Increasing the Extensional Viscosity of Silicone Oil Reduces the Tendency for Emulsification

Williams, Rachel; Day, M. H.; Garvey, Michael J.; English, Robert J.; Wong, David

doi:10.1097/iae.0b013e3181babe0c

Cited by 60 publications

(62 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Oil emulsification is considered to occur due to long-chain breakage as a result of shear forces generated by eye movement; the molecular design of Siluron Xtra ® enables an increase in shear force to concurrently increase the extensional viscosity enabling a relative resistance to emulsification. This has been demonstrated in in vitro experiments [6][7][8] . The dynamic extensional viscosity also enables the use of this agent in smaller-gauge surgery (23 G, 25 G) due to the alignment of the molecules in a relative chain, both during the initial retinal detachment repair procedure as well as during tamponade removal; this contrasts with other high-viscosity agents previously available [9] .…”

mentioning

confidence: 76%

Polydimethyl Siloxane as an Internal Tamponade for Vitreoretinal Surgery

Hussain

Myneni²,

Stappler³

et al. 2017

Ophthalmologica

Self Cite

View full text Add to dashboard Cite

Purpose: To report the efficacy and safety of polydimethyl siloxane (Siluron Xtra®) as an internal tamponade. Design: Audit and adverse event screening of procedures (March 2014-2015). Methods: Patients who had undergone vitreoretinal procedures with Siluron Xtra® tamponade were retrospectively analysed with respect to anatomical outcome, visual outcomes, and perioperative complications, in particular intraocular pressure. Inclusion Criteria: all patients who had undergone Siluron Xtra® tamponade. Exclusion Criteria: No cases were excluded; however, there were no paediatric or pregnant patients within this cohort. All vitreoretinal cases were included, including retinal detachments, but also trauma, endophthalmitis, and intraocular foreign bodies. Results: Twenty-eight patients had polydimethyl siloxane as an intraocular tamponade; 24 retinal detachments (83% complicated by proliferative vitreoretinopathy ≥grade C), 12 had previous failed surgery, and 4 had procedures for intraocular lymphoma, endophthalmitis, or trauma. Follow-up was 14-20 months, and mean duration of tamponade was 6.8 months (3-12 months). Anatomical success was 79% after polydimethyl siloxane injection, 58% 3 months following removal (14/24), 5 remain with long-term tamponade, and 5 with redetachment under tamponade required further intervention. Five required topical anti-glaucomatous agents, and 1 following trauma required glaucoma surgery. Cataract developed in 3/6 phakic patients, and visible emulsification occurred in a single patient. Conclusion: Polydimethyl siloxane seems to be an acceptable alternative tamponade agent for the management of complex retinal detachments with comparable anatomical success and comparable rates of raised intraocular pressure to other low-viscosity silicone oil agents, but more importantly, with a lower rate of emulsified oil-related complications, which is important particularly for cases requiring long-term tamponade.

show abstract

mentioning

confidence: 76%

Polydimethyl Siloxane as an Internal Tamponade for Vitreoretinal Surgery

Hussain

Myneni²,

Stappler³

et al. 2017

Ophthalmologica

Self Cite

View full text Add to dashboard Cite

show abstract

“…The authors suggest adding 5-10 % high-molecular-weight (HMW) SO (423 kDa) to 1,000 cSt SO. The resulting SO has the same chemical properties of those used in clinical practices but is more resistant to emulsifi cation and is relatively easy to inject and remove [ 25 ].…”

Section: Viscositymentioning

confidence: 94%

“…This may be due to higher fl uid fl ow through smaller infusion lines. In order to optimize the cutting and the speed of the vitrectomy through small-gauge system, we need to use a higher vacuum set (450-650 mmHg) and higher bottle infusion (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). Such settings generate high turbulence inside the PFCL if the level of PFCL fl uid is close to the fl uid infusion line.…”

Section: Risk Factorsmentioning

confidence: 98%

Complications of Tamponades in Vitreoretinal Surgery

Romano

Vallejo-Garcia

Heimann

2015

Management of Complicated Vitreoretinal Diseases

View full text Add to dashboard Cite

“…To overcome this, current standard clinical silicone oils have a shear viscosity of 5000 mPa s, however, the higher the viscosity the more difficult the oil is to inject into the eye and remove after 3-6 months. Recently a new silicone oil has been produced that has been developed to have an increased resistance to emulsification [92][93][94] whilst maintaining the ease of injection [95]. The increase in the emulsification resistance was achieved by including a viscoelastic element to the oil by adding a low concentration of a very high molecular weight polymer to the oil.…”

Section: Vitreousmentioning

confidence: 99%

Biomaterials for ocular reconstruction

2014

View full text Add to dashboard Cite

Synthetic materials have played a significant role in ophthalmic applications to improve vision for many years. This has been in four main areas in ophthalmology: ocular surface reconstruction, lens replacement, vitreous replacement and structural support and cell transplantation in the retina. Corneal replacement therapies have been developed using both synthetic acrylic-based materials and more recently naturally derived materials such as amniotic membrane.

show abstract

Increasing the Extensional Viscosity of Silicone Oil Reduces the Tendency for Emulsification

Abstract: The addition of low concentrations of very-high-molecular-weight polymers of the same chemistry as the bulk oil has the potential to increase the emulsification resistance of the tamponade agents while maintaining ease of injection and removal.

Cited by 60 publications

References 15 publications

Polydimethyl Siloxane as an Internal Tamponade for Vitreoretinal Surgery

Polydimethyl Siloxane as an Internal Tamponade for Vitreoretinal Surgery

Complications of Tamponades in Vitreoretinal Surgery

Biomaterials for ocular reconstruction

Contact Info

Product

Resources

About