Increasing Our Knowledge of the Pathogenesis of Fat Embolism

Allardyce, D B; Meek, Robert N.; Woodruff, B. G.; Cassim, M. M.; ELLIS, D.

doi:10.1097/00005373-197411000-00008

Cited by 37 publications

(5 citation statements)

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“…El SEG es más común después de un traumatismo contundente con lesión de huesos largos (Stein, Yaekoub, Matta, & Kleerekoper, 2008). Después de una fractura de la diáfisis femoral, el 98% de los pacientes tienen clínica compatible con EG al momento del ingreso, con la concentración más alta en la circulación venosa que drena el sitio de la fractura (Allardyce, Meek, Woodruff, Cassim, & Ellis, 1974). Durante la fijación de huesos largos de forma quirúrgica, el 88% de los pacientes tienen evidencia ecocardiográfica intraoperatoria de EG circulante (Christie, y otros, 1995).…”

Section: Resultados Epidemiologíaunclassified

“…Estos émbolos pueden ingresar a la circulación venosa y posteriormente alcanzar la circulación pulmonar, afectando a múltiples órganos, incluyendo el cerebro, los riñones, la piel, los ojos y el miocardio. La presentación clínica del SEG suele manifestarse con una tríada de síntomas característicos: dificultad respiratoria, disfunción neurológica y erupción petequial concurrente (Allardyce, Meek, Woodruff, Cassim, & Ellis, 1974). Es importante destacar que el SEG es una condición poco común, pero puede ser potencialmente mortal, especialmente cuando se presenta como consecuencia de un traumatismo ortopédico.…”

Section: Discussionunclassified

“…La epidemiología del SEG muestra una mayor incidencia después de traumatismos ortopédicos, especialmente en fracturas de huesos largos, donde la concentración de émbolos grasos es más alta en la circulación venosa que drena el sitio de la fractura (Chastre, Fagon, & Soler, 1990). La incidencia varía según el tipo y la gravedad del traumatismo, y se ha observado un aumento significativo en pacientes con múltiples fracturas cerradas (Allardyce, Meek, Woodruff, Cassim, & Ellis, 1974); (Butteriss, y otros, 2006). Sin embargo, el SEG también puede ocurrir en otras situaciones clínicas, lo que complica su diagnóstico y tratamiento.…”

Section: Discussionunclassified

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Enfoque Diagnostico del Síndrome de Embolia Grasa, Una Revisión Bibliográfica

Suárez-Villacís,

López-Moya

2024

MQRInvestigar

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Introducción: El síndrome de embolia grasa (SEG) es una condición clínica mal definida atribuida a la entrada de émbolos grasos en la circulación. El SEG ocurre principalmente como consecuencia de un traumatismo ortopédico, y con menos frecuencia a otras condiciones no traumáticas (pancreatitis, anemia de células falciformes, osteomielitis, diabetes mellitus, enfermedad del hígado graso) o después de una intervención iatrogénica (terapia prolongada con corticoides, liposucción). Objetivo: El objetivo de este trabajo es conocer sobre la embolia grasa (EG) y el SEG, y presentar una revisión narrativa enfocada a su diagnóstico abarcando sus definiciones, causas, presentación y tratamiento. Materiales y métodos: Revisión y elección de artículos científicos de diferentes bases de datos (PUBMED, Scopus y MedLine), en inglés. Se incluyeron 26 artículos. Discusión: A pesar de la creciente cantidad de literatura que describe la aparición de SEG, sigue existiendo una incertidumbre clínica significativa con respecto a su diagnóstico, prevención y tratamiento. Conclusiones: Una comprensión más detallada de la patogénesis de este raro síndrome facilitará estrategias específicas para la prevención y el tratamiento. Se necesitan más ensayos clínicos prospectivos de alta calidad para aclarar el papel del tratamiento farmacológico en el SEG.

