Incremental sheet forming (ISF) is an advanced flexible manufacturing process to produce complex 3D products. Unlike the conventional stamping process, ISF does not require any high cost dedicated dies. However, numerical computation for large-size ISF processes is time-consuming, and its accuracy for spring back due to unclamping tools after ISF cannot satisfy industrial demand. In this paper, an advanced numerical model considering complicated forming tool paths, trimming, and spring back was developed to efficiently simulate the multi-stage deformation phenomena of incremental sheet forming processes. Numerical modeling accuracy and efficiency are investigated considering the influence of tool path, material properties of the blank, mesh size, and boundary conditions. Through a series of case studies and comparisons with experimental results, it is observed that the numerical model with kinematics material properties and a moderate element size (5 mm) may reproduce the deformation characteristics of ISF with good accuracy and can obtain practical efficiency for a large-size ISF part.