Increasing the survival of transverse rectus abdominis musculocutaneous flaps with a Botulinum toxin-A injection: A comparison of surgical and chemical flap delay methods

Temiz, Gökhan; Yeşïloğlu, Nebil; Şirinoğlu, Hakan; Akpinar, Ali Cem; Sarıcı, Murat; Filinte, Deniz; Filinte, Gaye Taylan; Bozkurt, Mehmet

doi:10.1016/j.bjps.2016.02.006

Cited by 19 publications

(11 citation statements)

References 22 publications

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“…One of these only reported a qualitative assessment. 10 In the remaining 11 studies, the mean difference between the experimental groups and controls in the area of flap survival was an increase of 24.1% (±12.25%) in the BoNT-A-treated cohort (ranging between 4.23% 22 and 41.16% 13 ). A single study 19 did not detect any difference between cases and controls.…”

Section: Resultsmentioning

confidence: 98%

“…Fourteen studies had a control group, while 3 had an internal control. Four articles referred to random myocutaneous flaps, 9-12 8 to cutaneous flaps (5 random pattern 13-17 and 3 axial 18-20 ), 1 to axial muscle flap, 21 1 to axial fat-cutaneous flap, 22 and 3 to free flaps or vascular anastomosis. 23-25 Fifteen studies used BTX A, 9-17,19,23,25 1 used BoNT-A and BoNT-B, 18 and 1 used only BoNT-B.…”

Section: Resultsmentioning

confidence: 99%

“…24,25 Only Clemens et al proposed BoNT-A injections within a free-flap anastomosis. 23 In the pedicled flaps group, 9 articles reported the use in random-pattern skin flaps 9-17 and 5 in axial flaps. 18-22 The toxin was injected subcutaneously in 3 studies with axial flap 18,20,22 and in 1 study with random flap.…”

Section: Resultsmentioning

confidence: 99%

“…11 Two studies with random flap performed intramuscular administration. 9,10 One study with axial flap 21 compared the efficacy of intramuscular and perivascular injection, showing statistically significant better outcome in muscle necrosis, edema, and inflammation in the perivascular injection group. Five studies used the intradermal technique with random flap.…”

Section: Resultsmentioning

confidence: 99%

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The Use of Botulinum Toxin in Flap Surgery: A Review of the Literature

et al. 2019

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Botulinum neurotoxin-A and botulinum neurotoxin-B have been shown to play a potential role in improving flap survival in animal models. The aim of this study is to review indications as well as to study injection timing, technique, and doses of botulinum neurotoxin-A and botulinum neurotoxin-B in animal models. Seventeen articles describe a total of 266 animals that underwent botulinum toxin injections before or during flap harvesting or vascular anastomosis procedure. All the studies demonstrated a beneficial effect of botulinum toxin administration in flap surgery or vascular anastomosis. Botulinum neurotoxin-A injection was shown to be a reliable approach in reducing vascular complications rate and increasing survival of flaps in animal models. The main conclusions drawn from the study include the following: perivascular injections targeting each vascular pedicle are preferred in cases of free flaps or axial flaps; subdermal injections are favorable in cases of random pattern skin flaps; and injections should be performed 7 days before flap elevation.

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The Use of Botulinum Toxin in Flap Surgery: A Review of the Literature

et al. 2019

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“…The BoNT/A group showed nearly complete survival of the flaps owing to increased perfusion compared with the control group. The protective effects of BoNT/A on flap survival in rats have been independently reported by several research groups . In one study, BoNT/A was used to prevent unfavourable effects of cigarette smoke in Wistar albino rats .…”

Section: Experimental Studies Of Cutaneous Effects Of Botulinum Neuromentioning

confidence: 95%

The non-neuronal and nonmuscular effects of botulinum toxin: an opportunity for a deadly molecule to treat disease in the skin and beyond

Grando

Zachary

2018

Br J Dermatol

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There is growing evidence that botulinum neurotoxins (BoNTs) exhibit biological effects on various human cell types with a host of associated clinical implications. This review aims to provide an update on the non-neuronal and nonmuscular effects of botulinum toxin. We critically analysed recent reports on the structure and function of cellular signalling systems subserving biological effects of BoNTs. The BoNT receptors and intracellular targets are not unique for neurotransmission. They have been found in both neuronal and non-neuronal cells, but there are differences in how BoNT binds to, and acts on, neuronal vs. non-neuronal cells. The non-neuronal cells that express one or more BoNT/A-binding proteins, and/or cleavage target synaptosomal-associated protein 25, include: epidermal keratinocytes; mesenchymal stem cells from subcutaneous adipose; nasal mucosal cells; urothelial cells; intestinal, prostate and alveolar epithelial cells; breast cell lines; neutrophils; and macrophages. Serotype BoNT/A can also elicit specific biological effects in dermal fibroblasts, sebocytes and vascular endothelial cells. Nontraditional applications of BoNT have been reported for the treatment of the following dermatological conditions: hyperhidrosis, Hailey-Hailey disease, Darier disease, inversed psoriasis, aquagenic palmoplantar keratoderma, pachyonychia congenita, multiple eccrine hydrocystomas, eccrine angiomatous hamartoma, eccrine sweat gland naevi, congenital eccrine naevus, Raynaud phenomenon and cutaneous leiomyomas. Experimental studies have demonstrated the ability of BoNT/A to protect skin flaps, facilitate wound healing, decrease thickness of hypertrophic scars, produce an anti-ageing effect, improve a mouse model of psoriasiform dermatitis, and have also revealed extracutaneous effects of BoNT arising from its anti-inflammatory and anticancer properties. BoNTs have a much wider range of applications than originally understood, and the individual cellular responses to the cholinergic impacts of BoNTs could provide fertile ground for future studies.

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Botulinum neurotoxin injection guidelines regarding flap surgeries in breast reconstruction

Lee

Seo

et al. 2022

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Increasing the survival of transverse rectus abdominis musculocutaneous flaps with a Botulinum toxin-A injection: A comparison of surgical and chemical flap delay methods

Cited by 19 publications

References 22 publications

The Use of Botulinum Toxin in Flap Surgery: A Review of the Literature

The Use of Botulinum Toxin in Flap Surgery: A Review of the Literature

The non-neuronal and nonmuscular effects of botulinum toxin: an opportunity for a deadly molecule to treat disease in the skin and beyond

Botulinum neurotoxin injection guidelines regarding flap surgeries in breast reconstruction

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