Incubation of sucrose craving: effects of reduced training and sucrose pre-loading

Grimm, Jeffrey W.; Fyall, Amber; Osincup, Dan

doi:10.1016/j.physbeh.2004.10.011

Cited by 117 publications

(128 citation statements)

References 24 publications

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“…Consistent with previous studies on incubation of nondrug sucrose craving (Grimm et al, 2005;Li and Frantz, 2010;Uejima et al, 2007), we observed incubation of palatable food craving after withdrawal using betweensubject assessment. An unexpected finding was a lack of incubation of food craving using the within-subject assessment.…”

Section: Incubation Of Methamphetamine and Food Craving In Unpunishedsupporting

confidence: 91%

“…For comparison purposes, we also assessed incubation of methamphetamine craving under forced abstinence conditions like those typically used in incubation of drug craving studies (Lu et al, 2004b;Pickens et al, 2011). In addition, as incubation of craving has been demonstrated in rats trained to self-administer non-drug rewards (eg, sucrose) (Grimm et al, 2005;Grimm et al, 2002;Lu et al, 2004b), we also tested incubation of reward craving after both forced abstinence and punishment-induced suppression of extended-access palatable food self-administration.…”

Section: Introductionmentioning

confidence: 99%

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Incubation of Methamphetamine and Palatable Food Craving after Punishment-Induced Abstinence

Krasnova

Marchant

Ladenheim

et al. 2014

Neuropsychopharmacol

115

131

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In a rat model of drug craving and relapse, cue-induced drug seeking progressively increases after withdrawal from methamphetamine and other drugs, a phenomenon termed 'incubation of drug craving'. However, current experimental procedures used to study incubation of drug craving do not incorporate negative consequences of drug use, which is a common factor promoting abstinence in humans. Here, we studied whether incubation of methamphetamine craving is observed after suppression of drug seeking by adverse consequences (punishment). We trained rats to self-administer methamphetamine or palatable food for 9 h per day for 14 days; reward delivery was paired with a tone-light cue. Subsequently, for one group within each reward type, 50% of the lever-presses were punished by mild footshock for 9-10 days, whereas for the other group lever-presses were not punished. Shock intensity was gradually increased over time. Next, we assessed cue-induced reward seeking in 1-h extinction sessions on withdrawal days 2 and 21. Response-contingent punishment suppressed extended-access methamphetamine or food self-administration; surprisingly, food-trained rats showed greater resistance to punishment than methamphetamine-trained rats. During the relapse tests, both punished and unpunished methamphetamine-and food-trained rats showed significantly higher cue-induced reward seeking on withdrawal day 21 than on day 2. These results demonstrate that incubation of both methamphetamine and food craving occur after punishment-induced suppression of methamphetamine or palatable food self-administration. Our procedure can be used to investigate mechanisms of relapse to drug and palatable food seeking under conditions that more closely approximate the human condition.

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Section: Incubation Of Methamphetamine and Food Craving In Unpunishedsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Incubation of Methamphetamine and Palatable Food Craving after Punishment-Induced Abstinence

Krasnova

Marchant

Ladenheim

et al. 2014

Neuropsychopharmacol

115

131

View full text Add to dashboard Cite

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“…Cue-induced relapse to reward seeking is one model that has provided insight into the neurobiology of drug seeking (Shalev et al 2002) and most recently insight into food seeking (Grimm et al 2005(Grimm et al , 2006Bossert et al 2005). In this animal model, rats respond for the presentation of a stimulus (tone+light) that was previously associated with self-administration of a reward.…”

Section: Introductionmentioning

confidence: 99%

“…Using this model, we and others have identified and characterized a time-dependent increase in responding for drug and food cues during abstinence from selfadministration Bossert et al 2005 for reviews). In addition to the finding that the "incubation" of craving for sucrose is resistant to manipulations designed to reduce it (e.g., satiation with sucrose; Grimm et al 2005), we have found that rats are less sensitive to the response-potentiating effects of cocaine at 1 month of forced abstinence vs 1 day (Grimm et al 2006). This finding suggests time-dependent changes in the sensitivity of brain reward systems and has led us to consider how such transmitter systems might be affected by, or contribute to, the incubation of sucrose craving.…”

