Increasing the production of the bioactive compounds in medicinal mushrooms: an omics perspective

Arshadi, Nooshin; Nouri, Hoda; Moghimi, Hamid

doi:10.1186/s12934-022-02013-x

Cited by 19 publications

(8 citation statements)

References 253 publications

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“…Full disclosure of the criteria whereby certain compounds are extracted and prepared is warranted. In this respect, metabolomic engineering and technologies may be very useful in the optimization and standardization of preparations [ 155 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer

Gariboldi,

Marras,

Ferrario

et al. 2023

IJMS

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Edible/medicinal mushrooms have been traditionally used in Asian countries either in the cuisine or as dietary supplements and nutraceuticals. In recent decades, they have aroused increasing attention in Europe as well, due to their health and nutritional benefits. In particular, among the different pharmacological activities reported (antibacterial, anti-inflammatory, antioxidative, antiviral, immunomodulating, antidiabetic, etc.), edible/medicinal mushrooms have been shown to exert in vitro and in vivo anticancer effects on several kinds of tumors, including breast cancer. In this article, we reviewed mushrooms showing antineoplastic activity again breast cancer cells, especially focusing on the possible bioactive compounds involved and their mechanisms of action. In particular, the following mushrooms have been considered: Agaricus bisporus, Antrodia cinnamomea, Cordyceps sinensis, Cordyceps militaris, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, Lentinula edodes, and Pleurotus ostreatus. We also report insights into the relationship between dietary consumption of edible mushrooms and breast cancer risk, and the results of clinical studies and meta-analyses focusing on the effects of fungal extracts on breast cancer patients.

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Section: Discussionmentioning

confidence: 99%

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer

Gariboldi,

Marras,

Ferrario

et al. 2023

IJMS

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“…Functional regions of genome, like regulatory sequences containing non-coding DNA, are commonly considered as part of junk DNA considering that their apparent functionality may not be directly evident (Morin et al 2012. Since genomic data make Genomics research has many applications and is a valuable tool for investigating edible fungi (Arshadi et al 2023). A general overview of several applications and frequently used methods in genomics research, detailing their distinct approaches, advantages, and limitations are summarized in Table 4 and illustrated in Figure 3.…”

Section: Ip2 Ip3mentioning

confidence: 99%

Complete mitochondrial genomes of edible mushrooms: features, evolution, and phylogeny

Zeb,

Aziz,

Azizullah

et al. 2024

Physiologia Plantarum

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Edible mushrooms are an important food source with high nutritional and medicinal value. They are a useful source for studying phylogenetic evolution and species divergence. The exploration of the evolutionary relationships among these species conventionally involves analyzing sequence variations within their complete mitochondrial genomes, which range from 31,854 bp (Cordyceps militaris) to 197,486 bp (Grifolia frondosa). The study of the complete mitochondrial genomes of edible mushrooms has emerged as a critical field of research, providing important insights into fungal genetic makeup, evolution, and phylogenetic relationships. This review explores the mitochondrial genome structures of various edible mushroom species, highlighting their unique features and evolutionary adaptations. By analyzing these genomes, robust phylogenetic frameworks are constructed to elucidate mushrooms lineage relationships. Furthermore, the exploration of different variations of mitochondrial DNA presents novel opportunities for enhancing mushroom cultivation biotechnology and medicinal applications. The mitochondrial genomic features are essential for improving agricultural practices and ensuring food security through improved crop productivity, disease resistance, and nutritional qualities. The current knowledge about the mitochondrial genomes of edible mushrooms is summarized in this review, emphasising their significance in both scientific research and practical applications in bioinformatics and medicine.

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“…The last decade was marked by a tremendous increase in the use of medicinal mushrooms as dietary supplements, adjuvants, and functional food [ 1 ]. This millennia-old source of remedies is experiencing a renaissance heavily supported by the development of technology.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Green Extraction Technologies on the Chemical Composition of Medicinal Chaga Mushroom Extracts

Lazić,

Klaus,

Kozarski

et al. 2024

JoF

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The mushroom industry should implement green extraction technologies; however, there is not enough information on the differences between these techniques expressed as the chemical composition of the resulting extract. In this study, selected types of green extraction techniques (GETs) were used on Chaga (Inonotus obliquus) (Fr.) Pilát from Serbia (IS) and Mongolia (IM) to examine the differences that would enable the composition-based technology choices in the mushroom supplement industry. Subcritical water extraction (SWE), microwave-assisted (MW) extraction, and ultrasonic-assisted extraction (VAE) were used to prepare the extracts. SWE was performed at two different temperatures (120 and 200 °C), while 96% ethanol, 50% ethanol, and water were used for MW and VAE. The yield, the content of total phenols, total proteins, and carbohydrates, qualitative and quantitative analysis of phenolic compounds, carbohydrates, including α- and β- and total glucans, and fatty acids, were determined in the obtained extracts. SWE resulted in a significantly higher yield, total polysaccharide, and glucan content than any other technique. Glucose was the most dominant monosaccharide in the SWE samples, especially those extracted at 200 °C. The MW 50% EtOH extracts showed the highest yield of total phenols. Among the tested phenolic compounds, chlorogenic acid was the most dominant. SWE can be recommended as the most efficient method for extracting commercially important compounds, especially glucans and phenols.

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Increasing the production of the bioactive compounds in medicinal mushrooms: an omics perspective

Cited by 19 publications

References 253 publications

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer

Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer

Complete mitochondrial genomes of edible mushrooms: features, evolution, and phylogeny

The Effect of Green Extraction Technologies on the Chemical Composition of Medicinal Chaga Mushroom Extracts

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