Increasing incidence of multiple sclerosis among women in Buenos Aires: a 22 year health maintenance organization based study

Cristiano, Edgardo; Patrucco, Liliana; Míguez, Jimena; Giunta, Diego; Peroni, José; Rojas, Juan Ignacio

doi:10.1007/s10072-016-2637-3

Cited by 20 publications

(6 citation statements)

References 21 publications

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“…Regarding incidence, we found five studies (French West Indies, Argentina and Panama) that evaluated this issue. 16,19,24,38 Of these five studies, one reported incidence from a period of 16 years that was later extended to 22 years. This study identified an increase in incidence during the follow-up period.…”

Section: Resultsmentioning

confidence: 99%

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Multiple sclerosis epidemiology in Latin America: An updated survey

Cristiano¹,

Rojas

2017

Multiple Sclerosis Journal - Experimental, Translational and Cl

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Novel epidemiological data have appeared in recent years in Latin America (LATAM). The objective of this study was to perform an updated systematic review of the epidemiology of the disease reported in LATAM.MethodsWe conducted a systematic review of published epidemiological articles from January 1995 to December 2016.ResultsIncidence data were found in four studies and ranged from 0.3 to 3 annual cases per 100,000 person-years. Prevalence was reported in 13 studies and ranged from 0.83 to 38.2 cases per 100,000 inhabitants. Two studies showed an increase in prevalence and incidence in the last five years in specific regions.ConclusionThe study provides updated information on epidemiological features of MS in the region. The frequency reported is lower compared with some European and North American countries; however, due to recent observations, studies including follow-up assessment of prevalence and incidence should be conducted in the region.

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Section: Resultsmentioning

confidence: 99%

“…This study identified an increase in incidence during the follow-up period. 38 Incidence values ranged from 0.15 to 3 annual cases per 100,000 person-years (Table 1). Regarding prevalence rates, 13 identified studies assessed prevalence in the region (Table 2).…”

Section: Resultsmentioning

confidence: 99%

Multiple sclerosis epidemiology in Latin America: An updated survey

Cristiano¹,

Rojas

2017

Multiple Sclerosis Journal - Experimental, Translational and Cl

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“…On the other hand, whether MS is an emerging disease among Hispanic individuals is unclear yet appears plausible. This concern has been raised by multiple investigators and is supported by increasing MS incidence and prevalence in selected Latin American countries, 18 particularly Argentina 19 and Puerto Rico. 20 Our findings that MS prevalence is higher among young Hispanic adults than among young White adults yet significantly lower among older Hispanic adults compared to White adults residing in Southern California are consistent with emerging disease hypotheses.…”

Section: Discussionmentioning

confidence: 99%

Racial and Ethnic Disparities in Multiple Sclerosis Prevalence

et al. 2022

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Objective:To determine whether the prevalence of multiple sclerosis (MS) varies by race and ethnicity.Methods:We conducted a retrospective cohort study of more than 2.6 million adults from the multiethnic, community-dwelling members of Kaiser Permanente Southern California. The complete electronic health record of individuals with at least one ICD9 code for MS between January 1, 2008 to December 31, 2010 were reviewed. MS prevalence and 95% confidence intervals (CI) stratified by age-, sex- and race and ethnicity among 2010 members were estimated using binomial regression. Age- and sex-standardized prevalence was estimated according to the 2010 US Census population.Results:We identified 3863 patients with MS. The average age of prevalent MS patients was 51.7 years (standard deviation, 13.1) and 76.8% were women. The female preponderance was more pronounced among Black (81.2%) and Asian (83.6%) than White (76.3%) or Hispanic (74.5%) individuals with MS. Age- and sex-standardized MS prevalence per 100,000 was similarly high among Black (225.8, 95%CI=207.1-244.5) and White (237.7, 95%CI=228.2-247.2) and significantly lower among Hispanic (69.9, 95%CI=64.4-75.5) and Asian persons (22.6, 95%CI=17.1-28.1). MS prevalence was highest between the ages of 35 and 64 years and declined after 65, across all racial and ethnic groups. Among adults ages 18-24, crude MS prevalence was low, but was highest among Black and Hispanic young adults, lower in White and lowest in Asian/PI individuals (48.5, 25.0, 18.0 and 7.1/100,000, respectively).Conclusions:MS prevalence varies by race and ethnicity, being similarly high in White and Black and significantly lower in Hispanic and Asian persons in Southern California. Taken together with previous studies, these findings indicate that the burden of MS in the US Black community has long been under-recognized. More studies are needed to determine whether MS is an emerging disease among US Hispanic adults and whether MS susceptibility and prevalence vary among Hispanic or Asian individuals from different cultures and/or ancestral backgrounds.

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“…MS affects individuals worldwide [ 118 ], and the underlying mechanism in disease development remains unclear. MS is a multifactorial disease associated with both genetic and environmental factors, such as vitamin D levels, ultraviolet B (UVB) exposure, Epstein–Barr infections (EBV), pollution, obesity, and smoking, increase the risks of developing MS [ 119 ]. MS is traditionally considered an autoimmune disease associated with T cell activity.…”

Section: Recent Advances In the Treatment Of Neurological Disordermentioning

confidence: 99%

Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

Rahman

Islam

et al. 2022

Biology

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Neurodegenerative diseases are a global health issue with inadequate therapeutic options and an inability to restore the damaged nervous system. With advances in technology, health scientists continue to identify new approaches to the treatment of neurodegenerative diseases. Lost or injured neurons and glial cells can lead to the development of several neurological diseases, including Parkinson’s disease, stroke, and multiple sclerosis. In recent years, neurons and glial cells have successfully been generated from stem cells in the laboratory utilizing cell culture technologies, fueling efforts to develop stem cell-based transplantation therapies for human patients. When a stem cell divides, each new cell has the potential to either remain a stem cell or differentiate into a germ cell with specialized characteristics, such as muscle cells, red blood cells, or brain cells. Although several obstacles remain before stem cells can be used for clinical applications, including some potential disadvantages that must be overcome, this cellular development represents a potential pathway through which patients may eventually achieve the ability to live more normal lives. In this review, we summarize the stem cell-based therapies that have been explored for various neurological disorders, discuss the potential advantages and drawbacks of these therapies, and examine future directions for this field.

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Increasing incidence of multiple sclerosis among women in Buenos Aires: a 22 year health maintenance organization based study

Cited by 20 publications

References 21 publications

Multiple sclerosis epidemiology in Latin America: An updated survey

Multiple sclerosis epidemiology in Latin America: An updated survey

Racial and Ethnic Disparities in Multiple Sclerosis Prevalence

Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

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