Increasing the donor pool using en bloc pediatric kidneys for transplant

Abstract

Overall graft survival was similar in both groups, vascular complications were the main cause of graft loss in EBPKT, and the EBPKT showed excellent long-term graft function and a low incidence of acute rejection.

Untitled

“…11 A limited number of relatively small series of pediatric donor kidneys report a significantly better long-term outcome for en bloc transplanted pediatric kidneys once they survive the early postoperative course with 5-year survival rates of 76% to 82%. 14,15 Despite encouraging results, there are a few studies that have evaluated the outcomes of kidneys from young pediatric donors. While the results of the en bloc transplants using kidneys from donors between 2 and 5 years of age were similar to solitary transplants from standard criteria donors, worse outcomes have been reported when using similar techniques with kidneys from donors younger than 2 years of age.…”

“…While the results of the en bloc transplants using kidneys from donors between 2 and 5 years of age were similar to solitary transplants from standard criteria donors, worse outcomes have been reported when using similar techniques with kidneys from donors younger than 2 years of age. 15 In the United Kingdom, kidneys from pediatric donors up to 5 years old, or up to 15 kg in weight, are offered en bloc for transplant, usually to an adult recipient. In most instances, allocation of these kidneys to recipient is left to the center's discretion.…”

Superiority of Pediatric En Bloc Renal Allografts Over Living Donor Kidneys: A Long-term Functional Study

“…Studies have shown comparable long-term graft survival between en bloc kidneys and adult cadaver donor kidneys (16 -18). Serial annual creatinine clearances were significantly better in en bloc kidneys compared to adult cadaver kidneys in the five-year follow-up in one study (18).…”

Expanding the Donor Kidney Pool: Utility of Renal Allografts Procured in a Setting of Uncontrolled Cardiac Death

“…Several strategies have been employed to reduce this ever-widening gap, which include living donor kidney transplantation, utilizing extended criteria donor kidneys, en-bloc kidneys from pediatric donors and hepatitis-positive donors (1)(2)(3). More recently, kidneys from donation after cardiac death (DCD) donors have been gaining acceptance.…”