Independent and Additive Effects of Coenzyme Q10 and Vitamin E on Cardiometabolic Outcomes and Visceral Adiposity in Women With Polycystic Ovary Syndrome

Izadi, Azimeh; Shirazi, Shabnam; Taghizadeh, Sepehr; Gargari, Bahram Pourghassem

doi:10.1016/j.arcmed.2019.04.004

Cited by 29 publications

(37 citation statements)

References 52 publications

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“…In the present study, we observed that tempol ameliorated estrous cycles disorders, ovarian morphology disruption, increased serum testosterone levels, and cell apoptosis in DHEA-treated rats, which suggest that tempol could improve ovarian dysfunction in PCOS rats. Our results concurred with other previous studies that demonstrated the beneficial effects of antioxidant supplementation on patients with PCOS [ 10 , 35 ].…”

Section: Discussionsupporting

confidence: 93%

“…A study by Masjedi et al demonstrated a significant reduction in superoxide dismutase (SOD) activity in serum and follicular fluid of patient with PCOS [ 7 ], whereas another study by Sun et al demonstrated the association of glutathione peroxidase 1 (GPx1) P198L genetic polymorphism with PCOS risk in Chinese women [ 8 ]. Because oxidative stress is reflected as an imbalance between pro- and antioxidants, several antioxidants, such as vitamin C [ 9 ], vitamin E [ 10 , 11 ] and MitoQ10 [ 12 ] have been recognized as potential therapeutics for PCOS. A recent cohort study exhibited that, a short-term supplementation of vitamin E in patients with PCOS can reduce oxidative stress, and reduce exogenous human menopausal gonadotropin dosage in the ovulation induction cycle [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction

Zhang

Gao

et al. 2021

Redox Biology

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Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, which is often accompanied by oxidative stress. Tempol, a superoxide dismutase mimetic, protects against several diseases caused by oxidative stress. However, the effect of tempol on PCOS has not been investigated. The present study demonstrated the alleviation of ovarian dysfunction and glucose tolerance in dehydroepiandrosterone (DHEA)-induced PCOS rats treated with tempol. Tempol significantly reduced the intestinal oxidative stress in PCOS rats without affecting the ovarian redox rate. The 16S rDNA sequencing of the intestinal microbiome and non-targeted metabolomics analysis indicated significant differences in gut microbiota composition and serum metabolite profiles between the control and PCOS rats, and most of these differences were reduced after tempol intervention. Tempol alters the gut microbiome by increasing the abundance of genus Ruminococcus_1 and by decreasing the abundance of Ruminococcus_2 , Staphylococcus , Ideonella, and Corynebnacterium genera. Tempol also attenuates the reduction of serum bile acid and stachyose levels in PCOS rats, and the serum stachyose level was significantly correlated with the abundance of 15 genera, particularly Ruminococcus_1 and Ruminococcus_2 . Moreover, stachyose administration improved ovarian dysfunction in PCOS rats. Thus, our data indicate that tempol ameliorates PCOS phenotype by reducing intestinal oxidative stress, restoring gut dysbiosis, and modulating the interaction between gut microbiota and host metabolite. Therefore, tempol intervention is a potential therapeutic approach for PCOS.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction

Zhang

Gao

et al. 2021

Redox Biology

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“…Moreover, it is noteworthy that CoQ 10 in coadministration with alfa-tocopherol presented a more pronunced effect and stimulated the release of sex hormone-binding globulin (SHBG), justifing the enhancement of insulin tolerance, since an insulin resistance condition is associated with a reduced synthesis of SHBG at the hepatic level. Then, CoQ 10 might promote steroid hormone biosynthesis and normal reproductive function (among which are oocyte maturation, fertilization, and embryonic development) through the improvement of mitochondrial functionality [59]. However, new, larger RCTs are needed to confirm the results obatined by Izadi et al…”

Section: Insulin-resistance and Type 2 Diabetesmentioning

confidence: 97%

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

et al. 2020

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Coenzyme Q10 (CoQ10) is a ubiquitous factor present in cell membranes and mitochondria, both in its reduced (ubiquinol) and oxidized (ubiquinone) forms. Its levels are high in organs with high metabolism such as the heart, kidneys, and liver because it acts as an energy transfer molecule but could be reduced by aging, genetic factors, drugs (e.g., statins), cardiovascular (CV) diseases, degenerative muscle disorders, and neurodegenerative diseases. As CoQ10 is endowed with significant antioxidant and anti-inflammatory features, useful to prevent free radical-induced damage and inflammatory signaling pathway activation, its depletion results in exacerbation of inflammatory processes. Therefore, exogenous CoQ10 supplementation might be useful as an adjuvant in the treatment of cardiovascular diseases such as heart failure, atrial fibrillation, and myocardial infarction and in associated risk factors such as hypertension, insulin resistance, dyslipidemias, and obesity. This review aims to summarize the current evidences on the use of CoQ10 supplementation as a therapeutic approach in cardiovascular diseases through the analysis of its clinical impact on patients’ health and quality of life. A substantial reduction of inflammatory and oxidative stress markers has been observed in several randomized clinical trials (RCTs) focused on several of the abovementioned diseases, even if more RCTs, involving a larger number of patients, will be necessary to strengthen these interesting findings.

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“…The combined treatment of magnesium and vitamin E for PCOS for 12 weeks has benefits for hirsutism, serum hs-CRP, plasma NO, and TAC levels [ 97 ]. Extensive research papers have proven that the treatment of vitamin E in patients with PCOS has a significant effect [ 98 , 99 ]. It can significantly reduce TG and serum total cholesterol and improve IR, T, and free testosterone index in patients with PCOS.…”

Section: Dietary Supplementsmentioning

confidence: 99%

The Complementary and Alternative Medicine for Polycystic Ovary Syndrome: A Review of Clinical Application and Mechanism

Jia

Feng

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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As a reproductive endocrine disease, polycystic ovary syndrome (PCOS) has influenced billions of women during childbearing age worldwide. Owing to its complex etiology and ambiguous pathogenesis, there is still not a specific method to cure it. Clinical treatments, such as hormone therapy and surgical treatment, have side effects. Therefore, it is essential and urgent to seek alternative treatment to solve these problems. The satisfactory efficacy of complementary and alternative medicine (CAM), such as traditional Chinese medicine (TCM), immunotherapy, medicinal foods, vitamin therapy, diet therapy, psychotherapy, spa, and oxygen therapy, in treating PCOS, has aroused an increasing number of medical workers’ concern and gradually become the mainstream. This paper reviews the application of CAM in the treatment of PCOS, especially from the perspective of TCM. Meanwhile, the limitations of the literature about CAM in the treatment of PCOS are mentioned and analyzed as well.

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Independent and Additive Effects of Coenzyme Q10 and Vitamin E on Cardiometabolic Outcomes and Visceral Adiposity in Women With Polycystic Ovary Syndrome

Cited by 29 publications

References 52 publications

Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction

Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

The Complementary and Alternative Medicine for Polycystic Ovary Syndrome: A Review of Clinical Application and Mechanism

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