Independent and joint association of physical activity and adequate weekday sleep duration with metabolic dysfunction-associated steatotic liver disease

Li, Yaxin; Guo, Yitian; Tan, Shiyun

doi:10.1016/j.clinre.2024.102320

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…A study based on the 2017–2018 U.S. population shows that physical activity is strongly associated with a lower risk of obese and non-obese MAFLD ( 88 ). Active physical activity PA and adequate weekday sleep duration are both inversely associated with the risk of MASLD, and combining them can further reduce the risk of MASLD ( 89 ). Increased physical activity improves the strength of the muscles in the body.…”

Section: Lifestyle Interventions Of Mafldmentioning

confidence: 99%

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Chen,

Qin,

Jiang

et al. 2024

Front. Nutr.

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MAFLD has become a major global health problem and is the leading cause of liver disease worldwide. The disease progresses from a simple fatty liver to gradual fibrosis, which progresses to cirrhosis and even hepatocellular liver cancer. However, the methods currently used for diagnosis are invasive and do not facilitate clinical assessment of the condition. As a result, research on markers for the diagnosis of MAFLD is increasing. In addition, there are no clinical medications for the treatment of MAFLD, and lifestyle interventions remain effective in the prevention and treatment of MAFLD. In this review, we attempt to make a summary of the emerging diagnostic indicators and effective lifestyle interventions for MAFLD and to provide new insights into the diagnosis and treatment of MAFLD.

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Section: Lifestyle Interventions Of Mafldmentioning

confidence: 99%

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Chen,

Qin,

Jiang

et al. 2024

Front. Nutr.

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Letter to the Editor: Association between physical activity and diet quality of obese and non-obese MAFLD

Kakar,

Fatima,

Samiullah

2024

Nutrition, Metabolism and Cardiovascular Diseases

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Life’s essential 8 and mortality in US adults with metabolic dysfunction-associated steatotic liver disease

Zhang,

Wang,

et al. 2024

BMC Public Health

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Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to increased all-cause mortality due to metabolic dysfunctions like obesity, diabetes, and cardiovascular diseases. This study examines the association between Life’s Essential 8 (LE8) scores and both all-cause and cardiovascular disease (CVD) mortality in MASLD participants. Methods Data from 5,916 MASLD participants in the NHANES (2005–2018) were analyzed. Associations between LE8 scores and all-cause and CVD mortality were assessed using Cox proportional hazards models, with follow-up until December 31, 2019. Dose-response relationships and survival differences were evaluated using Kaplan-Meier survival curves and Restricted Cubic Spline models. Results Over a median follow-up of 7.6 years, moderate and high LE8 scores were associated with 33% (HR: 0.67; 95% CI: 0.56–0.79) and 47% (HR: 0.53; 95% CI: 0.33–0.84) lower risk of all-cause mortality, respectively, compared to low scores. For CVD mortality, the adjusted HRs were 0.56 (95% CI: 0.41–0.78) and 0.35 (95% CI: 0.12-1.0). Higher LE8 scores were significantly associated with reduced cumulative incidence of all-cause and CVD mortality (log-rank P < 0.001). A 10-point increase in health behavior scores, particularly in diet, physical activity, and nicotine exposure, was linked to an 11% reduction in all-cause mortality risk and an 11% reduction in CVD mortality risk. Among health factors, only blood glucose showed a significant association with CVD mortality. Conclusion Higher LE8 scores in MASLD patients are associated with lower mortality risk, suggesting the potential value of promoting cardiovascular health in this population. Further research is needed to confirm these associations. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1186/s12889-024-20919-6.

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Independent and joint association of physical activity and adequate weekday sleep duration with metabolic dysfunction-associated steatotic liver disease

Cited by 3 publications

References 38 publications

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Letter to the Editor: Association between physical activity and diet quality of obese and non-obese MAFLD

Life’s essential 8 and mortality in US adults with metabolic dysfunction-associated steatotic liver disease

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