Increasing incidence of type 1 diabetes among Hong Kong children and adolescents: The Hong Kong Childhood Diabetes Registry 2008 to 2017

Tung, Joanna Yuet‐ling; Kwan, Elaine; But, Betty Wai Man; Wong, Wilfred Hing‐Sang; Fu, Antony; Pang, Gloria; Tsang, Jennifer Wing-Yan; Yau, Ho-chung; Belaramani, Kiran; Wong, Lap Ming; Wong, Shirley Man‐yee; Lo, P.; Ng, Kwok-leung; Yeung, Wilson; Chan, Kwok Keung; Chan, Angela; Wong, Sammy Wai‐chun; Tay, Ming-Kut; Chung, Jessica; Lee, Ching-yin; Lam, Y.Y.; Cheung, Pik-To

doi:10.1111/pedi.13016

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…Among the four seasons, newly diagnosed T1DM has long been described more commonly in winter, early spring, and late autumn months in Western countries ( 19 ). In a Japanese study, the peak periods of disease onset were spring and winter, which is similar to Hong Kong and southern China ( 16 , 18 ). However, a lack of seasonality was observed in a study from Shanghai ( 20 ).…”

Section: Discussionmentioning

confidence: 87%

“…Previous studies suggested that the incidence in males exceeds that in females in most countries where incidence is high (populations of European origin), but lower than that in females in low incidence countries (Asia and Africa) ( 2 , 15 , 16 ). In China, studies in Zhejiang, Harbin, and Hong Kong also reported a higher incidence in females than in males ( 6 , 17 , 18 ). In our study, the rate ratio of females was 1.32 (95% CI: 1.20, 1.93) in the 0-14 years age group.…”

Section: Discussionmentioning

confidence: 99%

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Incidence of Newly Diagnosed Type 1 Diabetes Mellitus in Children and Adolescents in Henan Province of China from 2017 to 2020: A Retrospective Multicenter Study Based on Hospitalization Data

Chen¹,

Xu²,

Chen³

et al. 2022

Jcrpe

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Objective: The incidence of type 1 diabetes mellitus (T1DM) is rapidly increasing worldwide. However, the incidence in Henan Province of China has been unknown for more than two decades. This study aimed to estimate the incidence of T1DM in the 0.5-14.9 years age group in Henan Province of China from 2017 to 2020. Methods: A retrospective analysis of hospital registration data from 18 cities in Henan Province, China, identified 1726 patients (843 males, 883 females) between 0.5-14.9 years of age with newly diagnosed T1DM in Henan Province from January 1 st , 2017, to December 31 st , 2020, covering more than 19 million children years at risk. Results: The crude incidence of T1DM per 100 000 person years for the 0.5-14.9 years age group in the Henan Province of China was 2.19 [95% confidence interval (CI): 1.99, 2.40], with a peak in the 10-14.9 years age group. The rate ratio of females to males was 1.32 (95% CI: 1.20, 1.45) in the 0.5-14.9 years age group. The incidence rate was higher in females than males in the 5-9.9 years age group (p<0.01) and the 10-14.9 years age group (p<0.01). The seasonality of the incidence was different from that in previous reports, with the lowest incidence in the spring. Conclusion: The incidence of T1DM in the 0.5-14.9 years age group in Henan Province was still among the lowest reported globally, but was in line with other incidence rates reported from China.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Incidence of Newly Diagnosed Type 1 Diabetes Mellitus in Children and Adolescents in Henan Province of China from 2017 to 2020: A Retrospective Multicenter Study Based on Hospitalization Data

Chen¹,

Xu²,

Chen³

et al. 2022

Jcrpe

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“…It included all childhood diabetes diagnosed from 2008 onwards. The methodology on data collection was described previously 8 . In brief, it is a collaborative research project of all pediatric departments in the public health care system in Hong Kong.…”

Section: Methodsmentioning

confidence: 99%

“…The methodology on data collection was described previously. 8 In brief, it is a collaborative research project of all pediatric departments in the public health care system in Hong Kong. It consists of two parts, a retrospective registry that included all childhood diabetes diagnosed from 2008 to 2015, and a prospective part that included all children diagnosed from 2016 onwards.…”

