Increasing our understanding of rotavirus-induced central nervous system manifestations

Kim, Jon Soo

doi:10.3345/cep.2022.00395

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…6) While studies of enteric viral pathogens and their direct or indirect mechanisms involving the central nervous system have been reported, the underlying pathophysiology of CwG remains to be elucidated. 7) Na et al 8) analyzed the impact of changes in enteric viral infections on the clinical aspects of CwG before and after the COVID-19 pandemic. They analyzed data of CwG cases occurring at a single tertiary center from the past 6 years before and after the pandemic and identified 3 significant findings.…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

Impact of COVID-19 pandemic on clinical features of benign convulsions with mild gastroenteritis

Kim

2024

Clin Exp Pediatr

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Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

Impact of COVID-19 pandemic on clinical features of benign convulsions with mild gastroenteritis

Kim

2024

Clin Exp Pediatr

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“…Rotavirus infection is a leading cause of mortality and morbidity in infants and young children, and these infections are also linked to autoimmunity . While some individuals recover without complications, others develop manifestations affecting various organs, and viral dissemination may occur . Moreover, some infected children experience extraintestinal complications that influence specific organs or whole body systems.…”

Section: Introductionmentioning

confidence: 99%

“… 1 , 2 , 3 While some individuals recover without complications, others develop manifestations affecting various organs, and viral dissemination may occur. 4 , 5 , 6 , 7 , 8 Moreover, some infected children experience extraintestinal complications that influence specific organs or whole body systems. Several lines of evidence suggest that rotavirus infection can trigger autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

Rotavirus-Associated Hospitalization in Children With Subsequent Autoimmune Disease

Kim

Ryeong

et al. 2023

JAMA Netw Open

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ImportanceRotavirus infection is a common cause of gastroenteritis in children that can trigger autoimmune processes, but the nature of this interaction remains poorly understood.ObjectiveTo estimate the association of rotavirus infection with the risk of subsequent autoimmune disease.Design, Setting, and ParticipantsThis population-matched cohort study used data from children and adolescents (aged younger than 18 years) in South Korea (national registers from January 1, 2002, to December 31, 2017). The cohort consisted of 86 157 patients in the exposure group who had experienced rotavirus-associated hospitalization and the same number of matched patients in the unexposed group. Data analyses were from May 1, 2020, through October 20, 2022.ExposuresHospitalization for rotavirus infection.Main Outcomes and MeasuresThe main outcome was childhood autoimmune diseases during the study defined by diagnoses according to the National Health Insurance Database. Hazard ratios (HRs) with 95% CIs for autoimmune diseases were estimated using a Cox model, with multiple confounding factors controlled.ResultsThis cohort study consisted of 1 914 461 individuals born in South Korea from 2002 to 2005 who were potentially eligible. After exclusions, there were 86 517 individuals in the exposed group and 86 517 in the unexposed group after 1:1 incidence density sampling. The study included 49 072 (57.0%) male patients. The median (IQR) age at diagnosis of rotavirus-associated hospitalization was 1.5 (0.9-2.7) years, and the HR for autoimmune disease in the exposed group was 1.24 (95% CI, 1.19-1.28) for a mean (SD) follow-up time of 12.1 (3.2) years. The use of more stringent definitions for exposure and outcomes in a multivariable stratified analysis also indicated that rotavirus-associated hospitalization was associated with an increased risk of subsequent autoimmune disease (HR, 1.22 [95% CI, 1.16-1.28]). Sensitivity analysis showed that individuals with rotavirus-associated hospitalization was related to multiple autoimmune syndromes (2 or more: HR, 1. 51 [95% CI, 1. 31-1. 73]; 3 or more: HR, 1. 79 [95% CI, 1.18-2.72]) and that the number of rotavirus-associated hospitalization were associated with higher risks for autoimmune disease in a dose-dependent manner (single hospitalization event: HR, 1.20 [95% CI, 1.16-1.24]; multiple events HR, 1.60 [95% CI, 1.49-1.72]).Conclusions and RelevanceOur results indicate that rotavirus-associated hospitalization is significantly associated with subsequent autoimmune disease during childhood. Clinicians should be aware of the heightened susceptibility to autoimmune disease in individuals with prior rotavirus-associated hospitalization.

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Rotavirus Hospitalization in Early Childhood: Fine Motor Skills and Cognition at 6 Years Old in a Population-Based Cohort Study

Ha,

Kim,

Han

et al. 2024

The Journal of Infectious Diseases

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Rotavirus is linked to severe childhood gastroenteritis and neurological complications, but its impact on neurodevelopment remains uncertain. We examined data from 1,420,941 Korean children born between 2009 and 2011, using the Korean National Health Insurance System. At age 6, we assessed neurodevelopmental outcomes using the validated Korean Developmental Test, covering six major domains. Utilizing propensity score-based Inverse Probability Weighting to ensure covariates including considering covariates including sex, birth weight, changes in body weight from birth to 4–6 months of age, head circumference at 4–6 months of age, residence at birth, economic status, infant feeding types, and birth year. The main analysis that encompassed 5,451 children with rotavirus hospitalization and 310,874 unexposed individuals reveled heightened odds of suspected delays in fine motor skills and cognition among exposed children. Our results suggest an association between rotavirus-related hospitalization in infancy and suspected delays in fine motor function and cognition in 6-year-olds.

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Increasing our understanding of rotavirus-induced central nervous system manifestations

Cited by 3 publications

References 10 publications

Impact of COVID-19 pandemic on clinical features of benign convulsions with mild gastroenteritis

Impact of COVID-19 pandemic on clinical features of benign convulsions with mild gastroenteritis

Rotavirus-Associated Hospitalization in Children With Subsequent Autoimmune Disease

Rotavirus Hospitalization in Early Childhood: Fine Motor Skills and Cognition at 6 Years Old in a Population-Based Cohort Study

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