Indapamide in the treatment of hypertension in non-insulin-dependent diabetes.

Abstract

I T is well recognized that hypertensive patients with diabetes have more than double the frequency of heart disease seen in normotensive diabetic patients' and that blood pressure control over long periods of time delays or prevents many vascular complications. 2 In hypertensive nondiabetic patients the reduction of diastolic pressure under 90 mm Hg reduces morbidity and mortality, 3 and there is evidence that the same holds true for hypertensive diabetic persons. It has been shown that early and aggressive treatment of hypertension reduces albuminuria in type I diabetic nephropathy. 4

Evaluation of the efficacy and tolerability of the combination delapril plus indapamide in the treatment of mild to moderate essential hypertension: a randomised, multicentre, controlled study

“…In the Abbou study, 15 indapamide was administered for 4 months, and a significant reduction in blood pressure was observed after 6 weeks of treatment. In another study, 22 performed in diabetic patients, an evident antihypertensive effect was present after only 4 weeks of therapy. In our study, the D+I combination was able to normalise blood pressure in more than 70% of the patients after 1 month, and in more than 90% after 2 months of treatment.…”

Low dose combinations in the treatment of hypertension: theory and practice

“…The non-thiazide diuretic indapamide fulfills the overall criteria for a diuretic to be used in combination with other antihypertensive agents since it effectively lowers the blood pressure and does not compromise serum cholesterol 14 or plasma glucose levels 15 while it also reduces left ventricular hypertrophy (LVH). 16 The formulation of perindopril and idapamide has been shown to provide multiple ancillary benefits in an experimental model of salt-sensitive hypertension.…”

Efficacious Response with Low-Dose Indapamide Therapy in the Treatment of Type II Diabetic Patients with Normal Renal Function or Moderate Renal Insufficiency and Moderate Hypertension

“…Indapamide in a dose of 2.5 mg/day has been shown to be effective in the treatment of moderate hypertension in patients with normal renal function [7], in those with renal failure [1], in elderly patients [8][9][10] and in those with diabetes mellitus [4,5,11].…”

“…There were only small decrements in the serum levels of potassium and a small increment in plasma uric acid concentration. Apart from a few cases where blood glucose levels have risen following indapamide therapy, the overall results of studies of up to 1 year's duration have shown that 2.5 mg indapamide/day does not adversely affect glucose tolerance in diabetic and nondiabetic hypertensive patients [4,5,11,14]. Similarly, this dose of indapamide did not cause a significant increment in total plasma cholesterol, triglycerides or low density and high density lipoproteins [13][14][15].…”

“…Indapamide is an effective drug for the treatment of moderate hypertension, even in patients with chronic renal insufficiency and in those with diabetes mellitus [1][2][3][4][5]. The antihypertensive effect of indapamide is mainly due to its vasorelaxant action but the drug has a mild diuretic effect as well [6].…”