Incremental Effect of Mitral Regurgitation on Left Atrial Dysfunction and Atrioventricular Interaction in Hypertensive Patients by MRI

Abstract

BackgroundMitral regurgitation may occur when hypertension causes left ventricular (LV) and left atrial (LA) remodeling. However, its role in LA function in hypertensive patients remains unclear.PurposeTo explore how mitral regurgitation affects LA function in hypertension and to investigate atrioventricular interaction in hypertensive patients with mitral regurgitation.Study TypeRetrospective.PopulationA total of 193 hypertensive cases and 64 controls.Field Strength/SequenceA 3.0 T/balanced steady‐state free precession.AssessmentLA volume (LAV), LA strain (reservoir, conduit, and active), LA ejection fraction, and LV strain (global peak longitudinal [GLS], circumferential [GCS], and radial strain [GRS]) were evaluated and compared among groups. Regurgitant fraction (RF) was evaluated in regurgitation patients and used to subdivide patients into mild (RF: 0%–30%), moderate (RF: 30%–50%), and severe (RF: >50%) regurgitation categories.Statistical TestsOne‐way analysis of variance, Spearman and Pearson's correlation coefficients (r), and multivariable linear regression analysis. A P value <0.05 was considered statistically significant.ResultsHypertensive patients without mitral regurgitation showed significantly impaired LA reservoir and conduit functions and significantly decreased LV GLS but preserved pump function and LAV compared to controls (P = 0.193–1.0). Hypertensive cases with mild regurgitation (N = 22) had significantly enlarged LAV and further reduced LA reservoir function, while the group with moderate regurgitation (N = 20) showed significantly reduced LA pump function, further impaired conduit function, and significantly reduced LV strain. The severe regurgitation (N = 13) group demonstrated significantly more severely impaired LA and LV functions and LAV enlargement. Multivariable linear regression showed that regurgitation degree, GRS, GCS, and GLS were independently correlated with the LA reservoir, conduit, and active strain in hypertensive patients with mitral regurgitation.Data ConclusionMitral regurgitation may exacerbate LA and LV impairment in hypertension. Regurgitation degree, LV GRS, GCS, and GLS were independent determinants of the LA strain in hypertensive patients with mitral regurgitation, which demonstrated atrioventricular interaction.Evidence Level4.Technical EfficacyStage 3.

Editorial for “Incremental Effect of Mitral Regurgitation on Left Atrial Dysfunction and Atrioventricular Interaction in Hypertensive Patients by MRI”

“…5 In this issue of JMRI, the authors present "Abnormal Atrio-ventricular Interaction and Left Atrial Dysfunction in Essential Hypertensive Patients with Mitral Regurgitation: Evaluation by Cardiac Magnetic Resonance Feature Tracking" a retrospective cohort study examining the influence of essential hypertension and MR on MR-FT derived parameters of LA and LV strain. 6 A total of 257 patients were enrolled, including 64 healthy controls, 138 patients with essential hypertension (HTN/MRÀ) and 55 patients with both essential hypertension and MR of varying degrees (HTN/MR+). Cardiac magnetic resonance imaging (MRI) evaluation consisted of routine volumetric and SV assessment, as well as cine derived strain parameters.…”