Increasing prevalence of gestational diabetes mellitus in Chinese women from 1999 to 2008

Zhang, F.; Dong, Ling; Zhang, C.P.; Li, B.; Wen, Jinkun; Gao, Wen; Sun, Shurong; Lv, F.; Tian, Hui; Tuomilehto, Jaakko; Qi, Lü; Zhang, C. L.; Yu, Zhijie; Yang, Xilin; Hu, Gang

doi:10.1111/j.1464-5491.2010.03205.x

Cited by 173 publications

(172 citation statements)

References 25 publications

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“…Given the rise in the incidence of GDM over the past decade in China2, research to identify modifiable determinants of glucose intolerance has become a public health priority.…”

Section: Introductionmentioning

confidence: 99%

Changes in serum adipocyte fatty acid‐binding protein in women with gestational diabetes mellitus and normal pregnant women during mid‐ and late pregnancy

Zhang

Lü

et al. 2016

J of Diabetes Invest

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Aims/IntroductionTo observe the longitudinal changes in serum adipocyte fatty acid‐binding protein (AFABP), carbohydrate, and lipid metabolism parameters in women with and without gestational diabetes mellitus (GDM) during mid‐ and late pregnancy periods, as well as to identify whether there is any association between AFABP and development of GDM.Materials and MethodsA total of 40 GDM and 240 normal glucose tolerance participants were enrolled at 24–28 weeks and completed the study. The clinical features, serum AFABP, other adipocytokines (leptin, adiponectin, retinol‐binding protein 4), homeostasis model assessment of insulin resistance, and lipid profiles were measured in the second and third trimesters of pregnancy.ResultsCompared with the normal glucose tolerance group, the GDM group showed greater levels of AFABP, leptin and retinol‐binding protein 4; and a decreased level of adiponectin (P < 0.05 or P < 0.01) during mid‐ and late pregnancy periods. Prepregnancy body mass index was the independent factor impacting serum AFABP levels in the second (β = 0.567, P = 0.004) and third trimesters (β = 0.619, P = 0.001). Furthermore, GDM was independently associated with AFABP concentrations in multiple regression analysis in the second and third trimester (all P < 0.01). Serum AFABP, leptin and retinol‐binding protein 4 are risk factors for GDM; adiponectin is a protective factor for GDM (P < 0.05 or P < 0.01).ConclusionsThe GDM group had a higher level of AFABP during mid‐ and late stages of pregnancy; prepregnancy body mass index and GDM were the independent factors with respect to serum AFABP. AFABP might be closely related to obesity, insulin resistance and leptin resistance in pregnancy, and is a major risk factor for GDM.

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“…Given the rise in the incidence of GDM over the past decade in China2, research to identify modifiable determinants of glucose intolerance has become a public health priority.…”

Section: Introductionmentioning

confidence: 99%

Changes in serum adipocyte fatty acid‐binding protein in women with gestational diabetes mellitus and normal pregnant women during mid‐ and late pregnancy

Zhang

Lü

et al. 2016

J of Diabetes Invest

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“…Coinciding with the rapid economic development, the Chinese population has been experiencing a rapid lifestyle change, tending toward a more sedentary and high-energy/ high-fat diet (27). These changes have resulted in marked increases of both overweight (from 20.0% in 1992 to 29.9% in 2002 in Chinese aged 18 years) (28,29) and GDM (from 2.4% in 1999 to 8.2% in 2012 in urban Chinese women aged 20 years) (30). As overweight and GDM are both important risk factors for diabetes, the control of overweight among women with prior GDM could largely reduce and delay the development of diabetes.…”

Section: Original Article Obesity Epidemiology/geneticsmentioning

confidence: 99%

“…All pregnant women at 26-30 gestational weeks participated in a 1-h 50-g glucose screening test (GCT). Women who had a glucose reading 7.8 mmol/l were invited to undergo a 2-h 75-g oral glucose tolerance test (OGTT) at the Tianjin Women and Children's Health Center (7). GDM is defined using the using the World Health Organization (WHO)'s criteria (8).…”

Section: Tianjin Gdm Screening Projectmentioning

confidence: 99%

Prepregnancy body mass index and weight change on postpartum diabetes risk among gestational diabetes women

