Increasing Prevalence and Intensity of Foodborne Clonorchiasis, Hengxian County, China, 1989–2011

Qian, Men-Bao; Chen, Ying-Dan; Yang, Yue; Lu, Ming-Fei; Jiang, Zhihua; Kang, Wenli; Wei, Si-Liang; Zhou, Changhai; Xu, Lei; Zhou, Xiao‐Nong

doi:10.3201/eid2011.131309

Cited by 20 publications

(21 citation statements)

References 8 publications

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“…In terms of gender, the positive rate in males was higher than that of females, and in terms of distribution among all age groups, the positive rate was higher in 50s and 60s. In the previous studies [19,24,25], males showed higher positive rate than females, showing the same results as this study. By age group, the results of previous studies which showed high positive rates in 40s and in 50s were considered to be similar to those of the 50s and 60s of this study.…”

Section: Nosupporting

confidence: 78%

“…Compared with the results of Lee et al's and Park et al's, the positive rate in this study shows a tendency to decrease. However, since 1989 in China, the rate of Clonorchis sinensis positive rate gradually increased to 46.5% in 2011 [19], showing a very high positive rate as compared with that of Korea. Despite the high economic growth, Korea and China have a dietary culture to enjoy freshwater fish, so Clonorchis sinensis infection is still regarded as a health problem which calls for a national strategy.…”

Section: Nomentioning

confidence: 99%

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Prevalence and Related Factors of Clonorchiasis among Five Major Riverside Residents in South Korea

Kim

June

Cho

et al. 2016

J Korean Acad Community Health Nurs

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Purpose: This study attempted to investigate the prevalence and related factors of Clonorchiasis among five major riverside residents in South Korea. Methods: This study is descriptive research, nationwide survey, and the subjects are 23,492 residents selected by convenience sampling. Data collection was conducted between March 1 and June 30, 2011, and stool collection and questionnaire survey were conducted by affiliated public health centers in 38 cities and Gun's. Results: The prevalence rates of Clonorchiasis in the five major riversides were as follows: the Guem River 15.2%; the Nakdong River 11.9%; the Seomjin River 10.9%; the Han River 5.7%; and the Yeongsan River 3.9%. The prevalence rates were shown to be significantly high among people who had highly frequent experiences of eating and cooking freshwater raw fish, were diagnosed with liver and/or biliary tract diseases, and drank less than once a month. Conclusion: These results suggest that it is necessary to improve awareness of Clonorchiasis and provide intensive public health education for the riverside residents. And the target groups should be set up by reflecting the characteristics of at-risk groups, and it is necessary to prepare customized strategies for prevention and management of Clonorchiasis.

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Section: Nosupporting

confidence: 78%

Section: Nomentioning

confidence: 99%

Prevalence and Related Factors of Clonorchiasis among Five Major Riverside Residents in South Korea

Kim

June

Cho

et al. 2016

J Korean Acad Community Health Nurs

View full text Add to dashboard Cite

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“…The people regularly consume raw fish even though the incidence of C . sinensis infection is high, and the infection rate has reached 53.6% (Qian et al 2014 ). In this investigation, C .…”

Section: Discussionmentioning

confidence: 99%

Clonorchis sinensis infection and co-infection with the hepatitis B virus are important factors associated with cholangiocarcinoma and hepatocellular carcinoma

et al. 2017

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To evaluate the contributions of Clonorchis sinensis and hepatitis B virus to the development of cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC), C. sinensis and hepatitis B virus infections in 20 clinical liver cancer cases from a C. sinensis- and hepatitis B virus-epidemic region were detected. Eight cases of ICC, 11 cases of HCC and one mixed ICC and HCC case were verified by CT, pathological section and (or) observations during surgery. The C. sinensis infection was detected by stool microscopy and ELISA, and the worms and eggs found during surgery and in pathological sections also allowed for diagnoses. Hepatitis B virus infections were detected by ELISA. In the 20 cases, 18 patients were diagnosed with C. sinensis infections. Eight of the 20 patients were infected with the hepatitis B virus, and seven were co-infected with C. sinensis. In the eight ICC patients, seven were diagnosed with C. sinensis infection, and two had mixed infections with the hepatitis B virus. In the 11 HCC patients, 10 were diagnosed with C. sinensis, four had mixed infections with the hepatitis B virus, and only one HCC patient presented a single infection by the hepatitis B virus. These clinical observations revealed that C. sinensis infection and C. sinensis co-infection with the hepatitis B virus are important factors in ICC and HCC.

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“…The sera from those infected with C. sinensis and control 1 were collected through a cross-sectional survey in Hengxian county, Guangxi Zhuang Autonomous Region, China, where C. sinensis infection is highly endemic [ 20 ]. One stool sample was collected from each participant.…”

Section: Methodsmentioning

confidence: 99%

Performance evaluation of existing immunoassays for Clonorchis sinensis infection in China

Qian

Yang

et al. 2018

Parasites Vectors

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BackgroundClonorchiasis ranks among the most important food-borne parasitic diseases in China. However, due to low compliance to traditional fecal examination techniques in the general population and medical personnel, immunodiagnosis is expected. This study evaluated, in parallel, the performance of four immunodiagnostic kits detecting clonorchiasis in China.ResultsA bank with 475 sera was established in this study. Except for the low performance of the kit detecting IgM, the other three kits detecting IgG showed sensitivities ranging from 81.51% (194/238) to 99.16% (236/238). Higher sensitivity was presented in heavy infection intensity [89.47% (68/76) to 100% (76/76)]. Among the four kits, the overall specificity varied from 73.42% (174/237) to 87.34% (207/237). It was observed that the specificity was lower in the sera of the participants living in clonorchiasis-endemic areas but without any parasite infection [67.5% (81/120) to 90% (108/120)], as compared to those from the non-endemic area [94% (47/50) to 98% (49/50)]. The cross-reaction rate varied from 14.93% (10/67) to 31.34% (21/67). Youden’s index was -0.022, 0.689, 0.726, and 0.802 for kits T1, T2, T3 and T4, respectively. Repeatability was high in all four kits.ConclusionsThree immunodiagnosis kits targeting IgG antibody had high performance on detecting chronic Clonorchis sinensis infection, but that detecting IgM antibody had not. The kits detecting IgG antibody also showed high sensitivity in heavy infection intensity. Research on immunological diagnosis of clonorchiasis is expected to be strengthened to improve the sensitivity in light infection and specificity.Electronic supplementary materialThe online version of this article (10.1186/s13071-018-2612-3) contains supplementary material, which is available to authorized users.

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Increasing Prevalence and Intensity of Foodborne Clonorchiasis, Hengxian County, China, 1989–2011

Cited by 20 publications

References 8 publications

Prevalence and Related Factors of Clonorchiasis among Five Major Riverside Residents in South Korea

Prevalence and Related Factors of Clonorchiasis among Five Major Riverside Residents in South Korea

Clonorchis sinensis infection and co-infection with the hepatitis B virus are important factors associated with cholangiocarcinoma and hepatocellular carcinoma

Performance evaluation of existing immunoassays for Clonorchis sinensis infection in China

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