Along with the rapid development of infrastructure and the high demand for concrete, concrete is required to continue to grow even better. Reactive Powder Concrete (RPC) is a high-quality concrete innovation. RPC is a concrete innovation that replaces coarse aggregate with fine aggregate, thereby increasing its homogeneity, making concrete have high compressive strength, durability, and impermeability. Indonesia is an archipelagic country united by a vast ocean. This causes buildings in coastal areas and seas to be vulnerable to attack by chlorides which are harmful to concrete. This study aims to determine the effect of using 0%, 15%, 20%, 25%, 30%, 35%, and 40% quartz sand by weight of fine aggregate against chloride uptake in RPC. The method used is experimental. The test object used was cylindrical concrete with a diameter of 7.5 cm and a height of 15 cm. The chloride absorption test was carried out by immersing the concrete in 4% chloride solution for 10+0.5 minutes and 24 hours then weighing it in dry SSD state and comparing it to the dry oven. The lowest value occurred when the quartz sand content was 30% with an absorption value of 0.68% for 10+0.5 minute immersion and 1.58% for 24 hour immersion.