Indentation Versus Tensile Measurements of Young's Modulus for Soft Biological Tissues

McKee, Clayton T.; Russell, Paul; Murphy, Christopher J.

doi:10.1089/ten.teb.2010.0520

Cited by 592 publications

(441 citation statements)

References 155 publications

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“…In the current study, the accuracy of the measurement is limited by the heterogeneous spatial distribution of actual stress and strain under indentation test, as well as the heterogeneous mechanical properties of tissue [30]. In principle, our qOCE technology can be used to study nonlinear elasticity with considerable spatial resolution [20].…”

Section: Discussionmentioning

confidence: 99%

Nonlinear characterization of elasticity using quantitative optical coherence elastography

Qiu

Zaki

Chandra

et al. 2016

Biomed. Opt. Express

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Optical coherence elastography (OCE) has been used to perform mechanical characterization on biological tissue at the microscopic scale. In this work, we used quantitative optical coherence elastography (qOCE), a novel technology we recently developed, to study the nonlinear elastic behavior of biological tissue. The qOCE system had a fiber-optic probe to exert a compressive force to deform tissue under the tip of the probe. Using the space-division multiplexed optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to simultaneously quantify the probe deformation that was proportional to the force applied, and to quantify the tissue deformation. In other words, our qOCE system allowed us to establish the relationship between mechanical stimulus and tissue response to characterize the stiffness of biological tissue. Most biological tissues have nonlinear elastic behavior, and the apparent stress-strain relationship characterized by our qOCE system was nonlinear an extended range of strain, for a tissuemimicking phantom as well as biological tissues. Our experimental results suggested that the quantification of force in OCE was critical for accurate characterization of tissue mechanical properties and the qOCE technique was capable of differentiating biological tissues based on the elasticity of tissue that is generally nonlinear.

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Section: Discussionmentioning

confidence: 99%

Nonlinear characterization of elasticity using quantitative optical coherence elastography

Qiu

Zaki

Chandra

et al. 2016

Biomed. Opt. Express

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“…Thus, until now only limited in vivo and in vitro data is available for dynamic shear moduli of (human) skin (Agache et al, 1980;Escoffier et al, 1989;Geerligs et al, 2011a;Holt et al, 2008); shear moduli ranging from 0.2 to 120 kPa have been reported. Shear moduli are typically 1-3 orders of magnitude lower than moduli derived from uni-axial tensile (1-30 MPa), indentation (85-600 kPa), or suction experiments (100-300 MPa) (Diridollou et al, 2001;Geerligs et al, 2011a;McKee et al, 2011;Sanders, 1971Sanders, , 1973. These results clearly illustrate the complex anisotropical material behaviour of skin and the huge scatter in results; further research is clearly needed to fully elucidate the mechanical properties of skin.…”

Section: 2mentioning

confidence: 92%

A novel method for visualising and quantifying through-plane skin layer deformations

Gerhardt

Schmidt

Sanz-Herrera

et al. 2012

Journal of the Mechanical Behavior of Biomedical Materials

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“…These properties are a function of the material itself, as well as bioprinting process parameters ( Figure 1B). Printed tensile specimens have been used to investigate the interaction of lines and layers [9][10][11][12][13][14][15][16][17], however, a systematic investigation of how process parameters influence these properties has not been conducted. Terminology to describe the tensile measurements include two crucial aspects.…”

Section: Introductionmentioning

confidence: 99%

Guidelines for standardization of bioprinting: a systematic study of process parameters and their effect on bioprinted structures

et al. 2016

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Biofabrication techniques including threedimensional bioprinting could be used one day to fabricate living, patient-specific tissues and organs for use in regenerative medicine. Compared to traditional casting and molding methods, bioprinted structures can be much more complex, containing for example multiple materials and cell types in controlled spatial arrangement, engineered porosity, reinforcement structures and gradients in mechanical properties. With this complexity and increased function, however, comes the necessity to develop guidelines to standardize the bioprinting process, so printed grafts can safely enter the clinics. The bioink material must firstly fulfil requirements for biocompatibility and flow. Secondly, it is important to understand how process parameters affect the final mechanical properties of the printed graft. Using a gellan-alginate physically crosslinked bioink as an example, we show shear thinning and shear recovery properties which allow good printing resolution. Printed tensile specimens were used to systematically assess effect of line spacing, printing direction and crosslinking conditions. This standardized testing allowed direct comparison between this bioink and three commercially-available products. Bioprinting is a promising, yet complex fabrication method whose outcome is sensitive to a range of process parameters. This study provides the foundation for highly needed best practice guidelines for reproducible and safe bioprinted grafts.

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Indentation Versus Tensile Measurements of Young's Modulus for Soft Biological Tissues

Cited by 592 publications

References 155 publications

Nonlinear characterization of elasticity using quantitative optical coherence elastography

Nonlinear characterization of elasticity using quantitative optical coherence elastography

A novel method for visualising and quantifying through-plane skin layer deformations

Guidelines for standardization of bioprinting: a systematic study of process parameters and their effect on bioprinted structures

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