Independent and joint associations of general and abdominal obesity with the risk of conventional adenomas and serrated polyps: A large population‐based study in East Asia

Bai, Hao; Xu, Zenghao; Li, Jiayu; Zhang, Xiaocong; Gao, Kai; Fei, Xinglin; Yang, Jing; Li, Qilong; Qian, Sangni; Zhang, Wanting; Gao, Xichao; Tang, Mengling; Wang, Jianbing; Chen, Kun; Jin, Mingjuan

doi:10.1002/ijc.34503

Cited by 6 publications

(5 citation statements)

References 47 publications

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“…In addition to general obesity assessed by BMI, we may need to pay more attention to abdominal obesity assessed by waist circle conference or waist to hip ratio in future studies. 36,37 In addition, lifestyle factors 38 (Western diet, 39 alcohol, 40 tobacco, 41 prolonged sedentary TV viewing, 42 etc.) are risk factors for EOCRC or ACN.…”

Section: Discussionmentioning

confidence: 99%

“…The inconsistencies in the BMI results may be attributed to the inconsistent composition of BMI categories across different screening protocols, and the predominantly cross‐sectional nature of the studies, which only observe BMI at the time of screening and lack longitudinal follow‐up. In addition to general obesity assessed by BMI, we may need to pay more attention to abdominal obesity assessed by waist circle conference or waist to hip ratio in future studies 36,37 …”

Section: Discussionmentioning

confidence: 99%

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Prevalence and risk factors of colorectal neoplasia in individuals aged 40–49 years: Findings from screening program in China

Zhang,

Zhang

et al. 2024

J of Gastro and Hepatol

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Background and AimThe incidence of colorectal cancer (CRC) in individuals under 50 is increasing worldwide. We conducted an analysis of colonoscopy findings in high‐risk individuals under 50 in the CRC screening program in Tianjin, China, to determine the detection rate and risk factors of advanced adenomas (AA), advanced colorectal neoplasia (ACN), colorectal neoplasia (CN).MethodsOur study investigated individuals aged 40–49 who underwent CRC screening and completed colonoscopy, 2012–2020, while the 50–54 age group served as a control. We compared the detection rates of AA, ACN, and CN among three age groups using univariate and multivariable logistic regression analyses, and investigated the risk factors associated with AA, ACN, and CN among individuals aged 40–49.ResultsWe found a gradual increase in the detection rate of AA, ACN, and CN among individuals aged 40–54. The detection rates for AA (OR 0.58; 95% CI 0.41–0.81), ACN (OR 0.58; 95% CI 0.43–0.77), and CN (OR 0.64; 95% CI 0.56–0.74) were lower in individuals aged 40–44 compared to 45–49. The detection rates of AA (OR 1.08; 95% CI 0.87–1.34) and ACN (OR 1.12; 95% CI 0.93–1.35) in individuals aged 45–49 were comparable with 50–54. Besides, lifestyle factors, BMI, and FIT are not associated with the detection rates of AA, ACN, and CN among individuals aged 40–49.ConclusionsOur study reveals screening data in individuals under 50, indicating comparable detection rates of AA and ACN in individuals aged 45–49 and 50–54. These findings provide valuable data support for optimizing the optimal age to initiate screening.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prevalence and risk factors of colorectal neoplasia in individuals aged 40–49 years: Findings from screening program in China

Zhang,

Zhang

et al. 2024

J of Gastro and Hepatol

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“…Bai et al demonstrated an association between WHR and conventional adenomas or serrated polyps. 39 Another study has indicated that men with a higher BMI and WHR are associated with an increased risk of hyperplastic polyps, adenomas, and the occurrence of both types of polyps. 40 The prevalence of colorectal diverticula was higher in overweight people, so the chance of the development of polyps increased with increasing BMI.…”

Section: Discussionmentioning

confidence: 99%

The Association between Anthropometric Indicators and Colorectal Polyps and Diverticulosis

