Increasing time interval and decreasing allergen dose interval improves <i>ex vivo</i> desensitization of human blood basophils

Christensen, S K Witting; Krohn, Inge Kortekaas; Thuraiaiyah, J; Skjold, Tina; Schmid, Johannes Martin; Hoffmann, Hans Jürgen

doi:10.1002/cyto.b.21377

Cytometry Part B Clinical

2016

DOI: 10.1002/cyto.b.21377

|View full text |Cite

Increasing time interval and decreasing allergen dose interval improves ex vivo desensitization of human blood basophils

S K Witting Christensen

Inge Kortekaas Krohn

J Thuraiaiyah

et al.

Abstract: Sequential desensitization ex vivo effectively attenuates the basophil response to allergen. Increasing the time spent at each step improves desensitization. This protocol could be valuable for investigation the mechanism of desensitization. © 2016 International Clinical Cytometry Society.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 35 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Temporal Modulation of Drug Desensitization Procedures

Stan

2022

CIMB

View full text Add to dashboard Cite

Drug hypersensitivity reactions are an unavoidable clinical consequence of the presence of new therapeutic agents. These adverse reactions concern patients afflicted with infectious diseases (e.g., hypersensitivity to antibiotics), and with non-infectious chronic diseases, such as in cancers, diabetes or cystic fibrosis treatments, and may occur at the first drug administration or after repeated exposures. Here we revise recent key studies on the mechanisms underlying the desensitization protocols, and propose an additional temporal regulation layer that is based on the circadian control of the signaling pathway involved and on the modulation of the memory effects established by the desensitization procedures.

show abstract

Temporal Modulation of Drug Desensitization Procedures

Stan

2022

CIMB

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Increasing time interval and decreasing allergen dose interval improves ex vivo desensitization of human blood basophils

Cited by 1 publication

References 35 publications

Temporal Modulation of Drug Desensitization Procedures

Temporal Modulation of Drug Desensitization Procedures

Contact Info

Product

Resources

About