Liu

Zhang

et al. 2014

Obesity

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Objective: To evaluate the effects of prepregnancy BMI and weight change from prepregnancy to postpartum on postpartum type 2 diabetes (T2D) risk among women with gestational diabetes (GDM). Methods: A retrospective cohort study in 1,263 GDM women at 1-5 years after delivery was performed. Cox proportional hazards regression models were used to evaluate the association of prepregnancy BMI and weight change with T2D and prediabetes risks. Results: The multivariable-adjusted hazard ratios based on different levels of prepregnancy BMI (<23, 23-24.9, 25-29.9, and 30 kg/m 2 ) were 1.00, 1.77, 2.35, and 6.54 (P trend < 0.001) for incident T2D, and 1.00, 1.46, 1.87, and 1.79 (P trend < 0.001) for incident prediabetes, respectively. Compared with women with stable weight (63 kg), those with weight gain 7 kg had an 86% and a 32% increased risk of diabetes and prediabetes, and those with weight loss 3 kg had a 45% decreased risk of prediabetes. The positive associations of prepregnancy BMI with incident diabetes and prediabetes risk were persistent in women with different levels of weight change (<3 kg and 3 kg). Conclusion: Prepregnancy obesity and excessive weight gain from prepregnancy to postpartum increase postpartum diabetes and prediabetes risks among GDM women.

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“…2 In the 1990s, the prevalence of GDM in Hong Kong was approximately 14.2%. 3 Studies in China and the United States show that the incidence of GDM has been increasing in recent years, 4,5 thus increasing the risk of complications for both mother and child during pregnancy, childbirth, and beyond. 6 Notably, it is reported that high first-trimester glucose levels are associated with an increased risk of a diagnosis of GDM later in pregnancy and adverse pregnancy outcome.…”

Section: Introductionmentioning

confidence: 99%

Association between pregnancy-associated plasma protein-A levels in the first trimester and gestational diabetes mellitus in Chinese women

Wong

et al. 2015

Hong Kong Med J

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Introduction:Several studies have shown that women with pre-existing diabetes mellitus have significantly lower pregnancy-associated plasma protein-A levels than those without. This study aimed to evaluate whether first-trimester pregnancyassociated plasma protein-A multiple of median is associated with gestational diabetes mellitus in Chinese pregnant women. Methods:This prospectively collected case series was conducted in a regional hospital in Hong Kong. All consecutive Chinese women with a singleton pregnancy who attended the hospital for their first antenatal visit (before 14 weeks' gestation) from April to July 2014 were included. Pregnancyassociated plasma protein-A multiple of median was compared between the gestational diabetic (especially for early-onset gestational diabetes) and non-diabetic groups. The correlation between pregnancy-associated plasma protein-A level and glycosylated haemoglobin level in women with gestational diabetes was also examined. Results:Of the 520 women recruited, gestational diabetes was diagnosed in 169 (32.5%). Among them, 43 (25.4%) had an early diagnosis, and 167 (98.8%) with the disease were managed by diet alone. The gestational diabetic group did not differ significantly to the non-diabetic group in pregnancyassociated plasma protein-A (0.97 vs 0.99, P=0.40) or free β-human chorionic gonadotrophin multiple of median (1.05 vs 1.02, P=0.29). Compared with the non-gestational diabetic group, women with early diagnosis of gestational diabetes had a non- Association between pregnancy-associated plasma protein-A levels in the first trimester and gestational diabetes mellitus in Chinese womenNew knowledge added by this study • This is the first study to assess the association of first-trimester pregnancy-associated plasma protein-A multiple of median (PAPP-A MoM) with gestational diabetes mellitus (GDM) in a Chinese population. PAPP-A MoM was not predictive of development of non-insulin-dependent GDM in Chinese women.• There was no correlation between PAPP-A MoM and glycosylated haemoglobin level in Chinese women with GDM. PAPP-A levels were not useful to predict and identify poor glycaemic control in women with GDM.• There was a high prevalence of GDM (32.5%) in the Chinese population. Implications for clinical practice or policy • PAPP-A and β-human chorionic gonadotrophin do not seem to be predictive of non-insulin-dependent GDM.Other predictive model that comprises the maternal and clinical risk factors in Chinese women is warranted to identify women at risk of GDM.• Further studies that employ the new diagnostic criteria for GDM are warranted to examine the potential of first-trimester biochemical markers to predict GDM as well as their influence on the prevalence of GDM in the Chinese population.

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Increasing prevalence of gestational diabetes mellitus in Chinese women from 1999 to 2008

Abstract: The prevalence of gestational diabetes mellitus has markedly been increasing in a universally screened urban Chinese female population and has become an important public health problem in China.

Cited by 173 publications

References 25 publications

Changes in serum adipocyte fatty acid‐binding protein in women with gestational diabetes mellitus and normal pregnant women during mid‐ and late pregnancy

Changes in serum adipocyte fatty acid‐binding protein in women with gestational diabetes mellitus and normal pregnant women during mid‐ and late pregnancy

Prepregnancy body mass index and weight change on postpartum diabetes risk among gestational diabetes women

Association between pregnancy-associated plasma protein-A levels in the first trimester and gestational diabetes mellitus in Chinese women

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