Increasing incidence of iliopsoas abscesses with MRSA as a predominant pathogen

Alonso, Carolyn D.; Barclay, Sam; Tao, Xuguang Grant; Auwaerter, Paul G.

doi:10.1016/j.jinf.2011.05.008

Cited by 21 publications

(31 citation statements)

References 22 publications

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“…5 However, the results of that study had an important selection bias as most of the cases referred did not entail computed tomography (CT) as a diagnostic tool, which could have led to missed diagnoses of PA secondary to skeletal origin. The latest literature includes case series that use CT as an imaging test, with results showing that the frequency of PA secondary to skeletal origin or Crohn's disease are similar to those described by Wong et al [2][3][4] In line with such results, the largest case series published to date 2 conclusively corroborates that PA, having a skeletal origin, is the most prevalent secondary form. On the aetiology of the secondary psoas abscesses…”

supporting

confidence: 54%

“…1 For us this statement comes as a surprise, because their results are in accordance with most series published in recent years, but these have not been included in their references. [2][3][4] Their conclusion does not conform to reality and is influenced by a 1986 study that referred to most PA cases described in publications till that time. 5 However, the results of that study had an important selection bias as most of the cases referred did not entail computed tomography (CT) as a diagnostic tool, which could have led to missed diagnoses of PA secondary to skeletal origin.…”

mentioning

confidence: 93%

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Letter to the Editor: On the aetiology of the secondary psoas abscesses

Tuells

Ros²,

Navarro-López³

2013

Hong Kong Med J

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supporting

confidence: 54%

mentioning

confidence: 93%

Letter to the Editor: On the aetiology of the secondary psoas abscesses

Tuells

Ros²,

Navarro-López³

2013

Hong Kong Med J

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“…As S. aureus remains a leading cause of nosocomial infection worldwide1415, traditional therapy may be insufficient in most patients and antibiotics with novel structure or target must be developed to fight MRSA. Our data showed that five dicoumarin derivatives (BH, NBH, TBH, MBH and MOBH) exerted different anti- S. aureus activities.…”

Section: Discussionmentioning

confidence: 99%

Selective in vivo and in vitro activities of 3,3′-4-nitrobenzylidene-bis-4-hydroxycoumarin against methicillin-resistant Staphylococcus aureus by inhibition of DNA polymerase III

Zhou

Zhang

et al. 2015

Sci Rep

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As the persistent resistance of Staphylococcus aureus to available antibiotics is associated with high infection incidence, mortality rate and treatment cost, novel antibacterial agents with innovative therapeutic targets must be developed. 3,3′-(4-Nitrobenzylidene)-bis-(4-hydroxycoumarin) (NBH), a dicoumarin derivative, was reported to exert antibacterial activity. This study investigated the underlying mechanisms of in vivo and in vitro activities of NBH against S. aureus. NBH exerted bactericidal effects against the tested S. aureus and Staphylococcus epidermidis strains in vitro, with low cytotoxicity and resistance and high plasma stability. NBH also exhibited therapeutic effects in vivo on septicaemic mice. Results of molecular docking and analysis on morphological change, DNA production and polymerase inhibition suggested that DNA polymerase could be the target of NBH. These findings indicated that dicoumarin derivatives, which interfere with DNA replication, could be developed as a potential agent against S. aureus, particularly methicillin-resistant strains.

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“…Primary psoas abscess with S. aureus as the primary pathogen only accounts for 20% of all cases of psoas abscess; the remaining 80% of cases of psoas abscess have been reported to be secondary psoas abscesses from adjacent infectious sources. A previous study found that skeletal infections (48%, 29/61), such as vertebral osteomyelitis (33%), pelvic osteomyelitis (8%), and septic arthritis (7%), were the most frequent source of secondary infections, followed by intra-abdominal infections (23%) [ 3 ]. Although rare, several cases of psoas abscess after spinal fusion have been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Mycotic Abdominal Pseudoaneurysm due to Psoas Abscess after Spinal Fusion

Ryu

Lee

2015

Korean J Thorac Cardiovasc Surg

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A 36-year-old man, who had undergone thoracoscopic anterior spinal fusion using the plate system and posterior screw fusion three months previously, presented to our hospital with left flank pain and fever. Computed tomography indicated the presence of a psoas muscle abscess. However, after two days of percutaneous catheter drainage, a mycotic abdominal aortic pseudoaneurysm was detected via computed tomography. We performed in situ revascularization using a prosthetic graft with omental wrapping. Methicillin-resistant Staphylococcus aureus was identified on blood and pus culture, and systemic vancomycin was administered for one month. Although the abscess recurred, it was successfully treated with percutaneous catheter drainage and systemic vancomycin administration for three months, without the need for instrumentation removal. The patient remained asymptomatic throughout two years of follow-up.

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Increasing incidence of iliopsoas abscesses with MRSA as a predominant pathogen

Cited by 21 publications

References 22 publications

Letter to the Editor: On the aetiology of the secondary psoas abscesses

Letter to the Editor: On the aetiology of the secondary psoas abscesses

Selective in vivo and in vitro activities of 3,3′-4-nitrobenzylidene-bis-4-hydroxycoumarin against methicillin-resistant Staphylococcus aureus by inhibition of DNA polymerase III

Mycotic Abdominal Pseudoaneurysm due to Psoas Abscess after Spinal Fusion

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