Increasing the Value of an Alternative Monetary Reinforcer Reduces Cigarette Choice in Adolescents

Cassidy, Rachel N.; Tidey, Jennifer W.; Kahler, Christopher W.; Wray, Tyler B.; Colby, Suzanne M.

doi:10.1093/ntr/ntv033

Cited by 16 publications

(11 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These preclinical choice procedures provide an explicit, albeit simplified, model of the clinical context in which behavioral allocation occurs between drug use and other activities maintained by nondrug reinforcers. Second, these preclinical results are consistent with human laboratory studies demonstrating dose-dependent increases in the choice of the abused drugs cocaine [32,33], methamphetamine [34,35], opiates [36], Δ-9-tetrahydrocannabinol [37], and tobacco cigarettes [38] relative to choice of a nondrug alternative (usually money). Lastly, these results show that simply introducing an alternative nondrug reinforcer attenuates the potency of abused drugs to function as reinforcers compared with their potency in other drug self-administration procedures that do not include a concurrently available alternative reinforcer.…”

Section: Environmental Determinantssupporting

confidence: 73%

Insights from Preclinical Choice Models on Treating Drug Addiction

Banks

Negus

2017

Trends in Pharmacological Sciences

123

View full text Add to dashboard Cite

Substance-use disorders are a global public health problem that arises from behavioral misallocation between drug use and more adaptive behaviors maintained by nondrug alternatives (e.g., food or money). Preclinical drug self-administration procedures that incorporate a concurrently available nondrug reinforcer (e.g., food) provide translationally relevant and distinct dependent measures of behavioral allocation (i.e., to assess the relative reinforcing efficacy of the drug) and behavioral rate (i.e., to assess motor competence). In particular, preclinical drug versus food 'choice' procedures have produced increasingly concordant results with both human laboratory drug self-administration studies and double-blind placebo-controlled clinical trials. Accordingly, here we provide a heuristic framework of substance-use disorders based on a behavioral-centric perspective and recent insights from these preclinical choice procedures. Keywordschoice; addiction; preclinical model; drug self-administration; substance-use disorder Trends Substance-use disorders (i.e., drug addiction) are increasingly being conceptualized as disorders of behavioral misallocation between drug and nondrug reinforcers.Preclinical drug versus food choice procedures are increasingly being utilized to elucidate environmental, pharmacological, and biological mechanisms associated with this behavioral misallocation.Preclinical drug versus food choice procedures provide distinct dependent measures that dissociate drug reinforcement (i.e., allocation of behavior) from motor competence (i.e., rate of behavior). Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptAlternative nondrug reinforcer availability and temporal delivery impact behavioral allocation.Preclinical drug versus food choice procedures are being developed for abused drugs other than cocaine.Biological variables are an emerging as important determinants of behavioral allocation between drug and nondrug reinforcers. Drug AddictionDrug addiction is an insidious and global public health problem. . Furthermore, six of the 11 diagnostic criteria used for substance-use disorders are based on the allocation of behavior towards the procurement and use of the substance compared with other behaviors maintained by nondrug and presumably more adaptive alternative reinforcers (e.g., food, money, or social commendation). Thus, the diagnosis of substance-use disorders takes a behavioral-centric perspective and implies that such disorders arise from behavioral misallocat...

show abstract

Section: Environmental Determinantssupporting

confidence: 73%

Insights from Preclinical Choice Models on Treating Drug Addiction

Banks

Negus

2017

Trends in Pharmacological Sciences

123

View full text Add to dashboard Cite

show abstract

“…58 In behavioral economic laboratory studies, responses of vulnerable subpopulations to tobacco products can be investigated by comparing self-administration rates, product choice, or sensitivity to cost (either financial or in terms of response requirement) among groups. For example, Cassidy et al 59 examined adolescent smoking behavior using a procedure in which participants were given the opportunity to make choices between receiving cigarette puffs versus a monetary reinforcer that varied in value across sessions. Similar to data from adults, adolescents’ choices for cigarette puffs decreased as a function of increasing monetary reinforcement; however, boys were more sensitive to this effect than girls, suggesting that girls may over-value cigarette reinforcement compared to boys.…”

Section: Resultsmentioning

confidence: 99%

Behavioral Economic Laboratory Research in Tobacco Regulatory Science

Tidey¹,

Cassidy²,

Miller³

et al. 2016

tobacco reg sci

Self Cite

View full text Add to dashboard Cite

Objectives Research that can provide a scientific foundation for the United States Food and Drug Administration (FDA) tobacco policy decisions is needed to inform tobacco regulatory policy. One factor that affects the impact of a tobacco product on public health is its intensity of use, which is determined, in part, by its abuse liability or reinforcing efficacy. Behavioral economic tasks have considerable utility for assessing the reinforcing efficacy of current and emerging tobacco products. Methods This paper provides a narrative review of several behavioral economic laboratory tasks and identifies important applications to tobacco regulatory science. Results Behavioral economic laboratory assessments, including operant self-administration, choice tasks and purchase tasks, can be used generate behavioral economic data on the effect of price and other constraints on tobacco product consumption. These tasks could provide an expedited simulation of the effects of various tobacco control policies across populations of interest to the FDA. Conclusions Tobacco regulatory research questions that can be addressed with behavioral economic tasks include assessments of the impact of product characteristics on product demand, assessments of the abuse liability of novel and potential modified risk tobacco products (MRTPs), and assessments of the impact of conventional and novel products in vulnerable populations.

show abstract

“…One limitation of many traditional preclinical self-administration procedures when evaluating potential pharmacotherapies for tobacco use disorder has been the integration of control experiments that allow for a distinction to be made between drug effects that selectively decrease the rate of responding for a self-administered drug as opposed to effects that produce generalized suppression of behavior. However, self-administration studies in humans have a long history of using choice experiments to examine a variety of abused drugs, including nicotine (Johnson and Bickel, 2003;Bisaga et al, 2007;Odum and Baumann, 2007;Stoops et al, 2011;Green and Lawyer, 2014;Cassidy et al, 2015). In preclinical choice procedures, in addition to a rate-dependent measure of responding, rate-independent data about the allocation of responses for the drug as opposed to the nondrug reinforcer can also be collected (see Banks and Negus, 2017, for review).…”

Section: Preclinical Methods For Evaluatingmentioning

confidence: 99%