2020
DOI: 10.1136/annrheumdis-2020-217609
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Increasing incidence of autoantibody-negative RA is replicated and is partly explained by an aging population

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Cited by 20 publications
(22 citation statements)
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“…Matthijssen et al have independently assessed the incidence of anticitrullinated peptide antibody (ACPA)-negative and ACPA-positive RA in the Leiden Early Arthritis Cohort. In concordance with our findings, they found increasing incidence of ACPA-negative RA but not ACPA-positive RA 2. Further, Matthijssen et al proposed that ageing of the population can be an important contributor to these trends and estimated that the rate of increase of new ACPA-negative RA cases in the next 20 years will outpace that of ACPA-positive RA (11% vs 2% increase, respectively), thus substantially increasing the prevalence of ACPA-negative RA.…”
supporting
confidence: 91%
“…Matthijssen et al have independently assessed the incidence of anticitrullinated peptide antibody (ACPA)-negative and ACPA-positive RA in the Leiden Early Arthritis Cohort. In concordance with our findings, they found increasing incidence of ACPA-negative RA but not ACPA-positive RA 2. Further, Matthijssen et al proposed that ageing of the population can be an important contributor to these trends and estimated that the rate of increase of new ACPA-negative RA cases in the next 20 years will outpace that of ACPA-positive RA (11% vs 2% increase, respectively), thus substantially increasing the prevalence of ACPA-negative RA.…”
supporting
confidence: 91%
“…Unexpectedly, we observed a significant increase in the percentages of patients developing RA in more recent inclusion periods. This finding is unexplained and as UA is now mostly autoantibody negative, this may relate to the observation that the incidence of ACPA-negative RA has also increased in past decades [ 35 ]. A limitation of our study is that although we did our best to create homogeneous patient groups by retrospectively using the same criteria in an inception-based cohort, unknown or unmeasured selection bias cannot be excluded.…”
Section: Discussionmentioning
confidence: 99%
“…A decline in the incidence of RF positive RA had been already reported in Finland in 1980-2000 (20) and in the Pima indian population (21) and was more recently confirmed in a large US study (22); although not proven, these changes were attributed to public health measures including smoking cessation. In contrast, seronegative RA cases seem to increase (22)(23)(24), possibly due to growing obesity rates and ageing population. Among environmental factors, considerations can be deducted from studies conducted on serum samples, casecontrol studies and metanalyses.…”
Section: Lifestyle and Environmentmentioning
confidence: 96%
“…• Endogeneous and environmental factors contribute to disease pathogenesis, but specific risk factors could differ between seropositive and seronegative RA (18,19,22,23). • Differences in the pathogenic pathways between the two subsets of the disease can be partially captured from the analysis of the synovial tissue (29,30).…”
Section: Take-home Messagesmentioning
confidence: 99%
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