Increasing incidence of invasive and in situ cervical adenocarcinoma in the Netherlands during 2004–2013

Horst, Judith van der; Siebers, Albert G.; Bulten, Johan; Massuger, Leon F.A.G.; Kok, Inge Mcm de

doi:10.1002/cam4.971

Cited by 70 publications

(52 citation statements)

References 32 publications

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“…The incidence of uterine cervical adenocarcinoma has been increasing worldwide, predominantly in young women, despite the fact that the incidence of squamous cell carcinoma (SCC) has been decreasing [1] , [2] . It has been shown that adenocarcinoma has a worse prognosis than that of SCC at the same stage and with the same tumor size.…”

Section: Introductionmentioning

confidence: 99%

Estrogen/GPR30 Signaling Contributes to the Malignant Potentials of ER-Negative Cervical Adenocarcinoma via Regulation of Claudin-1 Expression

Akimoto

Takasawa

et al. 2018

Neoplasia

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Cervical adenocarcinomas are believed to lose estrogen response on the basis of no expression of a nuclear estrogen receptor such as ERα in clinical pathology. Here, we demonstrated that cervical adenocarcinoma cells respond to a physiological concentration of estrogen to upregulate claudin-1, a cell surface molecule highly expressed in cervical adenocarcinomas. Knockout of claudin-1 induced apoptosis and significantly inhibited proliferation, migration, and invasion of cervical adenocarcinoma cells and tumorigenicity in vivo. Importantly, all of the cervical adenocarcinoma cell lines examined expressed a membrane-bound type estrogen receptor, G protein–coupled receptor 30 (GPR30/GPER1), but not ERα. Estrogen-dependent induction of claudin-1 expression was mediated by GPR30 via ERK and/or Akt signaling. In surgical specimens, there was a positive correlation between claudin-1 expression and GPR30 expression. Double high expression of claudin-1 and GPR30 predicts poor prognosis in patients with cervical adenocarcinomas. Mechanism-based targeting of estrogen/GPR30 signaling and claudin-1 may be effective for cervical adenocarcinoma therapy.

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Section: Introductionmentioning

confidence: 99%

Estrogen/GPR30 Signaling Contributes to the Malignant Potentials of ER-Negative Cervical Adenocarcinoma via Regulation of Claudin-1 Expression

Akimoto

Takasawa

et al. 2018

Neoplasia

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“…Relativamente à incidência de CCU, tem sido reportada uma diminuição de carcinoma epidermoide mas um aumento de adenocarcinoma. 38 O adenocarcinoma está associado a pior prognóstico 5 e o aumento deste subtipo de CCU pode ser explicado pela maior dificuldade de detetar estas lesões através de exame citológico. 3,5 A base de dados utilizada para esta análise não nos permite averiguar o contributo de cada subtipo histológico de CCU na mortalidade, o que constitui uma limitação deste estudo.…”

Section: Discussionunclassified

Evolução Temporal da Mortalidade por Cancro do Colo do Útero em Portugal

Teixeira¹,

Pereira²,

Anes³

et al. 2019

Acta Med Port

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Introduction: The mortality rate due to cervical cancer is higher in Portugal compared to other European countries. This study aimed to evaluate the time-trends in cervical cancer mortality rates observed in Portugal over the last six decades.Material and Methods: Age-standardized cervical cancer mortality rates reported in Portugal between 1955 and 2014, were collected from the International Agency for Research on Cancer (IARC). Joinpoint regression analysis was used to identify significant changes in mortality rates by assessing the percentage of annual variation (%AV) of the rate and respective 95% confidence interval (95%CI) according to the age groups.Results: Among women with 30–39 years, cervical cancer mortality decreased 1.9% per year (95%CI: –2.3; –1.4) throughout the time-period, reaching 0.5/100 000 in 2014. Among women aged 40–49 years, CC mortality decreased between 1971 and 1981 (%AV = –11.6; IC 95%: –14.6; –8.6). Rates then increased by 2.4% per year (95%CI: 1.0; 3.8) until 2001 and such trend reverted from 2001 onwards (%AV = –5.2; IC 95%: –7.7; –2.6), reaching 3.0/100 000 in 2014. In women aged 50–64, 65–74 and 75 years or older, cervical cancer mortality rates decreased from 29.2 to 6.7/100 000, from 34.3 to 7.7/100 000 and from 24.7 to 9.2/100 000. The decline in mortality rates in these three age groups occurred mainly between 1970 and 1980, and there have been no significant changes in the last three decades.Discussion: In Portugal, the most impressive decline in cervical cancer mortality rates occurred in the 1970s concurrently with changes in the National Healthcare System. The most important changes were the increased access to early diagnosis and the improvement in therapeutic approaches. The plateau that we observed among older women over the last three decades can be partially explained by factors with negative impact on adherence to cervical screening.Conclusion: There was a marked decrease in mortality due to CC among all age groups. However, we observed a plateau of this indicator in more advanced age groups over the last three decades. These findings suggest the need of promoting adherence to cervical screening in Portugal.

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“…[4,44]. Moreover, the portion of adenocarcinoma in cervical cancer is getting higher [46,47]. Therefore, ER-based diagnostics applying to adeno-squamous carcinoma and adenocarcinoma is also rational.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Availability of Estrogen Receptor Alpha mRNA on Cervical Cancer Tissue

Kim

et al. 2018

Korean J Clin Lab Sci.

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Cervical cancer is the fourth most frequently diagnosed cancer in women worldwide. In lower Human Development Index countries, it has the second highest incidence and mortality among cancer in women. Therefore, better diagnosis and treatment systems are needed. Among them, estrogen receptor alpha (ER-) mRNA expression has been analyzed with RT-qPCR since several studies reported that ER- is necessary in the maturation of the uterus and is related to cervical cancer. In this study, ER- quantitative analysis was performed on various lesions and normal tissue samples. Based on the receiver operating characteristic (ROC) curve, its sensitivity and specificity were 85% and 75%, respectively, showing higher or similar results to those of conventional HPV tests. In addition, its expression level was analyzed with clinical information. With regression analysis, the R square value between the ER- mRNA expression level and menopause status was 0.5041, indicating a strong correlation. This study was performed as part of a pilot study and suggests that ER- is related to carcinogenesis. Future studies will examine other hormones and menopausal factors with a larger sample size.

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Increasing incidence of invasive and in situ cervical adenocarcinoma in the Netherlands during 2004–2013

Cited by 70 publications

References 32 publications

Estrogen/GPR30 Signaling Contributes to the Malignant Potentials of ER-Negative Cervical Adenocarcinoma via Regulation of Claudin-1 Expression

Estrogen/GPR30 Signaling Contributes to the Malignant Potentials of ER-Negative Cervical Adenocarcinoma via Regulation of Claudin-1 Expression

Evolução Temporal da Mortalidade por Cancro do Colo do Útero em Portugal

Diagnostic Availability of Estrogen Receptor Alpha mRNA on Cervical Cancer Tissue

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