Indanols. II. Aminoalkyl Ethers

Acyl guanidine functional poly(2‐oxazoline)s as reactive intermediates and stimuli‐responsive materials

“…45 Hence, their application as bioisosters of guanidines received attention in medicinal chemistry to increase uptake and improve biodistribution, [45][46][47] thereby improving the efficacy of many guanidine-based drugs. [48][49][50] These interesting features have led us to explore the utilization of methyl ester functional PAOx for the acylation of guanidines. Within this contribution, we show the successful synthesis and isolation of three acyl guanidine adducts, as well as their utility as a reactive moiety for the synthesis of acyl-2-aminoimidazoles, see Scheme 1, [51][52][53] which present a class of pharmacologically active substances.…”