Increasing influenza vaccine uptake in children: A randomised controlled trial

Yeung, Karene Hoi Ting; Tarrant, Marie; Chan, Kate Ching Ching; Tam, Wing Hung

doi:10.1016/j.vaccine.2018.07.066

Cited by 14 publications

(12 citation statements)

References 19 publications

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“…13,14 Even in high-income countries, misperceptions about the risk of severe influenza during infancy might be associated with the underuse of influenza vaccination during pregnancy 15,16 and among infants aged 6 months and older. 17 In this prospective study, 18 we aimed to assess the frequency of influenza virus infection among infants aged younger than 1 year who were admitted to hospital in four middleincome countries. Here, we report the frequency of influenza virus infections identified by serological detection among infants who were influenza-negative by traditional molecular methods, describe the proportion of influenza virus infections that did not present as an acute respiratory illness, and report the frequency of influenza confirmed by real-time RT-PCR (rRT-PCR) among non-ill infants enrolled during the study period from the same communities.…”

Section: Introductionmentioning

confidence: 99%

Underdetection of laboratory-confirmed influenza-associated hospital admissions among infants: a multicentre, prospective study

Thompson

Levine

Bino

et al. 2019

The Lancet Child & Adolescent Health

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Background-Since influenza often presents non-specifically in infancy, we aimed to assess the extent to which existing respiratory surveillance platforms might underestimate the frequency of severe influenza disease among infants.Methods-The Influenza and Respiratory Syncytial Virus in Infants (IRIS) study was a prospective observational study done at four hospitals in Albania, Jordan, Nicaragua, and the Philippines. We included acutely ill infants aged younger than 1 year admitted to hospital within 10 days or less of illness onset during two influenza seasons (2015-16 and 2016-17) in Albania, Jordan, and Nicaragua, and over a continuous 34 week period in the Philippines. We assessed the frequency of influenza virus infections by real-time RT-PCR (rRT-PCR) and serology. The main study outcome was seroconversion, defined as convalescent antibody titres more than or equal to four-fold higher than acute sera antibody titres, and convalescent antibody titres of 40 or higher. Seroconverison was confirmed by haemagglutination inhibition assay for influenza A viruses, and by hemagglutination inhibition assay and microneutralisation for influenza B viruses.Findings-Between June 27, 2015, and April 21, 2017, 3634 acutely ill infants were enrolled, of whom 1943 were enrolled during influenza seasons and had complete acute-convalescent pairs and thus were included in the final analytical sample. Of the 1943 infants, 94 (5%) were influenzapositive by both rRT-PCR and serology, 58 (3%) were positive by rRT-PCR-only, and 102 (5%) were positive by serology only. Seroconversion to at least one of the influenza A or B viruses was observed among 196 (77%) of 254 influenza-positive infants. Of the 254 infants with influenza virus, 84 (33%) only had non-respiratory clinical discharge diagnoses (eg, sepsis, febrile seizures, dehydration, or other non-respiratory viral illness). A focus on respiratory diagnoses and rRT-PCR-confirmed influenza underdetects influenza-associated hospital admissions among infants by a factor of 2•6 (95% CI 2•0-3•6). Findings were unchanged when syndromic severe acute respiratory infection criteria were applied instead of clinical diagnosis. Interpretation-If the true incidence of laboratory-confirmed influenza-associated hospital admissions among infants is at least twice that of previous estimates, this substantially increases the global burden of severe influenza and expands our estimates of the preventive value of maternal and infant influenza vaccination programmes.

