Incremento de los parámetros de estrés oxidativo salival en pacientes con diabetes tipo 2: relación con la enfermedad periodontal

Arana, Carlos; Fernández, Antonio J. Sánchez; Gómez‐Moreno, Gerardo; Portillo, Cristóbal Morales; Serrano-Olmedo, Isabel; Mayor, M. Carmen de la Cuesta; Hernández, Tomás Martín

doi:10.1016/j.endinu.2017.03.005

Cited by 34 publications

(9 citation statements)

References 22 publications

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“…DM and periodontal complications have a mutually reinforcing effect on each other: DM increases the ruthlessness, occurrence and progression of periodontal disease while periodontal disease may accentuate the severity of DM by deteriorating the level of glycemic control in the blood (Meenawat et al 2013 ). Moreover, studies have shown that periodontal inflammation is significantly increased in subjects with longer disease course, poor metabolic control (Arana et al 2017 ) and DM complications (Preshaw et al 2012 ). This makes it more dominant in T1DM patients whereas T2DM are more prone to develop tumors at different sites, including the salivary glands (Suba et al 2005 ).…”

Section: Salivary Gland Diseases and Diabetes Mellitusmentioning

confidence: 99%

“…Thus, IR should be taken seriously in dental clinics as at this stage of DM it could lead to oral health manifestations (Kolodziej et al 2017 ). Oxidative stress marker, oxidized glutathione/reduced glutathione (GSSG/GSH), was shown to be increased in the saliva of T2DM patients compared to control group (Arana et al 2006 , 2017 ). Additionally, a significant increase in oxidative stress levels was found in the T2DM group with poor metabolic control vs the T2DM group with good metabolic control.…”

Section: Salivary Gland Diseases and Diabetes Mellitusmentioning

confidence: 99%

“…Additionally, a significant increase in oxidative stress levels was found in the T2DM group with poor metabolic control vs the T2DM group with good metabolic control. This increase in oxidative stress was positively correlated with poor periodontal health as the Community Periodontal Index (CPI) was the highest in T2DM group with poor metabolic control as compared with T2DM group with good metabolic control and the control group respectively (Arana et al 2017 ). An increase in total antioxidant power (TAOP) was reported in the saliva of T1DM patients compared to the control (Astaneie et al 2005 ).…”

Section: Salivary Gland Diseases and Diabetes Mellitusmentioning

confidence: 99%

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Salivary gland proteins alterations in the diabetic milieu

et al. 2021

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Salivary glands are considered the chief exocrine glands of the mouth and physiologically contribute to the maintenance of the homeostasis of the oral cavity. They consist of the parotid, submandibular and sublingual glands, which come in pairs and are collectively called the major glands, and the minor glands, which are much smaller and are dispersed throughout the buccal cavity. Salivary glands are distinguished by their size, amount of saliva secretion and their location in the oral cavity. Salivary glands pathophysiology has been a subject of interest in various worldwide metabolic disorders, including diabetes mellitus. Diabetes mellitus (DM), a global health concern, with a pathological imprint involved in vasculature, promotes microvascular and macrovascular complications among which periodontitis ranks sixth. Indeed, DM has also been directly associated with oral health lesions. Specifically, salivary glands in the context of diabetes have been a focal point of study and emphasis in the research field. There is evidence that relates salivary secretion content and diabetes progression. In this review, we present all the reported evidence of the deregulation of specific salivary proteins associated with the progression of diabetes in parallel with changes in salivary gland morphology, cellular architecture, and salivary secretion and composition more generally.

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Section: Salivary Gland Diseases and Diabetes Mellitusmentioning

confidence: 99%

Section: Salivary Gland Diseases and Diabetes Mellitusmentioning

confidence: 99%

Section: Salivary Gland Diseases and Diabetes Mellitusmentioning

confidence: 99%

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Salivary gland proteins alterations in the diabetic milieu

