Caregiver's behaviour in caring for family members with mental disorders highly influenced the life quality of post-shackle psychiatric patients. This study aimed at determining the determinants of behaviour in the caregiver that affect the life quality of post-shackle patients. The study was conducted using an analytical survey with a cross-sectional study approach. Samples were taken from a population of 63 post-shackle patients and their caregivers in Klaten and Sukoharjo. All seven determinants of caregiver behaviour were analysed by concurrent regression. The independent variables were knowledge, attitudes, behavioural tendencies, subjective norms, self-efficacy, intentions, and social support from the family, while the dependent variable was the life quality of post-stock patients. Data analysis included multiple regression analysis test, t-test, F-test, and R2. The regression test revealed F obtained of 9.624 with a significance value of 0.001 (ρ <0.05) so that H0 was rejected. The determination value was 0.493. Hence, the independent variable in the model could explain 49.3% of variations of changes in the dependent variable. The study concluded that caregiver behaviour, namely the factors of knowledge, attitude, self-efficacy, and caregiver intention, partially determined the quality of life of post-shackle patients in Klaten and Sukoharjo districts.