Increasing trend in the incidence of cervical cancer among the elderly in Korea: A population-based study from 1993 to 2002

Jo, Hoenil; Jeon, Yung Jin; Hwang, Soon Young; Shin, Hai‐Rim; Song, Yong Sang; Kang, Soon Beom; Lee, Hyo Pyo; Kim, Jae Weon

doi:10.1080/02841860601134493

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…In Korea, cervical cancer is a major health concern for women, accounting for 9.8% of new female cancer cases. Although incidence and mortality rates have been decreasing, the incidence of cervical cancer in the elderly is increasing [ 10 ]. However, most of the treatment failures in advanced cervical cancersoriginate from the development of radioresistance, a problem that we have not yet overcome.…”

Section: Introductionmentioning

confidence: 99%

Suppressor of Cytokine Signaling (SOCS) Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical Cancer Cells

Kim

et al. 2015

PLoS ONE

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Suppressor of cytokine signaling (SOCS) family is an important negative regulator of cytokine signaling and deregulation of SOCS has been involved in many types of cancer. All cervical cancer cell lines tested showed lower expression of SOCS1, SOCS3, and SOCS5 than normal tissue or cell lines. The immunohistochemistry result for SOCS proteins in human cervical tissue also confirmed that normal tissue expressed higher level of SOCS proteins than neighboring tumor. Similar to the regulation of SOCS in other types of cancer, DNA methylation contributed to SOCS1 downregulation in CaSki, ME-180, and HeLa cells. However, the expression of SOCS3 or SOCS5 was not recovered by the inhibition of DNA methylation. Histone deacetylation may be another regulatory mechanism involved in SOCS1 and SOCS3 expression, however, SOCS5 expression was neither affected by DNA methylation nor histone deacetylation. Ectopic expression of SOCS1 or SOCS3 conferred radioresistance to HeLa cells, which implied SOCS signaling regulates the response to radiation in cervical cancer. In this study, we have shown that SOCS expression repressed by, in part, epigenetically and altered SOCS1 and SOCS3 expression could contribute to the radiosensitive phenotype in cervical cancer.

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Section: Introductionmentioning

confidence: 99%

Suppressor of Cytokine Signaling (SOCS) Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical Cancer Cells

Kim

et al. 2015

PLoS ONE

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“…However, elderly Korean women have lower level of Pap smear screening rates, higher probability of abnormal Pap smears, higher incidence of cervical cancer, and a relatively higher proportion of advanced stage cervical cancer than western elderly women 11,17-19). Accordingly, there is no direct evidence to support discontinuation of Pap screening in older women and consensus recommendations eastablished for the period of the discontinuation do not exist yet.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with the Use of Uterine Cervical Cancer Screening Services in Korean Elderly Women

Park

Lee

2012

Korean J Fam Med

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BackgroundThe Papanicolaou (Pap) smear test is an effective screening test for the early detection of uterine cervical cancer. The Pap test still plays an important role in Korean elderly women, as uterine cervical cancer remains a frequent form of cancer and an important cause of death. However, the participation rate and other factors related to the Pap test in Korean elderly women have been studied insufficiently.MethodsThis study included 654 individuals aged 65 and over who completed a cervical cancer screening questionnaire from the Third Korean National Health and Nutrition Examination Survey 2005. Using multiple logistic regression, odds ratios and confidence intervals for the association between attendance of the Pap test and sociodemographic or health-related factors were calculated.ResultsOne hundred and eleven individuals (17.0%) of the study population showed compliance with Pap testing within the previous 2 years. We recognized that the most elderly women (75 years and over) or those with lower levels of education were less likely to have had the test.ConclusionPrimary health care providers need to make efforts to improve attendance rates of Pap smear screening in Korean elderly women, individually taking into account previous Pap results, life expectancy, risk factors for cervical cancer, and preferences. More attention will especially be needed among the eldest elderly or less educated elderly women.

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“U” shape of age-specific prevalence of high-risk human papillomavirus infection in women attending hospitals in Shanghai, China

Xue

Zhang

Chen

et al. 2009

European Journal of Obstetrics & Gynecology and Reproductiv

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Increasing trend in the incidence of cervical cancer among the elderly in Korea: A population-based study from 1993 to 2002

Cited by 5 publications

References 20 publications

Suppressor of Cytokine Signaling (SOCS) Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical Cancer Cells

Suppressor of Cytokine Signaling (SOCS) Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical Cancer Cells

Factors Associated with the Use of Uterine Cervical Cancer Screening Services in Korean Elderly Women

“U” shape of age-specific prevalence of high-risk human papillomavirus infection in women attending hospitals in Shanghai, China

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