Increasing Use of Contralateral Prophylactic Mastectomy for Breast Cancer Patients: A Trend Toward More Aggressive Surgical Treatment

Tuttle, Todd M.; Habermann, Elizabeth B.; Grund, Erin; Morris, Todd J.; Virnig, Beth A

doi:10.1200/jco.2007.12.3141

Cited by 607 publications

(439 citation statements)

References 37 publications

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“…Mastectomy rates did not vary by diagnostic year in the present study. This is in contrast to results from U.S. SEER data that indicate a continuing decline in mastectomy rates from 2000 but with the possibility of an upturn during 2005(Fisher et al, 1995Tuttle et al, 2007;Katipamula et al, 2009;Dragun et al, 2012a;2012b). This was supported by some regional and institutional data from the U.S. and evidently was influenced by an upturn in contra-lateral prophylactic mastectomies (Tuttle et al, 2007;Katipamula et al, 2009;Dragun et al, 2012a;2012b).…”

Section: Discussioncontrasting

confidence: 61%

“…Statement and reviews of evidence from randomized trials (Abrams et al, 1995;Fisher et al, 1995), mastectomy rates declined markedly in the U.S. (Lazovich et al, 1991;Lazovich et al, 1997;Habermann et al, 2010), Canada, (Gaudette et al, 2004) European countries, (Zorzi et al, 2006), although with a more recent upturn suggested in some North American localities (Tuttle et al, 2007;Katipamula et al, 2009;Dragun et al, 2012a;2012b). Australian data also showed a trend away from mastectomy towards breast conserving surgery both nationally and in a number of jurisdictions (Hill et al, 1990;1994;Byrne et al, 1993;South Australian Cancer Registry, 2000;Cuncins-Hearn et al, 2006;Kricker, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Factors Predictive of Treatment by Australian Breast Surgeons of Invasive Female Breast Cancer by Mastectomy rather than Breast Conserving Surgery

Roder¹,

Zorbas²,

Kollias³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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With major city residence as the reference category, the relative rate (95% confidence limits) of mastectomy was 1.03 (0.99, 1.07) for women from inner regional areas and 1.05 (1.01, 1.10) for those from more remote areas. Low annual surgeon case load (≤10) was predictive of mastectomy, with a relative rate of 1.08 (1.03, 1.14) when compared with higher case loads. Tumour size was also predictive, with a relative rate of 1.05 (1.01, 1.10) for large cancers (40+ mm) compared with smaller cancers (<30 mm). These associations were confirmed in multiple logistic regression analysis. Conclusions: Results confirm previous studies showing higher mastectomy rates for residents of more remote areas, those treated by surgeons with low case loads, and those with large cancers. Reasons require further study, including possible effects of surgeon and woman's choice and access to radiotherapy services.

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Section: Discussioncontrasting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Factors Predictive of Treatment by Australian Breast Surgeons of Invasive Female Breast Cancer by Mastectomy rather than Breast Conserving Surgery

Roder¹,

Zorbas²,

Kollias³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…However, the perception was that a bilateral mastectomy would reduce breast cancer recurrence. Contralateral prophylactic mastectomy greatly lowers the risk of developing cancer in the healthy breast, but there is no evidence of an increase in overall survival as an outcome (Tuttle, Habermann, Grund, Morris, Virnig 2007).The risk of systemic metastases from the primary cancer often exceeds the risk of developing a contralateral breast cancer (Yi, Meric-Bernstam, Middleton, Arun, Bedrosian, Babiera et al 2009). It is not clear from the interview data if women understood the recurrence risk.…”

Section: Discussionmentioning

confidence: 99%

Exploring patient experiences of neo-adjuvant chemotherapy for breast cancer

Beaver

Williamson

Briggs

2016

European Journal of Oncology Nursing

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“…5 Contralateral prophylactic mastectomy is chosen for patients with unilateral breast cancer to prevent possible cancer in the opposite breast. [6][7][8] The procedure does not offer a survival benefit but is performed for local control of breast cancer, to reduce risk and to provide symmetry.…”

mentioning

confidence: 99%

Meta-analysis of sentinel lymph node biopsy at the time of prophylactic mastectomy of the breast

