Increasing doses of naloxone hydrochloride by infusion to treat pain due to the thalamic syndrome

Ray, Debanjali; Tai, Yoshiaki

doi:10.1136/bmj.296.6627.969-a

Cited by 11 publications

(7 citation statements)

References 6 publications

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“…The death rate by alcoholism poses a serious threat to the physical and mental health of patients. After drinking, alcohol enters the blood via the blood capillaries of the stomach and small intestines in a short period of time [5]. The alcohol concentration will reach its peak value within 30~45 min, and then be on a downward trend.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the clinical effects of using naloxone hydrochloride in emergency treatments of acute alcoholism

Gou¹,

Peng²,

Yang³

et al. 2018

biomedicalresearch

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Objective: This study aimed to analyse the clinical effects of using naloxone hydrochloride in emergency treatments of acute alcoholism. Methods: A total of 146 patients admitted between August 2015 and August 2017 in the hospital where the author works were divided into control (n=73) and test (n=73) groups using the odd-even method. Routine and naloxene hydrochloride treatments were administered to the control and test groups, respectively. The clinical effects on the two groups were then compared. Results: The overall response rate of the test group was significantly higher (P<0.05) than that of the control group. The test group significantly outperformed the control group in terms of onset, symptom remission, and symptom disappearance times. The two groups were also compared in terms of limbmovement recovery time, the time when GCS rating reaches eight points, and the duration of hospitalization. Similarly, the test group again showed a significantly higher (P<0.05) performance than the control group. Furthermore, the test and control groups were compared in terms of negative response rate, wherein no significant difference (P<0.05) was observed. Conclusions: The use of naloxone hydrochloride in the emergency treatment of acute alcoholism was reliable, effective, and safe. The compound can significantly alleviate the patients' clinical symptoms and shorten the recovery time. Therefore, further clinical application of naloxone hydrochloride should be promoted.

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Section: Discussionmentioning

confidence: 99%

Analysis of the clinical effects of using naloxone hydrochloride in emergency treatments of acute alcoholism

Gou¹,

Peng²,

Yang³

et al. 2018

biomedicalresearch

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“…In a recent report on the effect of naloxone in this condition, the authors quoted only 4 patients.4 Obviously, further controlled clinical studies are required to verify pizotifen's beneficial effect in deafferentation pain, a condition for which no oral therapy with proven benefit at present exists.…”

Section: Discussionmentioning

confidence: 99%

“…I report here on the beneficial effect of pizotifen,6 a 5-hydroxytryptamine (5-HT) antagonist, in 4 elderly patients with deafferentation pain.…”

Section: Introductionmentioning

confidence: 99%

“…The opioid antagonist, naloxone, has been reported to be effective in alleviating thalamic pain. 4 This drug is known to have adverse effects on the cardiovascular system, such as cardiac arrhythmia,5 and is therefore potentially hazardous for the elderly patients. Although a recent study indicates that naloxone is probably safe to use if the dose is increased step by step over several weeks,4 this drug needs to be administered intravenously.…”

Section: Introductionmentioning

confidence: 99%

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Pizotifen in deafferentation pain

Ghose

1989

Postgraduate Medical Journal

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“…Pharmacological treatment with multiple drugs including antidepressant, antiepileptic, and opioid medications can be effective, but treatment is often frustrating to both patients and physicians (Carrieri et al 1998;Holtom 2000;Ray and Tai 1988). Motor cortex stimulation and deep brain stimulation (DBS) are sometimes attempted in select patients; however, outcomes are not as good in the CPSP population as in patients with peripheral neuropathies (Levy et al 1987;Machado et al 2007;Nguyen et al 2000;Plow et al 2012).…”

mentioning

confidence: 99%

Pain anticipatory phenomena in patients with central poststroke pain: a magnetoencephalography study

Gopalakrishnan

Burgess

Lempka

et al. 2016

Journal of Neurophysiology

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Gopalakrishnan R, Burgess RC, Lempka SF, Gale JT, Floden DP, Machado AG. Pain anticipatory phenomena in patients with central poststroke pain: a magnetoencephalography study. J Neurophysiol 116: 1387-1395, 2016. First published June 29, 2016 doi:10.1152/jn.00215.2016.-Central poststroke pain (CPSP) is characterized by hemianesthesia associated with unrelenting chronic pain. The final pain experience stems from interactions between sensory, affective, and cognitive components of chronic pain. Hence, managing CPSP will require integrated approaches aimed not only at the sensory but also the affective-cognitive spheres. A better understanding of the brain's processing of pain anticipation is critical for the development of novel therapeutic approaches that target affectivecognitive networks and alleviate pain-related disability. We used magnetoencephalography (MEG) to characterize the neural substrates of pain anticipation in patients suffering from intractable CPSP. Simple visual cues evoked anticipation while patients awaited impending painful (PS), nonpainful (NPS), or no stimulus (NOS) to their nonaffected and affected extremities. MEG responses were studied at gradiometer level using event-related fields analysis and timefrequency oscillatory analysis upon source localization. On the nonaffected side, significantly greater responses were recorded during PS. PS (vs. NPS and NOS) exhibited significant parietal and frontal cortical activations in the beta and gamma bands, respectively, whereas NPS (vs. NOS) displayed greater activation in the orbitofrontal cortex. On the affected extremity, PS (vs. NPS) did not show significantly greater responses. These data suggest that anticipatory phenomena can modulate neural activity when painful stimuli are applied to the nonaffected extremity but not the affected extremity in CPSP patients. This dichotomy may stem from the chronic effects of pain on neural networks leading to habituation or saturation. Future clinically effective therapies will likely be associated with partial normalization of the neurophysiological correlates of pain anticipation.

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Increasing doses of naloxone hydrochloride by infusion to treat pain due to the thalamic syndrome

Cited by 11 publications

References 6 publications

Analysis of the clinical effects of using naloxone hydrochloride in emergency treatments of acute alcoholism

Analysis of the clinical effects of using naloxone hydrochloride in emergency treatments of acute alcoholism

Pizotifen in deafferentation pain

Pain anticipatory phenomena in patients with central poststroke pain: a magnetoencephalography study

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