Increasing Dopamine and Acetylcholine Levels during Encoding Does Not Modulate Remember or Know Responses during Memory Retrieval in Healthy Aging—a Randomized Controlled Feasibility Study

Vellage, Anne; Müller, Patrick; Graf, Alina; Bunzeck, Nico; Müller, Notger G.

doi:10.1007/s41465-019-00122-x

Cited by 2 publications

(2 citation statements)

References 44 publications

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“…Because the retarded form of galantamine reaches maximum release after ≈4 hours (for more details on pharmacokinetics and pharmacodynamics of galantamine, see Huang and Fu 18 ), the waiting time between drug administration and the experiment was 2 hours. Regarding dosage, our drug treatment (8 mg galantamine) was derived from previous research 19,20 and clinical recommendations for first‐time dosage 21 . Higher doses would have been associated with numerous side effects (e.g., nausea) and, therefore, were not applicable for ethical reasons.…”

Section: Methodsmentioning

confidence: 99%

Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study

Müller

Vellage

Schmicker

et al. 2021

A&D Transl Res & Clin Interv

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Introduction Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders). Current studies show clinical meaningful improvements only in one third of AD patients treated with cholinesterase inhibitors. Methods Here we investigate structural magnetic resonance imaging of the basal forebrain cholinergic system volume (BF vol ) as a potential predictor of cognitive response to a single dose of galantamine in healthy adults (n = 18; 59 to 75 years). Results We observed that the cognitive response to galantamine, more specifically the attention‐dependent filtering performance in a delayed match‐to‐sample working memory task, correlated with BF vol : Only participants with high BF vol showed a significant positive effect of galantamine on the ability to filter out distracting information during the working memory encoding process. Discussion Future studies need to assess whether BF vol may serve as a predictor of the galantamine response in AD patients, too.

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Section: Methodsmentioning

confidence: 99%

Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study

Müller

Vellage

Schmicker

et al. 2021

A&D Transl Res & Clin Interv

Self Cite

View full text Add to dashboard Cite

show abstract

“…Because the retarded form of galantamine reaches maximum release after ≈4 hours (for more details on pharmacokinetics and pharmacodynamics of galantamine, see Huang and Fu 18 ), the waiting time between drug administration and the experiment was 2 hours. Regarding dosage, our drug treatment (8 mg galantamine) was derived from previous research 19,20 and clinical recommendations for first-time dosage. 21 Higher doses would have been associated with numerous side effects (e.g., nausea) and, therefore,…”

Section: Treatmentmentioning

confidence: 99%

Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults: A randomized controlled double‐blinded crossover study

Müller

Vellage

Müller

2020

Alzheimer's & Dementia

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Background Cholinesterase inhibitors (e.g. galantamine) can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s diseases (AD). However, not everyone benefits from this treatment (non‐responders). Current studies show clinical meaningful improvements only in one third of AD patients treated with cholinesterase inhibitors. In this context, predictors of drug response could optimize AD treatment by identifying non‐responders and protect these patients from common adverse side effects. Method Here, we investigate structural MRI of the basal forebrain cholinergic system volume (BFvol) as a potential predictor of cognitive response to a single dose of galantamine in healthy adults (n=18; 59‐75 years). Result We observed that the cognitive response to galantamine, more specifically the attention‐dependent filtering performance in a delayed match‐to‐sample working memory task, correlated with BFvol: Only participants with high BFvol showed a significant positive effect of galantamine on the ability to filter out distracting information during the working memory encoding process. Conclusion Our results indicate that BFvol could be a predictor of galantamine response in healthy elderly. Future studies need to assess whether BFvol may serve as a predictor of the galantamine response in AD patients, too.

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Increasing Dopamine and Acetylcholine Levels during Encoding Does Not Modulate Remember or Know Responses during Memory Retrieval in Healthy Aging—a Randomized Controlled Feasibility Study

Cited by 2 publications

References 44 publications

Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study

Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study

Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults: A randomized controlled double‐blinded crossover study

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