Increasing Incidence of Melanoma Among Young Adults: An Epidemiological Study in Olmsted County, Minnesota

Reed, Kurtis B.; Brewer, Jerry D.; Lohse, Christine M.; Bringe, Kariline E.; Pruitt, Crystal N.; Gibson, Lawrence E.

doi:10.1016/j.mayocp.2012.01.010

Cited by 152 publications

(142 citation statements)

References 21 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…[13][14][15] Although studies have highlighted increasing adult melanoma incidence and illuminated likely contributing factors to population trends, no recent studies have specifically focused on childhood and adolescent melanoma incidence. 16 Therefore, our objective was to describe trends in childhood and adolescent melanoma incidence diagnosed between the ages of 0 and 19 years in the United States by gender, stage, age at diagnosis, and primary site for the period 1973 through 2009 by using data from the Surveillance, Epidemiology, and End Results (SEER) database. In addition, we investigated associations with UV exposure levels.…”

mentioning

confidence: 99%

Incidence of Childhood and Adolescent Melanoma in the United States: 1973–2009

Harris²,

et al. 2013

View full text Add to dashboard Cite

WHAT'S KNOWN ON THIS SUBJECT: The incidence of childhood and adolescent melanoma has been significantly increasing up to 2004. Risk factors (fair skin, light-colored hair/eyes, female gender, presence of nevi, family history, increased number of sunburns, and exposure to UV radiation) are associated with melanoma.WHAT THIS STUDY ADDS: This study describes incidence trends of melanoma diagnosed between the ages of 0 and 19 years and from 1973 through 2009 by gender, stage and age at diagnosis, primary site, and exposure to UV radiation. abstract OBJECTIVE: Childhood and adolescent melanoma is rare but has been increasing. To gain insight into possible reasons underlying this observation, we analyzed trends in melanoma incidence diagnosed between the ages of 0 and 19 years among US whites by gender, stage, age at diagnosis, and primary site. We also investigated incidence trends by UV-B exposure levels.METHODS: By using Surveillance, Epidemiology, and End Results (SEER) program data (1973-2009), we calculated age-adjusted incidence rates (IRs), annual percent changes, and 95% confidence intervals for each category of interest. Incidence trends were also evaluated by using joinpoint and local regression models. SEER registries were categorized with respect to low or high UV-B radiation exposure. RESULTS:From 1973 through 2009, 1230 children of white race were diagnosed with malignant melanoma. Overall, pediatric melanoma increased by an average of 2% per year (95% confidence interval, 1.4%-2.7%). Girls, 15-to 19-year-olds, and individuals with low UV-B exposure had significantly higher IRs than boys, younger children, and those living in SEER registries categorized as high UV-B. Over the study period, boys experienced increased IRs for melanoma on the face and trunk, and females on the lower limbs and hip. The only decreased incidence trend we observed was among 15-to 19-yearolds in the high UV-B exposure group from 1985 through 2009. Local regression curves indicated similar patterns.CONCLUSIONS: These results may help elucidate possible risk factors for adolescent melanoma, but additional individual-level studies will be necessary to determine the reasons for increasing incidence trends.

show abstract

mentioning

confidence: 99%

Incidence of Childhood and Adolescent Melanoma in the United States: 1973–2009

Harris²,

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The disease's incidence has been rising by 30-50% every five years, and the increases affect people in all age groups ( Jemal et al, 2010;Reed et al, 2012). The number of patients more than doubled between 1971 and 1990.…”

Section: Discussionmentioning

confidence: 99%

Increased Levels of β-catenin, LEF-1, and HPA-1 Correlate with Poor Prognosis for Acral Melanoma with Negative BRAF and NRAS Mutation in BRAF Exons 11 and 15 and NRAS Exons 1 and 2

Yang

Zhang

et al. 2015

DNA and Cell Biology

View full text Add to dashboard Cite

To determine the expression of b-catenin, lymphoid enhancer-binding protein-1 (LEF-1), and heparanase-1 (HPA-1) and to evaluate these proteins' potential prognostic values in malignant acral melanoma without mutations in BRAF exons 11 and 15 and NRAS exons 1 and 2, specimens from 90 patients with wild-type BRAF and NRAS were assessed and analyzed by immunohistochemistry and western blotting. The positive expression of b-catenin, lymphoid enhancer-binding protein-1, and heparanase-1 was observed in 36 (72%), 31 (62%), and 32 (64%) of the detected acral melanomas, respectively. The expression of b-catenin, lymphoid enhancerbinding protein-1, and heparanase-1 was not correlated with gender, age, or diseased body parts ( p > 0.05), but was significantly positively correlated with the tumor node metastasis (TNM) stage and metastasis (correlation = 0.406 and 0.716, 0.397 and 0.582, 0.353 and 0.579; p = 0.040 and 0.0001, 0.0040 and 0.0001, 0.0120 and 0.0001, respectively). We also observed that the increased expression of b-catenin, lymphoid enhancer-binding protein-1, and heparanase-1 was significantly correlated with decreased survival and poor prognosis ( p = 0.001, 0.010, and 0.023, respectively). A multifactorial analysis using Cox's regression model revealed that b-catenin, lymphoid enhancer-binding protein-1, heparanase-1, and the TNM stage were all independent factors in malignant melanoma (risk ratios were 7.294, 5.550, 5.622, and 4.794; p-values were 0.007, 0.018, 0.018, and 0.029, respectively). This study may provide the basis for the use of b-catenin, lymphoid enhancer-binding protein-1, and heparanase-1 as novel targets in the treatment of malignant invasion and metastasis in acral melanoma cancer. The expression of b-catenin, LEF-1, and HPA-1 was assessed and compared in malignant melanoma with that of peritumoral tissue and benign nevus in the patients with negative mutations in BRAF exons 11 and 15 and NRAS exons 1 and 2. The study may provide the basis for b-catenin, LEF-1, and HPA-1 as new targets in the treatment of malignant invasion and metastasis in melanoma cancer.

show abstract

“…Incidence rates have been increasing in particular in young Caucasian women, with one study showing an eightfold increase from the 1970s to the 2000s. [46] It is thought that this trend is attributable to behavioral risk factors, in particular the use of UV tanning beds.…”

Section: Melanomamentioning

confidence: 99%

Shooting for the moon: using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics

2017

View full text Add to dashboard Cite

Tissue engineering holds great promise for advancing cancer research and achieving the goals of the Cancer Moonshot by providing better models for basic research and testing novel therapeutics. This paper focuses on the use of hydrogel biomaterials due to their unique ability to entrap cells in three-dimensional (3D) matrix that mimics tissues and can be programmed with physical and chemical cues to recreate key aspects of tumor microenvironments. The chemistry of some commonly used hydrogel platforms is discussed, and important examples of their use in tissue engineering 3D cancer models are highlighted. Challenges and opportunities for future research are also discussed.

show abstract

Increasing Incidence of Melanoma Among Young Adults: An Epidemiological Study in Olmsted County, Minnesota

Cited by 152 publications

References 21 publications

Incidence of Childhood and Adolescent Melanoma in the United States: 1973–2009

Incidence of Childhood and Adolescent Melanoma in the United States: 1973–2009

Increased Levels of β-catenin, LEF-1, and HPA-1 Correlate with Poor Prognosis for Acral Melanoma with Negative BRAF and NRAS Mutation in BRAF Exons 11 and 15 and NRAS Exons 1 and 2

Shooting for the moon: using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics

Contact Info

Product

Resources

About