Incretin-Based Therapy for Prevention of Diabetic Vascular Complications

Mima, Akira

doi:10.1155/2016/1379274

Cited by 31 publications

(27 citation statements)

References 97 publications

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“…Diabetic vascular complications are the most common cause of mortality and morbidity worldwide, with numbers of affected individuals steadily increasing [2]. Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and remains a major cause of preventable blindness [3].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy

Uyar

Balkarlı

Erol

et al. 2016

Journal of Diabetes Research

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Background and Objectives. Nailfold capillaroscopy is an easy and noninvasive technique used to investigate dermal microvasculature. Traditional investigations of vascularity do not detect changes until they are well-established in type 2 diabetics. The objective of the current study was to evaluate nailfold capillaries in type 2 diabetes mellitus patients and to determine the association of retinopathy with changes in the nailfold capillaries. Materials and Methods. Capillaroscopic findings by nailfold capillaroscopy and fundoscopic examinations were assessed in 216 patients with type 2 diabetes mellitus and 101 healthy controls included in this prospective study. Results. Retinopathy was detected in 43.05% of diabetic patients (n = 93). Capillaroscopic findings including tortuosity (p < 0.001), bushy capillary (p < 0.001), neoformation (p < 0.001), bizarre capillary (p < 0.001), microhemorrhage (p = 0.001), capillary ectasia (p = 0.002), and aneurysm (p = 0.004) were significantly higher in diabetic group than control group. In logistic regression analysis, only tortuosity was shown significant (OR, 2.16; p = 0.036). There was also a significant relation between diabetes duration and most of the capillaroscopic findings. Conclusion. Capillaroscopic changes were found to be correlated with diabetic retinopathy, in particular with longer disease duration in our study. Capillaroscopic imaging could be a useful new technique for assessment of diabetic microvascular changes.

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Section: Introductionmentioning

confidence: 99%

Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy

Uyar

Balkarlı

Erol

et al. 2016

Journal of Diabetes Research

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“…Incretin-based therapy seems very promising for the prevention of diabetic vascular complications (Mima 2016). The potential for GLP-1RAs to enhance vascular function has been demonstrated in several studies (Nystrom et al 2004, Smits et al 2015, Sufiun et al 2015Zhou et al 2015.…”

Section: Glp-1ras and Blood Flow To Bonementioning

confidence: 99%

Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists

Mabilleau

Pereira

Chenu

2018

Journal of Endocrinology

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Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications. In addition, some anti-diabetic therapies for T2DM can have notable detrimental skeletal effects. Thus, an appropriate therapeutic strategy for T2DM should not only be effective in re-establishing good glycaemic control but also in minimising skeletal complications. There is increasing evidence that glucagon-like peptide-1 receptor agonists (GLP-1RAs), now greatly prescribed for the treatment of T2DM, have beneficial skeletal effects although the underlying mechanisms are not completely understood. This review provides an overview of the direct and indirect effects of GLP-1RAs on bone physiology, focusing on bone quality and novel mechanisms of action on the vasculature and hormonal regulation. The overall experimental studies indicate significant positive skeletal effects of GLP-1RAs on bone quality and strength although their mechanisms of actions may differ according to various GLP-1RAs and clinical studies supporting their bone protective effects are still lacking. The possibility that GLP-1RAs could improve blood supply to bone, which is essential for skeletal health, is of major interest and suggests that GLP-1 anti-diabetic therapy could benefit the rising number of elderly T2DM patients with osteoporosis and high fracture risk.

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“…It is likely that GLP-1 agonists also exert a neuroprotective effect by reducing vascular risk factors. Incretin therapy has been shown to improve micro and macro-vascular complications of diabetes by reducing cerebral ischaemia [62]. In addition to being effective in PD animal models, treatments with GLP-1 analogues have also resulted in improvements in memory impairment by preventing synapse loss in AD animal models [63,64], with Liraglutide being shown to have reduced the soluble Aβ oligomer [63].…”

Section: The Role Of Gip Glp-1 and Dpp4mentioning

confidence: 99%

Parkinson';s Disease, Diabetes and Cognitive Impairment

Ashraghi¹,

Pagano²,

Polychronis³

et al. 2016

EMI

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Patents published in the last 5 years could be used in novel approaches to Parkinson's treatment by targeting specific pathophysiology proteins, such as Nurr1, PINK1 and NrF2, while patents to improve penetration of the blood brain barrier could allow improved efficacy of existing treatments. Conclusion:Further studies using GLP-1 agonists and DPP-4 inhibitors to treat PD are warranted as they have shown promise.

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Incretin-Based Therapy for Prevention of Diabetic Vascular Complications

Cited by 31 publications

References 97 publications

Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy

Assessment of the Relationship between Diabetic Retinopathy and Nailfold Capillaries in Type 2 Diabetics with a Noninvasive Method: Nailfold Videocapillaroscopy

Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists

Parkinson';s Disease, Diabetes and Cognitive Impairment

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