Increasing Incidence of Korsakoff's Psychosis in the East End of Glasgow

Jauhar, Pramod; Ramayya, Anjali

doi:10.1093/alcalc/33.5.550

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1999

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“…Recently, in the East End of Glasgow, the incidence of Korsakoff's psychosis increased from 12.5 cases per million in 1990 to 81.25 cases per million in 1995, with a malerfemale ratio or 1.5:1 in an area where the alcohol dependence male:female ratio is 3:1, 83 much as had been observed by Victor and colleagues earlier. 13 Heavy endemic alcohol consumption, poor availability of parenteral thiamine, and delayed diagnosis and treatment were surmised to be the etiologies in Glasgow.…”

Section: Resultsmentioning

confidence: 55%

Brain Injury Associated With Chronic Alcoholism

Ragan¹,

Singleton²,

Martin³

1999

CNS spectr.

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Alcoholism can result in a number of severe consequences to the central nervous system, including Korsakoff's psychosis, delusions, delirium, Wernicke's encephalopathy, and cerebellar degeneration. Many of these disorders have a substantially higher prevalence than had been previously believed. Neuropathologic and neuroimaging studies have been instrumental in identifying the changes undergone by the alcoholic brain and the factors that may contribute to alcohol-induced brain damage. Biologic differences appear to make women especially susceptible to central nervous system insult from alcohol abuse. The damage caused by alcohol may be associated, in part, with thiamine deficiency, neuronal excitotoxicity, and magnesium wasting.

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Section: Resultsmentioning

confidence: 55%