The concrete damages of climate change are intensifying, and adaptation efforts of actors around the world are increasing, especially in coastal regions. Recommending adaptation measures for specific regions and sectors and determining long-term strategies for mitigating global climate change is essential for reducing vulnerability to climate change. This research aims to estimate the changes in climatic parameters and thermal comfort zones to determine concrete targets and offer suggestions for sectors affected by possible changes. The changes that will occur until 2100 in the Antalya basin, which is located in the southernmost part of Türkiye and is a significant hub for agricultural production and tourism, were monitored spatially using Discomfort Index (DI) and Effective Temperature taking wind velocity (ETv). The Shared Socioeconomic Pathways (SSP): SSP 245 and SSP 585 predict that the quite cool areas prevailing in the area, according to ETv, will shrink by 24% and 46%, respectively, and the prevailing cold areas, according to DI, will shrink by 45% and 56%, respectively. By 2100, 5% of the area, according to SSP 245, and 25%, according to SSP 585, will turn into hot areas and move away from the comfort level. The fact that critical regions are areas with high vitality in terms of coastal tourism shows the need to prioritize adaptation policies. These discoveries are discussed in the context of critical issues such as water scarcity and food security, contributing to policy-making for effective management by suggesting specific adaptation measures.