Independent Association Between Nonalcoholic Fatty Liver Disease and Nephrolithiasis

Nonalcoholic Fatty Liver Disease and Urolithiasis. A Systematic Review and Meta-Analysis

“…Two conference abstracts were identified from searching of conference abstract databases. Finally 8 studies [9,[13][14][15][16][17][18][19] with 238,400 participants were included in the meta-analysis. The literature retrieval, review and selection process are shown in Fig.…”

“…To further explore the high heterogeneity of this metaanalysis, a sensitivity analysis was performed by excluding the studies that did not adjust their effect estimates for comorbidities (i.e., excluding studies that did not adjust their results at all and studies that adjusted their results for only age and sex). A total of four studies [14,[17][18][19] remained in this sensitivity analysis and the new pooled OR decreased slightly to 1.21 (remained statistically significant with 95% CI of 1.00 -1.45). Between-study statistical heterogeneity decreased to low level with I 2 of 28%.…”

“…Recent studies have suggested that NAFLD could also be a risk factor for urolithiasis although the results varied considerably across the studies [9,[13][14][15][16][17][18][19]. The current systematic review and meta-analysis was conducted with the aims to identify all studies that compared the risk of urolithiasis among patients with NAFLD versus individuals without NAFLD and to summarize the results of those studies together.…”