Incredible Role of Glycerol in Multicomponent Synthesis of 2,3-Dihydroquinazoline-4(1H)-ones and 1-Amidoalkyl-2-naphthols

Abstract

Abstract. An efficient and green synthesis of 1-amidoalkyl-2-naphthols via one-pot three-component condensation of aromatic aldehydes, acetamide and 2-naphthol in the presence of catalytic amounts of glycerosulfonic acid in glycerol as a green solvent was elaborated. Also a simple method for the one-pot threecomponent synthesis of 2,3-dihydroquinazoline-4(1H)-ones using of isatoic anhydride, aldehydes and ammonium acetate in the presence of glycerol as a green catalyst and solvent was described. In this light we introduced the brilliant and valuable role of glycerol in the synthesis of 2,3-dihydroquinazoline-4(1H)-ones and 1-amidoalkyl-2-naphthols.

Sulfuric acid heterogenized on magnetic Fe3O4 nanoparticles: A new and efficient magnetically reusable catalyst for condensation reactions

“…Chemicals were purchased from Fisher and Merck. The reagents and solvents used in this work were obtained from Sigma-Aldrich, Fluka or Merck and used without [49] 2 Glycerosulfonic acid Glycerol, 80°C 360 97 [50] 3 Silica sulfuric acid H 2 O,80°C 180 81 [51] 4…”

2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design

“…The absence of catalyst again afforded 74-97% yield but in longer reaction times (1-6 h). [193][194][195][196][197] Urea or thiourea was used in the multi-component synthesis of DHQs as the ammonia surrogate under catalyst-free conditions. 198 A very efficient and fast synthesis of DHQs was attempted under both catalyst-and solvent-free conditions (>90% yield, in 3-10 min).…”