-Gal1-Fe 3 O 4 nanoparticles was verified in vitro and in vivo . The pancreatic tumors were visible in nude mice examined with MTAI with a mean contrast enhancement ratio of 2.3 ± 0.15 (standard error of the mean) ( P =. 001) at 6 h post-injection of the nanoparticles. MTAI identified tiny pancreatic tumors in deep tissues with high fidelity. Conclusion : MTAI offers deep imaging depth and high contrast when used with anti-Gal1-Fe 3 O 4 nanoparticles. It can identify pancreatic tumors smaller than 5 mm, which is beyond the identification limit size (~10 mm) of other nondestructive clinical imaging methods. Thus, MTAI has great potential as an alternative imaging modality for early pancreatic cancer detection.

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Section: Discussionmentioning

confidence: 99%

Pancreatic Cancer detection via Galectin-1-targeted Thermoacoustic Imaging: validation in an in vivo heterozygosity model

Qin¹,

Qin²,

Yuan³

et al. 2020

Theranostics

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“…Among the exogenous contrast agents that have been reported [18] , [19] , [20] , conductance loss nanoprobe (engineered saline nanodroplet [21] ), dielectric loss nanoprobes ( e.g. rGO [22] , amino acids [23] , WS 2 [24] , etc. ), magnetic loss nanoprobes ( e.g.…”

Section: Introductionmentioning

confidence: 99%

Manganous-manganic oxide nanoparticle as an activatable microwave-induced thermoacoustic probe for deep-located tumor specific imaging in vivo

Zhang

Chen

et al. 2022

Photoacoustics

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“…Compared with MI, TAI has higher spatial resolution due to its resolution is sub-millimeter ( Liu et al, 2022 ). Up to now, TAI studies in the biomedical field have mainly involved the detection of breast cancer and prostate cancer, joint related disease and brain imaging, etc., especially in the early detection of breast cancer has been extensively studied ( Liu et al, 2018 ; Li et al, 2019 ; Yuan et al, 2019 ; Li et al, 2021 ; Zhang et al, 2022 ). To date, there are few studies on TAI in brain disease.…”

Section: Introductionmentioning

confidence: 99%

Microwave-induced thermoacoustic imaging for the early detection of canine intracerebral hemorrhage

Peng

et al. 2022

Front. Physiol.

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Purpose: This study aimed to investigate the feasibility and validation of microwave-induced thermoacoustic imaging (TAI) for the early detection of canine intracerebral hemorrhage.Methods: A TAI system was used to record the thermoacoustic signal (TAS) of canine intracerebral hemorrhage in the study. First, the difference in TAS between deionized water, fresh ex vivo porcine blood and brain tissue was explored. Second, the canine hemorrhagic stroke model was established, and canine brain ultrasound examination and TAI examination were performed before modeling and at 0.5 h, 1 h, 2 h, 3 h, 4 h, 4.5 h, 5 h and 6 h after modeling. Finally, pathology and ultrasound were used as the reference diagnoses to verify the accuracy of the thermoacoustic imaging data.Results: The results showed that significant differences were observed in TASs among deionized water, fresh ex vivo porcine blood and brain tissue. The intensity of the thermoacoustic signal of blood was significantly higher than that of ex vivo porcine brain tissue and deionized water. The intracerebral hemorrhage model of five beagles was successfully established. Hematomas presented hyperintensity in TAI. Considering ultrasound and pathology as reference diagnoses, TAI can be used to visualize canine intracerebral hemorrhage at 0.5 h, 1 h, 2 h, 3 h, 4 h, 4.5 h, 5 h and 6 h after modeling.Conclusion: This is the first experimental study to explore the use of TAI in the detection of intracerebral hemorrhage in large live animals (canine). The results indicated that TAI could detect canine intracerebral hemorrhage in the early stage and has the potential to be a rapid and noninvasive method for the detection of intracerebral hemorrhage in humans.

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Increasing dielectric loss of a graphene oxide nanoparticle to enhance the microwave thermoacoustic imaging contrast of breast tumor

Abstract: Microwave-induced thermoacoustic imaging (MTAI) utilizes the high dielectric contrast of tissues in the microwave range, and, combined with the high resolution of ultrasound imaging, can noninvasively obtain anatomical and functional structure information.

Cited by 20 publications

References 55 publications

Pancreatic Cancer detection via Galectin-1-targeted Thermoacoustic Imaging: validation in an in vivo heterozygosity model

Pancreatic Cancer detection via Galectin-1-targeted Thermoacoustic Imaging: validation in an in vivo heterozygosity model

Manganous-manganic oxide nanoparticle as an activatable microwave-induced thermoacoustic probe for deep-located tumor specific imaging in vivo

Microwave-induced thermoacoustic imaging for the early detection of canine intracerebral hemorrhage

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