Increasing Rates of Infective Endocarditis in Patients with Inflammatory Bowel Disease

Shah-Khan, Sardar M.; Alqahtani, Fahad; Kupec, Justin

doi:10.7759/cureus.6919

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Moreover, the potential benefits of prophylaxis need to be outweighed against the risks of resistance, anaphylaxis and Clostridioides difficile infection. 12 …”

Section: Discussionmentioning

confidence: 99%

Infective Endocarditis After Endoscopic Stricture Dilation in Crohn's Disease

Gonçalves,

Barbeiro,

Leal

et al. 2024

ACG Case Rep J

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Stricture formation is common in Crohn's disease, and endoscopic intervention plays an increasingly important role in managing these strictures. A 61-year-old man with biological aortic prosthesis and a 30-year history of ileocolonic stricturing Crohn's disease, managed with azathioprine and infliximab, presented with marked occlusive symptoms. Colonoscopy revealed a descending colon stricture, prompting endoscopic balloon dilation. At the time of the procedure, no prophylactic antibiotic was given. Subsequently, he developed Streptococcus gallolyticus endocarditis, necessitating aortic valve replacement. The authors present a case of late Streptococcus gallolyticus endocarditis associated with endoscopic balloon dilation of a Crohn-related colonic stricture.

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“…Moreover, the potential benefits of prophylaxis need to be outweighed against the risks of resistance, anaphylaxis and Clostridioides difficile infection. 12 …”

Section: Discussionmentioning

confidence: 99%

Infective Endocarditis After Endoscopic Stricture Dilation in Crohn's Disease

Gonçalves,

Barbeiro,

Leal

et al. 2024

ACG Case Rep J

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“…Recently Lauri G reported the use of ustekinumab for induction and maintenance therapy in type 2 AIP-UC patients with good results (120). Ustekinumab is a monoclonal antibody targeting the p40 subunit of IL 12 and IL 23 (IL12/23p40), IL-23 promotes differentiation of Th cells into Th17 and secretes inflammatory cytokines such as IL-17 and IL-22, whereas IL-12 induces Th1 and produces other cytokines such as interferon-gamma and TNF (121), thus ustekinumab could play an important role in the treatment of type 2 AIP-UC. Neutrophil infiltration is a typical feature of type 2 AIP and UC, and Chiabrando F reported a case report on the use of colchicine, which targets neutrophils, in the treatment of type 2 AIP (122), but colchicine needs to be further explored in the treatment of UC.…”

Section: Treatment and Challenges Of Type 2 Aip-ucmentioning

confidence: 99%

Type 2 autoimmune pancreatitis associated with ulcerative colitis

Nan,

Wang

2023

Front. Immunol.

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Ulcerative colitis (UC) is a chronic idiopathic inflammatory disease mainly affecting the rectum and colon and causing diarrhoea and mucopurulent stools. UC can present with extraintestinal manifestations in various organs and systems and can be associated with various comorbidities. Autoimmune pancreatitis (AIP) is a specific type of pancreatitis associated with autoimmune abnormalities and is divided into two clinical types: type 1 (lymphoplasmacytic sclerosing pancreatitis) and type 2 (idiopathic ductocentric pancreatitis). The current study shows an association between type 2 AIP and UC, which may be related to genetic susceptibility, inflammatory factors, and immune response. The most common manifestation of AIP in patients with type 2 AIP–UC is abdominal pain with elevated pancreatic enzymes, whereas the presentation of UC in type 2 AIP–UC is more severe, with an increased risk of UC-related surgery. This review focuses on diagnosis, prevalence, pathogenesis, impact, and treatment to better understand type 2 AIP–UC, explore the molecular mechanisms of this condition, and encourage further research into the management of type 2 AIP–UC.

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“…dialysis, injection drug use, surgical procedures) and in most cases requires a defective heart valve for platelet formation as a growth medium for bacteria [ 1 ]. Bacteria may come from the oral cavity, gut, or skin [ 2 , 4 , 5 ]. Previous studies by our group have focused on the incidence, nature, duration, and magnitude of bacteremia originating from the oral cavity [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Oral microbiomes of patients with infective endocarditis (IE): a comparative pilot study of IE patients, patients at risk for IE and healthy controls

Mougeot

Beckman

Paster³

et al. 2022

Journal of Oral Microbiology

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Background Infective endocarditis (IE) is an uncommon disease with high morbidity and mortality rates, which often develops from oral bacterial species entering circulation. Objective We compared oral microbiome profiles of three groups: IE patients (N 9 patients; n = 27 samples), disease controls at risk for IE (N = 28; n = 84), and healthy controls (N = 37; n = 111). Bacterial species in IE patients’ blood cultures were identified for comparison with matched oral samples. Design Oral microbiome profiles were obtained from buccal mucosa, saliva, and tongue samples for all three groups and from sub- and supra-gingival plaque samples of the IE group (N = 9; n = 16) and disease controls (N = 28; n = 54). Alpha - and beta -diversities were determined based on relative abundance data. Discriminative species were identified by LEfSe, post hoc Mann-Whitney, and ROC analyses. Identity of the bacterial species in IE patients’ blood cultures was confirmed by 16S-rRNA gene Sanger sequencing. Results Alpha - and beta -diversities differed between groups. Discriminative IE-associated species were identified, e.g. Haemophilus parainfluenzae and Streptococcus sanguinis . Two blood isolates were Staphylococcus aureus , also identified in one matched saliva sample. Streptococcus mutans was present in one patient’s plaque samples and blood culture. Conclusions Oral microbiomes of IE, non-IE disease controls, and healthy controls differed significantly. A better understanding of IE-related bacterial-host interactions is warranted.

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Increasing Rates of Infective Endocarditis in Patients with Inflammatory Bowel Disease

Cited by 5 publications

References 23 publications

Infective Endocarditis After Endoscopic Stricture Dilation in Crohn's Disease

Infective Endocarditis After Endoscopic Stricture Dilation in Crohn's Disease

Type 2 autoimmune pancreatitis associated with ulcerative colitis

Oral microbiomes of patients with infective endocarditis (IE): a comparative pilot study of IE patients, patients at risk for IE and healthy controls

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