Increasing frequency of non-smoking lung cancer: Presentation of patients with early disease to a tertiary institution in the UK

Cufari, Maria Elena; Proli, Chiara; Sousa, Paulo De; Raubenheimer, Hilgardt; Sahaf, May Al; Chavan, Hema; Shedden, L.; Niwaz, Zakiyah; Leung, Maurice P.; Nicholson, Andrew G.; Anikin, Vladimir; Emma, Beddow; McGonigle, Niall; Dusmet, Michael; Jordan, Simon; Ladas, George; Lim, Eric

doi:10.1016/j.ejca.2017.06.031

Cited by 70 publications

(51 citation statements)

References 10 publications

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“…Our sample had an average age of 49.8 years, whereas lung cancer is most prevalent among those aged 71–80 years (British Lung Foundation, ). Compared to the UK lung cancer population, our sample also included a higher self‐reported proportion of non‐smokers (40%, vs. 20%, Cufari et al ., ) and females (69%, vs. 46.2%; Office for National Statistics, ). This raises concerns about generalizability to the lung cancer population and highlights the difficulties in reaching the target population.…”

Section: Discussionmentioning

confidence: 99%

Developing and testing a web‐based intervention to encourage early help‐seeking in people with symptoms associated with lung cancer

Mueller

Davies

Jay

et al. 2018

British J Health Psychol

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The potential for differential dropout in online randomized trials requires careful consideration. Future help-seeking interventions should provide support for those who have previously felt dismissed by health professionals. The feasibility study provides some evidence that our 'TPB components' were effective, but validation in a powered trial is necessary. Statement of contribution What is already known on this subject? People with lung cancer often delay presenting symptoms to health services. Some patients (or their family/friends) look up symptoms online before their diagnosis, to decide whether they should see a doctor. Interventions are needed to ensure people can find useful information online that will encourage them to seek help for relevant symptoms. What does this study add? Theory-mapping and user involvement facilitated systematic intervention development. Lung cancer help-seeking interventions should address salient beliefs and personal relevance. The potential for differential dropout in online randomized trials requires careful consideration.

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Section: Discussionmentioning

confidence: 99%

Developing and testing a web‐based intervention to encourage early help‐seeking in people with symptoms associated with lung cancer

Mueller

Davies

Jay

et al. 2018

British J Health Psychol

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“…One major risk factor of lung cancer is smoking. However, the number of non-smoker patients with lung cancer is reported to have increased (2), which implies the existence of other unknown risk factors (1). Surgery is a key treatment modality for patients with non-metastatic lung cancer.…”

Section: Introductionmentioning

confidence: 99%

Detection of circulating tumor cells in patients with lung cancer using metallic micro‑cavity array filter: A pilot study

et al. 2020

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We have developed a metallic micro-cavity array filter and an automated detection system for capturing circulating tumor cells (CTCs). In this single institutional pilot study, we assessed the ability of this device to detect CTCs in patients with lung cancer at each stage. Patients diagnosed with lung cancer, undergoing planned surgery for lung cancer, or suspected of having lung cancer were recruited (40 recruited and 2 excluded). Blood samples were obtained from the patients and 3 ml whole blood was applied to the device without any preparation. The captured cells were stained to differentiate the nucleus, and determine cytokeratin and CD45 expression. Subsequently, two operators blinded to clinical information counted the number of CTCs. Sample collection was performed at the time of recruitment, before treatment and ~3 months after initial blood collection. CTC counts at recruitment were 1.4±0.4, 1.8±1.2, 1.3±0.6 and 7.4±5.1 (mean ± SE) in clinical stages I, II, III and IV, respectively. No significant difference was observed among the stages. These data indicated the ability of this device to detect CTCs at early or non-metastatic stages of lung cancer. Further research on a larger scale is needed for a more accurate assessment of the device, and research on the utility of captured cells remains a future challenge.

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“…Cerfolio et al (14) described clinical results of nervesparing thoracotomy versus RAS are consecutively: morbidity 38% versus 27%, mortality 3.1% versus 0%, chest drain duration 3.0 days versus 1.5 days, post-operative pain score median and range at 3 weeks 4.4 [0-8] versus 2.5 [0-7] and hospital stay median and range 4.0 [1-67] versus 2.0 [1][2][3][4][5][6][7]. Interestingly, post-operative RAS morbidities are identified as transient atrial fibrillation (12 patients), air leak (10 patients), chylothorax (2 patients), pneumothorax post drain removal (2 patients), subcutaneous emphysema (6 patients) and respiratory distress requiring reintubation (1 patient).…”

Section: Evidence In Thoracic Rasmentioning

confidence: 99%

“…Seminally, Doll & Hill (2) identified a link between smoking and lung carcinoma, however, noted 31.7% of their sample were non-smokers with lung carcinoma. Cufari et al (3) more recently discussed a trend in 'never-smokers' with lung cancer, identifying a 15% increase in lung cancer rates of non-smokers between 2008 and 2014. Interestingly, Cufari et al (3) concluded there is little evidence to attribute the rise to any single cause.…”

Section: Introductionmentioning

confidence: 99%

Working towards clinical effectiveness—a multi-disciplinary approach to robotic surgery

Garbutt

2019

Ann. Cardiothorac. Surg.

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The importance of a multidisciplinary team (MDT) approach to conventional surgical techniques has strong empirical support. The MDT approach to robotic-assisted surgery (RAS) has not been clearly defined, which encourages prospectively poor MDT performance. Poor performance of the MDT approach, allied to the constant evolution of technology-assisted surgery, can generate unacceptable operative and patient outcomes. This review offers a nursing perspective to the complex paradigm of thoracic RAS, demonstrating key indicators to perioperative MDT engagement. This will be achieved by offering a rationale for RAS in pulmonary resection, identifying additional surgeries where utility is demonstrated. Evaluation of the available evidence will synthesize clinical quality indicators, while key strategies in effective MDT development can be summarised. Conclusively, bespoke and experiential knowledge will be shared, based upon the investigatory findings discussed throughout this article. Allied to a recommended developmental framework, this perspective should allow for transfer of knowledge, creation and replication of useful interventions. Lung cancer is an ever-increasing global concern, currently being the co-modal cancer with an estimated 2.09 million cases worldwide. Populations are ageing and with annual global costs of at least $1.16 trillion, effective treatments are required. RAS shows promise in treating large and complex lesions when compared to a video-assisted thoracoscopic surgery (VATS) approach. A critical indicator being enhanced vision and dexterity in comparison to a VATS approach. Economically, RAS has proven to be an expensive technique, however, when initial purchase costs are excluded, intra-operatively, there are ways to narrow the expense gap and make RAS cheaper. When assessing per hospital stay, exclusive of initial purchase cost, RAS is found to be cheaper than open thoracotomy. This article demonstrates that RAS for pulmonary resection has utility for complex lesions where a VATS approach would be unsuitable. Crucially, as with all complex surgery, the MDT must be performed effectively for optimum patient outcomes.

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Increasing frequency of non-smoking lung cancer: Presentation of patients with early disease to a tertiary institution in the UK

Cited by 70 publications

References 10 publications

Developing and testing a web‐based intervention to encourage early help‐seeking in people with symptoms associated with lung cancer

Developing and testing a web‐based intervention to encourage early help‐seeking in people with symptoms associated with lung cancer

Detection of circulating tumor cells in patients with lung cancer using metallic micro‑cavity array filter: A pilot study

Working towards clinical effectiveness—a multi-disciplinary approach to robotic surgery

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