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Section: Resultados Epidemiologíaunclassified

Section: Discussionunclassified

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Enfoque Diagnostico del Síndrome de Embolia Grasa, Una Revisión Bibliográfica

Suárez-Villacís,

López-Moya

2024

MQRInvestigar

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“…Femoral fractures, particularly segmental femoral fractures, are frequently accompanied by complications, such as hemorrhage 25 , 26 , fat embolism 27 , 28 , knee stiffness 29 , and deep vein thrombosis of the lower extremity 30 . The emergence of any of these complications poses a significant threat to this individual’s life.…”

Section: Discussionmentioning

confidence: 99%

Segmental femoral fracture malunion: evidence and prognostic analysis of medical intervention in the third century BC

Xing,

Zou,

Tang

et al. 2024

Sci Rep

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We examined the remains of an individual who was unearthed from the Tuchengzi site and was believed to be from the Warring States period in China. The remains exhibited segmental femoral fracture. We aimed to deduce the cause of fracture, medical interventions, healing process, and motion behavior after fracture healing using several techniques, including macroscopic observation, computed tomography (CT), and finite element analysis. Based on the morphology of the long bones, it appeared that the individual was male. The fractures resulted in an adduction angle of 5.47° and an anterior flexion angle of 21.34° in the proximal femur, while the femoral neck anteversion angle had been replaced by a retroversion angle of 10.74°. Additionally, the distal femur formed an abnormal anterior convex angle of 144.60°. CT revealed mature callus formation and visible trabecular bundles. The finite element analysis indicated that the maximum von Mises stress in the femur was 17.44 MPa during standing and 96.46 MPa during walking. We suggest that medical practitioners in the Warring States period possessed a good knowledge of thigh anatomy, enabling them to perform fracture reduction and fixation. Reasonable medical intervention facilitated fracture healing and load recovery. Satisfactory fracture healing ensured that the individual could engage in normal standing and walking activities after rehabilitation.

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“…Hence, we posit that the segmental fracture in the present case resulted from either a fall from a horse or a fall from a considerable height during battle. The high prevalence of violent trauma in this region contributed to a high incidence of fracture, subsequently driving the rapid accumulation of knowledge and expertise in fracture treatment among medical practitioners, as well as advancements in medical care.Femoral fractures, particularly segmental femoral fractures, are frequently accompanied by complications, such as hemorrhage(Ostrum et al, 1993;Wertheimer et al, 2018), fat embolism(Allardyce et al, 1974;Blokhuis et al, 2017), knee stiffness(Morrison & Adams, 1949), and deep vein thrombosis of the lower extremity(Yang et al, 2022). The emergence of any complication poses a signi cant threat to individual's life.…”

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confidence: 99%

Segmental Femoral Fracture Malunion: Evidence and Prognostic Analysis of Medical Intervention in the 3rd Century BC

Haiyang,

Ruiqi,

Xiongfeng

et al. 2023

Preprint

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We examined the remains of an individual who was unearthed from the Tuchengzi site and was believed to be from the Warring States period in China. The remains exhibited segmental femoral fracture. We aimed to deduce the cause of fracture, medical interventions, healing process, and motion behavior after fracture healing using several techniques, including macroscopic observation, computed tomography, and finite element analysis. The findings suggested that the segmental nature of the fracture was likely caused by the same occupational activity. The morphology of the healed fracture indicated that the individual underwent medical intervention. The fracture healing process signified that the lower extremity underwent adequate fixation, while bone callus remodeling suggested the recovery of lower-extremity load-bearing capacity. The finite element analysis demonstrated that the fracture healed to such a degree that it could withstand the load of standing, but not the load of normal walking. We suggest that medical practitioners in the Warring States period possessed a good knowledge of thigh anatomy, enabling them to guide fracture reduction and fixation. Reasonable medical intervention facilitated fracture healing and load recovery. Although the individual was able to stand, walking necessitated compensatory movement or instrumental assistance due to femur deformity resulting from fracture healing.

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Increasing Our Knowledge of the Pathogenesis of Fat Embolism

Cited by 37 publications

References 0 publications

Enfoque Diagnostico del Síndrome de Embolia Grasa, Una Revisión Bibliográfica

Enfoque Diagnostico del Síndrome de Embolia Grasa, Una Revisión Bibliográfica

Segmental femoral fracture malunion: evidence and prognostic analysis of medical intervention in the third century BC

Segmental Femoral Fracture Malunion: Evidence and Prognostic Analysis of Medical Intervention in the 3rd Century BC

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