Increasing prevalence of Escherichia coli and Klebsiella pneumoniae producing CTX-M-type extended-spectrum beta-lactamase, carbapenemase, and NDM-1 in patients from a rural community with community acquired infections: A 3-year study

Devi, Leimapokpam Sumitra; Broor, Shobha; Rautela, Rajendra Singh; Grover, Shyam Sunder; Chakravarti, Anita; Chattopadhya, Debasish

doi:10.4103/ijabmr.ijabmr_360_19

Cited by 19 publications

(1 citation statement)

References 28 publications

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“…Resistance to carbapenems is attributable to one or more carbapenemase genes ( bla KPC , bla NDM , bla VIM , bla OXA−48 , and bla IMP−Like ), whose expression usually leads to carbapenem resistance [ 12 ]. However, since the first carbapenem-resistant strain of K. pneumoniae (KPC) was isolated and characterized in 1996 by Yigit et al, carbapenem-resistant strains have increased rapidly and have received considerable public interest due to the scarcity of antibiotic treatment choices [ 13 , 14 ]. The limited therapy choices resulting from the inefficacy of novel beta-lactam/beta-lactamase inhibitor combos, such as ceftazidime-avibactam and meropenem/vaborbactam against NDM-producing pathogens (New Delhi metallo beta-lactamase) constituted an additional barrier [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Susceptibility Profiles of Klebsiella pneumoniae Strains Collected from Clinical Samples in a Hospital in Southern Italy

Santella,

Boccella,

Folliero

et al. 2024

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Infections caused by antibiotic-resistant bacteria represent a serious threat to global public health. Recently, due to its increased resistance to carbapenems and β-lactams, Klebsiella pneumoniae has become one of the main causes of septicemia, pneumonia, and urinary tract infections. It is crucial to take immediate action and implement effective measures to prevent further spread of this issue. This study aims to report the prevalence and antibiotic resistance rates of K. pneumoniae strains isolated from clinical specimens from 2015 to 2020 at the University Hospital of Salerno, Italy. More than 3,800 isolates were collected from urine cultures, blood cultures, respiratory samples, and others. K. pneumoniae isolates showed broad resistance to penicillin and cephalosporins, and increased susceptibility to fosfomycin and gentamicin. Extended spectrum beta-lactamase (ESBL) isolates accounted for 20–22%. A high percentage of strains tested were resistant to carbapenems, with an average of 40% to meropenem and 44% to ertapenem. The production of ESBLs and resistance to carbapenems is one of the major public health problems. Constant monitoring of drug-resistant isolates is crucial for developing practical approaches in implementing antimicrobial therapy and reducing the spread of K. pneumoniae in nosocomial environments.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Susceptibility Profiles of Klebsiella pneumoniae Strains Collected from Clinical Samples in a Hospital in Southern Italy

Santella,

Boccella,

Folliero

et al. 2024

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Multiresistant Enterobacteriaceae in yellow‐legged gull chicks in their first weeks of life

Vittecoq

Brazier

Elguero

et al. 2022

Ecology and Evolution

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Wild animal species living in anthropogenic areas are commonly carriers of antimicrobial-resistant bacteria (AMRB), but their role in the epidemiology of these bacteria is unclear. Several studies on AMRB in wildlife have been cross-sectional in design and sampled individual animals at only one point in time. To further understand the role of wildlife in maintaining and potentially transmitting these bacteria to humans and livestock, longitudinal studies are needed in which samples are collected from individual animals over multiple time periods. In Europe, free-ranging yellowlegged gulls (Larus michahellis) commonly live in industrialized areas, forage in landfills, and have been found to carry AMRB in their feces. Using bacterial metagenomics and antimicrobial resistance characterization, we investigated the spatial and temporal patterns of AMRB in a nesting colony of yellow-legged gulls from an industrialized area in southern France. We collected 54 cloacal swabs from 31 yellow-legged gull chicks in 20 nests on three dates in 2016. We found that AMRB in chicks increased over time and was not spatially structured within the gull colony. This study highlights the complex occurrence of AMRB in a free-ranging wildlife species and contributes to our understanding of the public health risks and implications associated with ARMBcarrying gulls living in anthropogenic areas.

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Nanocomposites: silver nanoparticles and bacteriocins obtained from lactic acid bacteria against multidrug-resistant Escherichia coli and Staphylococcus aureus

Pineda,

Sánchez,

Caycedo

et al. 2024

World J Microbiol Biotechnol

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Increasing prevalence of Escherichia coli and Klebsiella pneumoniae producing CTX-M-type extended-spectrum beta-lactamase, carbapenemase, and NDM-1 in patients from a rural community with community acquired infections: A 3-year study

Cited by 19 publications

References 28 publications

Antimicrobial Susceptibility Profiles of Klebsiella pneumoniae Strains Collected from Clinical Samples in a Hospital in Southern Italy

Antimicrobial Susceptibility Profiles of Klebsiella pneumoniae Strains Collected from Clinical Samples in a Hospital in Southern Italy

Multiresistant Enterobacteriaceae in yellow‐legged gull chicks in their first weeks of life

Nanocomposites: silver nanoparticles and bacteriocins obtained from lactic acid bacteria against multidrug-resistant Escherichia coli and Staphylococcus aureus

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