A heterogeneous material image enhancement method based on multi-exposure image fusion is proposed to address the problem of obtaining high-quality images from the single imaging of chips containing two extremely different reflectivity materials. First, a multi-exposure image fusion algorithm based on window segmentation and Laplacian pyramid fusion is proposed. Then, orthogonal experiments are used to optimize the parameters of the imaging system. Next, a method based on information entropy and average gray intensity is utilized to calculate the imaging exposure times of two heterogeneous materials, and two exposure time ranges are obtained that are appropriate for regions with high and low reflectivity. Finally, the subjective and objective experimental evaluations are conducted after the multi-exposure image set has been established. The results show that the fused image has a good visual effect, the information entropy is 6.29, and the average gray intensity is 131.56. In addition, time consumption is reduced by an average of 20.3% compared to the Laplace pyramid strategy. The heterogeneous material enhancement method based on multi-exposure image fusion proposed in this paper is effective and deserving of further research and application.