Increasing the aqueous solubility of N-acyl-substituted amino acid esters as inhibitors of viral replication in vitro using iron(II) ions

Garaev, Timur M.; Yudin, Ilya I.; Breslav, Natalya V.; Grebennikova, Tatyana V.; Avdeeva, Varvara V.; Goeva, Lyudmila V.; Golubev, Aleksey V.; Kubasov, Alexey S.; Nikiforova, Svetlana E.; Malinina, Elena A.

doi:10.1016/j.tet.2023.133785

Tetrahedron

2024

DOI: 10.1016/j.tet.2023.133785

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Increasing the aqueous solubility of N-acyl-substituted amino acid esters as inhibitors of viral replication in vitro using iron(II) ions

Timur M. Garaev,

Ilya I. Yudin,

Natalya V. Breslav

et al.

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2024

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Cited by 2 publications

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Increasing the Water Solubility of N-Acyl-Substituted Amino Acid Esters as Inhibitors of the Replication of Modern Influenza A Virus Strains In Vitro by Zinc(II) Complexation

Garaev,

Yudin,

Breslav

et al. 2024

Russ. J. Inorg. Chem.

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Increasing the Water Solubility of N-Acyl-Substituted Amino Acid Esters as Inhibitors of the Replication of Modern Influenza A Virus Strains In Vitro by Zinc(II) Complexation

Garaev,

Yudin,

Breslav

et al. 2024

Russ. J. Inorg. Chem.

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Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains <i>in vitro</i> due to zinc(II) complexation

Garaev,

Yudin,

Breslav

et al. 2024

Žurnal neorganičeskoj himii

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This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.

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Increasing the aqueous solubility of N-acyl-substituted amino acid esters as inhibitors of viral replication in vitro using iron(II) ions

Cited by 2 publications

References 32 publications

Increasing the Water Solubility of N-Acyl-Substituted Amino Acid Esters as Inhibitors of the Replication of Modern Influenza A Virus Strains In Vitro by Zinc(II) Complexation

Increasing the Water Solubility of N-Acyl-Substituted Amino Acid Esters as Inhibitors of the Replication of Modern Influenza A Virus Strains In Vitro by Zinc(II) Complexation

Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains <i>in vitro</i> due to zinc(II) complexation

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