Zhou

Dai

et al. 2011

Can J Surg

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Background: Prophylactic mastectomy is performed to decrease the risk of breast cancer in women at high risk for the disease. The benefit of sentinel lymph node biopsy (SLNB) at the time of prophylactic mastectomy is controversial, and we performed a meta-analysis of the reported data to assess that benefit. Methods:We searched MEDLINE, EMBASE and the Cochrane Library databases from January 1993 to December 2009 for studies on patients who underwent SLNB at the time of prophylactic mastectomy. Two reviewers independently evaluated all the identified papers, and only retrospective studies were included. We used a mixedeffect model to combine data. Results:We included 6 studies in this review, comprising a total study population of 1251 patients who underwent 1343 prophylactic mastectomies. Of these 1343 pooled prophylactic mastectomies, the rate of occult invasive cancer (21 cases) was 1.7% (95% confidence interval [CI] 1.1%-2.5%), and the rate of positive SLNs (23 cases) was 1.9% (95% CI 1.2%-2.6%). In all, 36 cases (2.8%, 95% CI 2.0%-3.8%) led to a significant change in surgical management as a result of SLNB at the time of prophylactic mastectomy. In 17 cases, patients with negative SLNs were found to have invasive cancer at the time of prophylactic mastectomy and avoided axillary lymph node dissection (ALND). In 19 cases, patients with positive SLNBs were found not to have invasive cancer at the time of prophylactic mastectomy and needed a subsequent ALND. Of the 23 cases with positive SLNs, about half the patients had locally advanced disease in the contralateral breast. Conclusion:Sentinel lymph node biopsy is not suitable for all patients undergoing prophylactic mastectomy, but it may be suitable for patients with contralateral, locally advanced breast cancer.Contexte : La mastectomie prophylactique vise à réduire le risque de cancer du sein chez les femmes à risque élevé. L'avantage de la biopsie du ganglion lymphatique sentinelle (BGLS) au moment de la mastectomie prophylactique suscite la controverse et nous avons procédé à une méta-analyse des données qui ont fait l'objet de rapports afin d'évaluer l'avantage en question. Méthodes :Nous avons cherché dans les bases de données MEDLINE, EMBASE et la Bibliothèque Cochrane, de janvier 1993 à décembre 2009, des études portant sur des patientes qui ont subi une BGLS au moment de la mastectomie prophylactique. Deux examinateurs ont évalué indépendamment toutes les études repérées et nous avons inclus seulement les études rétrospectives. Nous avons utilisé un modèle à effets mixtes pour combiner les données.Résultats : Nous avons inclus dans cette analyse 6 études regroupant une population totale de 1251 patientes qui ont subi 1343 mastectomies prophylactiques. Parmi ces 1343 mastectomies prophylactiques regroupées, le taux de cancer envahissant occulte (21 cas) s'est établi à 1,7 % (intervalle de confiance [IC] à 95 %, 1,1 %-2,5 %) et le taux de GLS positifs (23 cas) a atteint 1,9 % (IC à 95 %, 1,2 %-2,6 %). Au total, les constatations dans 36 cas (2,8 %, IC ...

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Increasing Use of Contralateral Prophylactic Mastectomy for Breast Cancer Patients: A Trend Toward More Aggressive Surgical Treatment

Abstract: The use of contralateral prophylactic mastectomy in the United States more than doubled within the recent 6-year period of our study. Prospective studies are needed to understand the decision-making processes that have led to more aggressive breast cancer surgery.

Cited by 607 publications

References 37 publications

Factors Predictive of Treatment by Australian Breast Surgeons of Invasive Female Breast Cancer by Mastectomy rather than Breast Conserving Surgery

Factors Predictive of Treatment by Australian Breast Surgeons of Invasive Female Breast Cancer by Mastectomy rather than Breast Conserving Surgery

Exploring patient experiences of neo-adjuvant chemotherapy for breast cancer

Meta-analysis of sentinel lymph node biopsy at the time of prophylactic mastectomy of the breast

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