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Section: Introductionmentioning

confidence: 99%

Underdetection of laboratory-confirmed influenza-associated hospital admissions among infants: a multicentre, prospective study

Thompson

Levine

Bino

et al. 2019

The Lancet Child & Adolescent Health

View full text Add to dashboard Cite

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“…Overall, recall/reminders for patients and HCP reminders had the highest level of evidence and were the most effective interventions in improving influenza vaccination rates in all high-risk groups and in all types of setting including from primary and tertiary hospitals to large-scale community interventions in the real-world settings. [5][6][7][8][9]15,18,21,[25][26][27][28][29][30][39][40][41]43,50,51 Most reminders identified in this review incorporated educational information to either patients or HCPs. Although, the evidence on whether patient focused educational interventions in improving influenza vaccination uptake is mixed and varies with different target populations, they have shown a positive impact in improving vaccination uptake when administered through different outlets.…”

Section: Discussionmentioning

confidence: 99%

A rapid global review of strategies to improve influenza vaccination uptake in Australia

Mohammed

McMillan

Elliott

et al. 2021

Human Vaccines & Immunotherapeutics

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This study aimed to identify effective strategies for improving the uptake of influenza vaccination and to inform recommendations for influenza vaccination programs in Australia. A rapid systematic review was conducted to assimilate and synthesize peer-reviewed articles identified in PubMed. The National Health and Medical Research Council (NHMRC) Hierarchy of Evidence was used to appraise the quality of evidence. A systematic search identified 4373 articles and 52 that met the inclusion criteria were included. The evidence suggests influenza vaccination uptake may be improved by interventions that (1) increase community/patient demand and access to influenza vaccine and overcome practice-related barriers; (2) reinforce the critical role healthcare providers play in driving influenza vaccination uptake. Strategies such as standing orders, reminder and recall efforts were successful in improving influenza vaccination rates. Community pharmacies, particularly in regional/remote areas, are well positioned to improve influenza vaccine coverage. The findings of this rapid review can be utilized to improve the performance of influenza immunization programs in Australia and other countries with comparable programs; and recommend priorities for future evaluation of interventions to improve influenza vaccination uptake.

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“…In prior studies, targeted, culturally-sensitive outreach campaigns that addressed the specific concerns and needs of communities and that empowered them to make informed health decisions on their own terms were more successful in increasing vaccination rates across groups. 11,[35][36][37][38][39][40] Prior studies have found that groups with higher influenza vaccine coverage have fewer influenza hospitalizations. 20,41 However, in our study, even though SLIV was associated with higher vaccination coverage in Black/African Americans, the incidence of influenza related hospitalizations remained higher than that of other groups.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a city-wide school-located influenza vaccination program in Oakland, California with respect to race and ethnicity: a matched cohort study

Nguyen

Arnold

Kennedy

et al. 2021

Preprint

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Objectives: To evaluate the effectiveness of city-wide school-located influenza vaccination by race/ethnicity from 2014-2018. Methods: We used multivariate matching to pair schools in the intervention district in Oakland, CA with schools in West Contra Costa County, CA, a comparison district. We estimated difference-in-differences (DIDs) in caregiver-reported influenza vaccination coverage and laboratory-confirmed influenza hospitalization incidence. Results: Differences in influenza vaccination coverage in the intervention vs. comparison site were larger among White and Latino students than Asian/Pacific Islander (API), Black, and multiracial students. Concerns about vaccine effectiveness or safety were more common among Black and multiracial caregivers; logistical barriers to vaccination were more common among White, API, and Latinos. In both sites, hospitalization in 2017-18 was higher in Blacks vs. other races/ethnicities. All-age influenza hospitalization incidence was lower in the intervention site vs. comparison site among White/API individuals in 2016-17 and 2017-18 and Black older adults in 2017-18, but not in other groups. Conclusions: SLIV was associated with higher vaccination coverage and lower influenza hospitalization, but associations varied by race/ethnicity. SLIV alone may be insufficient to ensure equitable health outcomes for influenza.

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Increasing influenza vaccine uptake in children: A randomised controlled trial

Cited by 14 publications

References 19 publications

Underdetection of laboratory-confirmed influenza-associated hospital admissions among infants: a multicentre, prospective study

Underdetection of laboratory-confirmed influenza-associated hospital admissions among infants: a multicentre, prospective study

A rapid global review of strategies to improve influenza vaccination uptake in Australia

Evaluation of a city-wide school-located influenza vaccination program in Oakland, California with respect to race and ethnicity: a matched cohort study

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