Section: Introductionmentioning

confidence: 99%

Naloxone attenuates incubated sucrose craving in rats

et al. 2007

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Rationale-Cue-induced craving precedes drug relapse and contributes to eating disorders. Opiate antagonists have been demonstrated to be effective at reducing cravings for drugs and food. Craving, as defined as responding for a stimulus previously associated with a reward, increases, or incubates, over forced abstinence in an animal model of relapse.Objectives-This paper aims to determine anticraving effects of the opiate antagonist, naloxone, on the incubation of sucrose craving.Methods-106 male Long-Evans rats lever pressed for 10% sucrose solution 2 h/day for 10 days. On either day 1 or 30 of forced abstinence, rats responded in extinction for 6 h and then were injected (ip) with either saline or naloxone (0.001, 0.01, 0.1, 1, or 10 mg/kg). The rats then responded for 1 h for presentation of a tone+light cue previously presented with every sucrose delivery during selfadministration training.Results-The rats responded more in extinction and following saline on day 30 vs day 1 (an incubation of craving). Except for a trend for a decrease in responding following 10 mg/kg on day 1, naloxone was primarily effective on day 30. On day 30, naloxone significantly reduced responding at all doses except for 0.1 mg/kg. Conclusions-The time-dependent increase in sensitivity to an opiate antagonist is consistent with time-dependent changes in the opiate system following forced abstinence from sucrose. These changes may partly underlie the incubation of sucrose craving. In addition, these findings could be used to support the use of naloxone as an anticraving medication in protracted abstinence.

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“…For example, the acquisition of responding for cocaine-and sucrose-paired conditioned reinforcers is topographically similar, and both are equally persistent (Grimm et al 2001(Grimm et al , 2005Di Ciano and Everitt 2004). Therefore, we have employed an acquisition of a new instrumental response with conditioned reinforcement (ANR) procedure to investigate further the pharmacological mechanisms of appetitive memory reconsolidation, using the ␤-adrenergic receptor antagonist propranolol as a putative amnestic agent, with both natural (sucrose) and drug (cocaine) reinforcers.…”

mentioning

confidence: 99%

Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on β-adrenergic receptors

Milton¹,

Lee²,

Everitt³

2008

Learn. Mem.

153

172

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We have investigated the neurochemical mechanisms of memory reconsolidation and, in particular, the functional requirement for intracellular mechanisms initiated by ␤-adrenergic signaling. We show that propranolol, given in conjunction with a memory reactivation session, can specifically disrupt the conditioned reinforcing properties of a previously appetitively reinforced conditioned stimulus (CS), whether the stimulus had been associated with self-administered cocaine or with sucrose. These data show that memories for both drug and nondrug CS-US associations are dependent on ␤-adrenergic receptor-mediated signaling for their reconsolidation, with implications for the potential development of a novel treatment for drug addiction and some forms of obesity.The neurochemical mechanisms underlying memory reconsolidation-the process hypothesized to occur following the reactivation or retrieval of a fully consolidated memory upon reexposure to conditioned stimuli (Nader 2003; Dudai and Eisenberg 2004)-have become increasingly investigated, in part because of the emergence of the view that disrupting memory reconsolidation might be exploited to treat neuropsychiatric disorders based upon the existence of maladaptive memories (e.g., Debiec and LeDoux 2006).Adrenergic signaling is implicated in both memory consolidation and reconsolidation; the administration of adrenaline enhances memory consolidation in aversive and appetitive tasks in animals and humans (Gold et al. 1977;Liang et al. 1985;Sternberg et al. 1985;Introini-Collison and McGaugh 1986), and the administration of adrenergic receptor antagonists induces memory deficits in tasks including inhibitory avoidance (Lennartz et al. 1996), taste memory (Miranda et al. 2003), and odor-reward associations (Wilson et al. 1994) in rats and, in humans, fear memory (Grillon et al. 2004) and emotional learning (Cahill et al. 1994;van Stegeren et al. 1998). In rodents, ␤-adrenergic signaling has also been implicated in the reconsolidation of CS-fear memories (Debiec and LeDoux 2004), drugassociated memories (Bernardi et al. 2006), spatial memories (Przybyslawski et al. 1999), and other forms of appetitive memory (Diergaarde et al. 2006). However, although the administration of ␤-adrenergic receptor antagonists has been shown to disrupt appetitive memories in both a cocaine-conditioned place preference (Bernardi et al. 2006) and a context-induced sucroseseeking task (Diergaarde et al. 2006), it remains unclear whether CS-food memories undergo reconsolidation in a similar manner to CS-addictive drug associations.It has been proposed that drug-associated memories may be mediated by the same neural and psychological mechanisms as memories resultant on conditioning to natural rewards (Robbins and Everitt 2002;Kelley 2004). For example, the acquisition of responding for cocaine-and sucrose-paired conditioned reinforcers is topographically similar, and both are equally persistent (Grimm et al. 2001(Grimm et al. , 2005Di Ciano and Everitt 2004). Therefore, we have employed an acquis...

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Incubation of sucrose craving: effects of reduced training and sucrose pre-loading

Cited by 117 publications

References 24 publications

Incubation of Methamphetamine and Palatable Food Craving after Punishment-Induced Abstinence

Incubation of Methamphetamine and Palatable Food Craving after Punishment-Induced Abstinence

Naloxone attenuates incubated sucrose craving in rats

Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on β-adrenergic receptors

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