Section: Data Sourcementioning

confidence: 99%

Incidence and clinical characteristics of pediatric‐onset type 2 diabetes in Hong Kong : The Hong Kong childhood diabetes registry 2008 to 2017

et al. 2021

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Objective: With increasing prevalence of childhood obesity worldwide, the incidence of pediatric-onset type 2 diabetes (T2D) is also increasing in many countries. We aim to analyze the time trend and incidence of T2D in children in Hong Kong from 2008 to 2017, and to characterize clinical characteristics at diagnosis. Methods: Data were retrieved from the Hong Kong Childhood Diabetes Registry. All children with T2D diagnosed at the age of less than 18 years from January 1, 2008 to December 31, 2017 and managed in the public health care system were included in this study.Results: In the incident years of 2008-2017 period, 391 children were diagnosed with T2D. The crude incidence rate was 3.42 per 100,000 persons/year [95% confidence interval (CI) 3.08-3.76], which was much higher than that in last registry of 1.27 per 100,000 persons/year in 1997-2007 (P < 0.001).Most children (76%) were

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“…The peak age for T1DM diagnosis is 5-9yrs and 10-14yrs 1,2 . The prevalence of T1DM is rising among the young population [3][4][5][6] . Patient with recently diagnosed T1DM generally have a lower body mass index; however, prevalence of obesity has increased among these patients during the recent decades 7 .…”

Section: Introductionmentioning

confidence: 99%

Surrogate markers of metabolic syndrome (MetS) and insulin resistance (IR) in children and young adults with type 1 diabetes: A systematic review & meta-analysis

Khandagale

Kamble

Oza

et al. 2023

Preprint

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Introduction: Metabolic syndrome (MetS), a collection of risk factors for cardiovascular disease, and Insulin resistance (IR) are associated with diabetes. The diagnosis of both these conditions are based on specific clinical parameters. However, the efficacy of these parameters has not been systematically studied in paediatric population with T1DM. Methodology: We performed a systematic review and meta-analysis in paediatric populations of type 1 diabetes. We assessed the strength of association of the parameters of MetS and IR. The meta-analysis was performed using a metaphor package in R. A random effect model was used to study the strength of association by estimating Hedges g. Results: The systematic review resulted in identification of 30 studies on MetS and IR in paediatric patients with T1DM. Insulin dosage and HbA1C, markers for glycaemic condition showed no association with MetS in patients with T1DM. In the lipid profile, increased triglyceride (TG) and low-density lipoprotein (LDL) showed better effect size than reduced high-density lipoprotein (HDL). In case of insulin resistance, heterogeneous nature of studies made it difficult to carry out a meta-analysis. A descriptive review of existing and novel markers is thus provided. Conclusion: Lack of association between markers of glycaemic condition suggested that MetS may develop independently of glycaemic control in children with T1DM. Other than TG and HDL, LDL may be used in the diagnosis of MetS. From the descriptive analysis it could be observed that a standard protocol for the diagnosis of IR is needed.

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Increasing incidence of type 1 diabetes among Hong Kong children and adolescents: The Hong Kong Childhood Diabetes Registry 2008 to 2017

Cited by 9 publications

References 28 publications

Incidence of Newly Diagnosed Type 1 Diabetes Mellitus in Children and Adolescents in Henan Province of China from 2017 to 2020: A Retrospective Multicenter Study Based on Hospitalization Data

Incidence of Newly Diagnosed Type 1 Diabetes Mellitus in Children and Adolescents in Henan Province of China from 2017 to 2020: A Retrospective Multicenter Study Based on Hospitalization Data

Incidence and clinical characteristics of pediatric‐onset type 2 diabetes in Hong Kong : The Hong Kong childhood diabetes registry 2008 to 2017

Surrogate markers of metabolic syndrome (MetS) and insulin resistance (IR) in children and young adults with type 1 diabetes: A systematic review & meta-analysis

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