Independent and Synergistic Modulations of Viscoelasticity and Stiffness of Dynamically Cross-Linked Cell-Encapsulating ClickGels by Covalently Tethered Polymer Brushes

Tan, Yu; Song, Jie

doi:10.1021/acs.biomac.1c00477

Cited by 3 publications

(6 citation statements)

References 45 publications

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“…Although several researches on regulating matrix viscoelasticity have been reported, these methods usually require complex physical crosslinking methods and chemical treatments [99,[106][107][108], and they merely focused on improving the viscoelastic properties of the material itself to achieve a high level of bone regeneration. Future directions need to focus on the new possibilities of combining with strategies that facilitate bone regeneration, such as stem-cell spheroids [29,30], the addition of natural ECM [109], etc.…”

Section: Viscoelasticitymentioning

confidence: 99%

“…The elastic properties determine its elasticity as well as the initial resistance to applied forces 5 . Nonetheless, biomaterials with elasticity solely restrict cell adhesion, proliferation, diffusion and differentiation to a large extent because of their inability to relax forces effectively 98 , 99 . In contrast, the viscous properties dissipate the applied load and lead to extinction of drag force as well as permanent deformation over time.…”

Section: Biomaterials-induced Physicomechanical Stimuli Towards Mscsmentioning

confidence: 99%

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Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs

Shi¹,

Zhou²,

Wang³

et al. 2023

Theranostics

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Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the most promising alternative to avoid the drawbacks of autograft and allograft bone. Nevertheless, how to precisely control stem cell osteogenic differentiation has been a long-standing puzzle. Compared with biochemical cues, physicomechanical stimuli have been widely studied for their biosafety and stability. The mechanical properties of various biomaterials (polymers, bioceramics, metal and alloys) become the main source of physicomechanical stimuli. By altering the stiffness, viscoelasticity, and topography of materials, mechanical stimuli with different strengths transmit into precise signals that mediate osteogenic differentiation. In addition, externally mechanical forces also play a critical role in promoting osteogenesis, such as compression stress, tensile stress, fluid shear stress and vibration, etc. When exposed to mechanical forces, mesenchymal stem cells (MSCs) differentiate into osteogenic lineages by sensing mechanical stimuli through mechanical sensors, including integrin and focal adhesions (FAs), cytoskeleton, primary cilium, ions channels, gap junction, and activating osteogenic-related mechanotransduction pathways, such as yes associated proteins (YAP)/TAZ, MAPK, Rho-GTPases, Wnt/β-catenin, TGFβ superfamily, Notch signaling. This review summarizes various biomaterials that transmit mechanical signals, physicomechanical stimuli that directly regulate MSCs differentiation, and the mechanical transduction mechanisms of MSCs. This review provides a deep and broad understanding of mechanical transduction mechanisms and discusses the challenges that remained in clinical translocation as well as the outlook for the future improvements.

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Section: Viscoelasticitymentioning

confidence: 99%

Section: Biomaterials-induced Physicomechanical Stimuli Towards Mscsmentioning

confidence: 99%

Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs

Shi¹,

Zhou²,

Wang³

et al. 2023

Theranostics

View full text Add to dashboard Cite

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Section: Hydrogel Modified By Internal Polymer Brushesmentioning

confidence: 99%

“…88,92,114 Tan et al integrated nonionic, zwitterionic, or anionic polymer brushes into ClickGels, which were formed by SPAAC covalent cross-linking and DBCO−DBCO physical cross-linking via the SPAAC reaction (Figure 4a). 128 The degree of SPAAC covalent cross-linking, DBCO−DBCO physical cross-linking, and incorporated polymer brushes was precisely designed to modify the properties of the hydrogels (Figures 4b and 4c). It was highlighted that the charge properties of polymer brushes could regulate the elasticity and viscoelasticity of synthetic hydrogels.…”

Section: Spaacmentioning

confidence: 99%

Brush-Modified Hydrogels: Preparations, Properties, and Applications

Feng

Liao

et al. 2022

Chem. Mater.

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The rational design of hydrogels with unique properties has unlocked their valuable and underlying capabilities for various applications in biomedicine, materials science, and chemical engineering. Whereas numerous hydrogels of different structures have been extensively reported in the last few decades, the number of hydrogels with polymer brush architectures is rapidly growing in recent years and they exhibit improved properties, compared with classical hydrogels, including excellent mechanical properties, biocompatibility, stimulus response, antifouling properties, lubrication properties, and other properties. Consequently, brush-modified hydrogels are increasingly being employed in various fields, including biomedical devices, tissue engineering, drug delivery, antifouling materials, and lubrication materials. This review is aimed at providing an overview of the preparations, properties, and applications of brush-modified hydrogels. In this Review, we will start with the introduction of polymer brush-modified hydrogels. After the introduction, we will summarize the research progress of brush-modified hydrogels with internal polymer molecular brushes, followed by brush-modified hydrogels with surface polymer molecular brushes. Finally, summary and outlook of brush-modified hydrogels are discussed.

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“…Hence, matrix viscoelasticity seems to govern essential cellular processes and can foster types of behaviors not evident in cells that are cultured in purely elastic hydrogels in both two- and three-dimensional culture surroundings ( Charbonier et al, 2021 ). Matrix viscoelasticity seems to be important in revealing the complex interplay between cells and their environment at cell-matrix interaction sites and how these interactions variably impact mechanosensitive molecular signaling paths in cells ( Tan and Song, 2021 ). Specifically, the collagen density can foster the progression of cancer ( Provenzano et al, 2008 ).…”

Section: Environmental Matrix Viscoelasticity Acts On Cellsmentioning

confidence: 99%

Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics

Mierke

2021

Front. Cell Dev. Biol.

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Biological materials such as extracellular matrix scaffolds, cancer cells, and tissues are often assumed to respond elastically for simplicity; the viscoelastic response is quite commonly ignored. Extracellular matrix mechanics including the viscoelasticity has turned out to be a key feature of cellular behavior and the entire shape and function of healthy and diseased tissues, such as cancer. The interference of cells with their local microenvironment and the interaction among different cell types relies both on the mechanical phenotype of each involved element. However, there is still not yet clearly understood how viscoelasticity alters the functional phenotype of the tumor extracellular matrix environment. Especially the biophysical technologies are still under ongoing improvement and further development. In addition, the effect of matrix mechanics in the progression of cancer is the subject of discussion. Hence, the topic of this review is especially attractive to collect the existing endeavors to characterize the viscoelastic features of tumor extracellular matrices and to briefly highlight the present frontiers in cancer progression and escape of cancers from therapy. Finally, this review article illustrates the importance of the tumor extracellular matrix mechano-phenotype, including the phenomenon viscoelasticity in identifying, characterizing, and treating specific cancer types.

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Independent and Synergistic Modulations of Viscoelasticity and Stiffness of Dynamically Cross-Linked Cell-Encapsulating ClickGels by Covalently Tethered Polymer Brushes

Cited by 3 publications

References 45 publications

Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs

Integrating physicomechanical and biological strategies for BTE: biomaterials-induced osteogenic differentiation of MSCs

Brush-Modified Hydrogels: Preparations, Properties, and Applications

Viscoelasticity Acts as a Marker for Tumor Extracellular Matrix Characteristics

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