et al. 2021

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“…Arana et al [48] evaluated the levels of GSH-Px in the saliva of patients with diabetes mellitus type 2 (DM2) and healthy nondiabetic patients in the presence of periodontal disease. They determined that the salivary GSH-Px levels in the diabetic group with good metabolic control was significantly higher than the control group and the diabetic group with poor metabolic control, and also patients with poor metabolic control in comparison with the control group and well-controlled diabetic groups have worst periodontal health and lowest saliva GPx levels [48]. Authors suggested that poor metabolic control in DM2 patients is associated with lower levels of salivary GSH-Px and worse periodontal health [48].…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…They determined that the salivary GSH-Px levels in the diabetic group with good metabolic control was significantly higher than the control group and the diabetic group with poor metabolic control, and also patients with poor metabolic control in comparison with the control group and well-controlled diabetic groups have worst periodontal health and lowest saliva GPx levels [48]. Authors suggested that poor metabolic control in DM2 patients is associated with lower levels of salivary GSH-Px and worse periodontal health [48]. On the other hand, Duarte et al [47] evaluated the gene expression of GSH-Px1 in the gingival tissue of poorly and well-controlled type 2 diabetic subjects with CP.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Periodontal Health and Disease in Glutathione Peroxidase

Dede¹

2020

Glutathione System and Oxidative Stress in Health and Disease

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Periodontal diseases are chronic, multifactorial inflammatory diseases that affect more than 10% of the world population. There are two general forms of periodontal diseases including gingivitis (reversible inflammation and confined with gingiva form) and periodontitis (irreversible, destruction form). Several studies have reported that periodontal disease was associated with a decreased antioxidant capacity and elevated oxidative damage within the oral cavity. Glutathione peroxidase (GSH-Px) is an important enzymatic antioxidant that protects periodontal tissues against oxidative stress. Hitherto, there is contradictory evidence concerning the relationship between the levels of GSH-Px and the periodontal status. Various studies have demonstrated that GSH-Px levels in different biological fluids increased, decreased, or are unaltered in individuals with periodontal disease. This discrepancy might be explained either by different determination protocols/assays applied among the studies or various dynamic processes of the periodontal disease progression. In this section, GSH-Px levels are summarized in the periodontal health and disease including the presence and absence of systemic disease, medication, wound healing, and smoking.

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The assessment of glutathione, glutathione peroxidase, glutathione reductase, and oxidized glutathione in patients with periodontitis—A systematic review and meta‐analysis

Mohideen,

Krithika,

Jeyanthikumari

et al. 2024

Clinical & Exp Dental Res

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ObjectiveThe present systematic review explored the involvement of enzymatic and nonenzymatic antioxidants in periodontitis, drawing from established literature.Materials and MethodsThe research approach encompassed an extensive electronic search from 2000 to 2023 across databases such as PubMed, Science Direct, and Wiley Online Library and cross‐referencing using specific keywords.ResultsThe initial literature exploration generated a total of 766 articles. After thoroughly examining the abstracts, 693 articles were excluded from consideration due to duplication and lack of relevance to the central research inquiry. Following that, 73 articles were left for in‐depth evaluation. Following a qualitative assessment, 35 studies that satisfied the inclusion criteria were chosen, while 38 were removed for not meeting the necessary standards. Within this selection, a meta‐analysis was conducted on 11 articles that provided consistent data for quantitative synthesis. Specifically, the analysis of glutathione (GSH) levels in serum samples revealed a standardized mean difference (SMD) of −5.552 µg/mL (CI 95%: −9.078 to −2.026; P‐0.002). In contrast, the analysis of glutathione peroxidase (GPx) enzymes in gingival crevicular fluid (GCF) samples displayed an overall SMD of 2.918 ng/µL (CI 95%: 0.372–5.465; P‐0.025), while salivary samples exhibited an overall SMD value of 0.709 U/l (95% CI: −1.907–3.325; P‐0.596) which is of insignificant.ConclusionThe systematic review findings suggest a notable decrease in antioxidant enzymes across various systemic biological samples among patients with periodontitis, contrasting with the results from gingival tissue samples meta‐analysis of GPx enzyme.

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Incremento de los parámetros de estrés oxidativo salival en pacientes con diabetes tipo 2: relación con la enfermedad periodontal

Cited by 34 publications

References 22 publications

Salivary gland proteins alterations in the diabetic milieu

Salivary gland proteins alterations in the diabetic milieu

Periodontal Health and Disease in Glutathione Peroxidase

The assessment of glutathione, glutathione peroxidase, glutathione reductase, and oxidized glutathione in patients with periodontitis—A systematic review and meta‐analysis

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