Introduction: The substitute therapies of the renal function constitute a support of life, nevertheless they are temporary treatments until realizing renal transplantation (TR), meanwhile the complications are present the deterioration of the quality and reduction of the life expectancy. The TR rehabilitates, gives the possibility of a normal life, family, social and labor reintegration. The reference to TR day by day becomes more frequent and knowing the behavior will allow to implement improvement strategies. Material and methods: Retrospective and cross-sectional study conducted from 2014 to 2019, includes data on references to TR generated by the general and regional hospitals of the IMSS of subjects up to 65 years of age. Reference location is identified, gender, age, cause of chronic renal failure (CRF), modality of replacement therapy. Results: 19,979 patients were referred, 12,386 were male (62%) and 7,593 female (38%), aged 1 to 65 years, the group of 20 to 29 years was the most prevalent (30%). The highest number of references received peritoneal dialysis 9,166 (46%), hemodialysis 8,981 (45%), and 1,832 (9%) pre-dialysis. The reference increased 8.7% annual average in all the dialysis modalities. Conclusions: The reference presents a continuous increase and pre-dialysis patients each year are referred in greater numbers. The demand for renal transplantation exceeds the needs of the institution and offers a large area of opportunity to favor a greater number of patients.