Najafi Mobaraki,

Joukar,

Maroufizadeh

et al. 2024

Journal of Coloproctology

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Introduction Colonic polyps and diverticulosis are common colon findings on colonoscopy. One of the risk factors of colorectal polyps and diverticulosis is the anthropometric index. Therefore, we aimed to investigate the association between the anthropometric index and colorectal findings. Methods In this cross-sectional study, we included 536 patients referred to Razi Hospital, Rasht, Iran, in 2023 for colonoscopy evaluation. Demographical data, clinical characteristics, and colonoscopy findings were recorded for further analysis. All data were analyzed using SPSS.16 by considering a significant level < 0.05 Results The results showed that 35.4% of the patients had polyps, with the majority having a single polyp. The patient's mean age was 55.94 ± 13.33 years; most were females (54.1%). The most common type of polyp was pedunculated, and most were located in the sigmoid colon. The prevalence of diverticular was 11.4%, most of which were also located in the sigmoid colon. Obesity was significantly associated with an increased risk of polyps, while overweight individuals had a higher risk of diverticula (P < 0.05). Age, rural residence, and low physical activity level were identified as factors associated with an increased risk of polyps and diverticula. Conclusion The findings suggest that obesity and overweight are risk factors for polyps and diverticula, respectively. Further research is warranted to explore additional factors and develop preventive strategies for colorectal diseases. These results support the need for preventive strategies and screening programs to reduce the risk of future colorectal lesions.

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“…Their gender-specific stratified analysis further suggested a more substantial positive association between SMD adherence and obesity risk in males compared to females ( 51 ). Considering that obesity is a significant risk factor for colorectal cancer and adenoma ( 52 , 53 ), the variation in the association between obesity and adherence to the SMD pattern across genders may be the reason why the association between SMD and colorectal adenoma risk is more significant in males.…”

Section: Discussionmentioning

confidence: 99%

“…Hazard ratios was adjusted for age, sex, race, education levels, smoking status, pack-years of smoking, BMI, aspirin use, history of hypertension, history of diabetes, family history of colorectal cancer, total energy intake, history of diverticulitis or diverticulosis, history of colonoscopy in past 3 years, and physical activity level. cancer and adenoma (52,53), the variation in the association between obesity and adherence to the SMD pattern across genders may be the reason why the association between SMD and colorectal adenoma risk is more significant in males.…”

Section: Discussionmentioning

confidence: 99%

Association between sulfur microbial diet and the risk of colorectal cancer precursors in older adults

Ling

et al. 2023

Front. Nutr.

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BackgroundSulfur microbial diet (SMD), related to the enrichment of sulfur-metabolizing gut bacteria, has been confirmed to be linked to an elevated risk of early-onset colorectal adenoma in young females. However, it remains unclear whether SMD is associated with the risk of colorectal adenoma in older people, who are at greater risk for colorectal cancer.MethodsAll data on participants in this study were retrieved from the intervention arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening test. Participants’ adherence to this dietary pattern was assessed using SMD score. Hazard ratios (HR) and 95% confidence intervals (CI) were adopted in Cox proportional hazards regression models to assess the link between SMD score and the incidence of colorectal adenoma in participants included in the study. Specific stratified analyses were constructed to assess whether this association changed in different conditions, whereas the robustness of the association was examined through sensitivity analyses.ResultsThe mean baseline age of participants was 62.1 (SD 5.2) years (range 54.0–75.0 years). During 19,468,589 person-years of follow-up, 992 colorectal adenoma cases were documented in a total of 17,627 included participants. In a fully adjusted model, an increased risk of colorectal adenoma was determined in participants in the highest quartile of SMD score in comparison with those in the lowest quartile (HRquartile4 vs. HRquartile1 = 1.23; 95% CI: 1.02, 1.47; p = 0.017 for trend). This positive association between SMD score and adenoma risk was more evident in participants who were current or former smokers (p = 0.029 for interaction).ConclusionIn this study, our results support a role for the SMD in the carcinogenicity of colorectal cancer precursors among older adults. Nevertheless, these results require validation through more research.

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Independent and joint associations of general and abdominal obesity with the risk of conventional adenomas and serrated polyps: A large population‐based study in East Asia

Cited by 6 publications

References 47 publications

Prevalence and risk factors of colorectal neoplasia in individuals aged 40–49 years: Findings from screening program in China

Prevalence and risk factors of colorectal neoplasia in individuals aged 40–49 years: Findings from screening program in China

The Association between Anthropometric Indicators and Colorectal Polyps and Diverticulosis

Association between sulfur microbial diet and the risk of colorectal cancer precursors in older adults

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