Independent association between subjective cognitive decline and frailty in the elderly

Hsieh, Tsung-Jen; Chang, Hsing-Yi; Wu, I-Chien; Chen, Chu-Chih; Tsai, Hui‐Ju; Chiu, Yen‐Feng; Chuang, Shu‐Chun; Hsiung, Chao A.; Hsu, Chih‐Cheng

doi:10.1371/journal.pone.0201351

Cited by 41 publications

(38 citation statements)

References 53 publications

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“…Although the present study did not demonstrate the significant contribution of poor cognitive function towards frailty, higher mean scores of cognitive impairment are observed in pre-frail and frail older adults. This study confirmed previous findings where frail elderly have a higher rate of cognitive impairment than those who are pre-frail and robust [37,38]. Cognitive impairment has been reported to occur concurrently with frailty, as well as to precede frailty [39].…”

Section: Discussionsupporting

confidence: 91%

Physical Frailty among Urban-Living Community-Dwelling Older Adults in Malaysia

Norazman

Adznam

Jamaluddin

2020

IJERPH

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Frailty is a multidimensional syndrome, which is a worldwide concern within the field of geriatrics due to the aggravating effect on the physical and mental functions of the elderly. This study aimed to determine the prevalence and risk factors of the frailty syndrome among urban-living community-dwelling elderly in Malaysia. A cross-sectional study was conducted among 301 community-dwelling elders. Frailty status was assessed using the Fried phenotype criteria. Depressive symptoms were assessed using the Geriatric Depression Scale (M-GDS-14), whereas the functional abilities and cognitive status were measured using the Lawton Instrumental Activities of Daily Living (Lawton IADL) scale and the Mini-Mental State Examination (MMSE-M), respectively. Malnutrition risk was observed through the abridged version (Short Form) of the Mini Nutritional Assessment (MNA-SF). Multinomial logistic regression analysis was employed to determine the significant predictors of the frailty syndrome. Three hundred and one elderly persons engaged in this study, with a mean age of 67.08 ± 5.536 ranging between 60 to 84 years old. The prevalence values of frailty and pre-frail were 15.9% and 72.8%, respectively, in which women appeared to be at a higher risk of frailty. The multivariate model revealed that frailty could be predicted from an increase in age, lower household income, being at risk of malnutrition, wasting (low skeletal muscle mass), and high serum C-reactive protein (CRP) level. A holistic approach is suggested for managing the frailty syndrome as it involves a decline in the multiple components of the geriatric syndrome.

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Section: Discussionsupporting

confidence: 91%

Physical Frailty among Urban-Living Community-Dwelling Older Adults in Malaysia

Norazman

Adznam

Jamaluddin

2020

IJERPH

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“…15 Patients with advanced age are more likely to suffered from cognitive decline, depression, more comorbidities and poor motor activity. [16][17][18] These can lead to the delayed recovery in elderly patients, especially those who are frail, unable to ambulate and feed early. Moreover, elderly patients commonly experienced issues of decreased ability to perform daily activities and difficulty with self-care, which leads to reluctance to discharge, even if the criteria are met.…”

Section: Discussionmentioning

confidence: 99%

Impact of Compliance with an Enhanced Recovery After Surgery Program on the Outcomes Among Elderly Patients Undergoing Lumbar Fusion Surgery

Li¹,

Lu²,

Kong³

et al. 2020

CIA

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Background and Aim The benefits of the enhanced recovery after surgery (ERAS) program to elderly patients have not been evaluated in lumbar fusion surgery. Compliance with the ERAS program is associated with prognosis. There is currently no adequate assessment about the importance of the individual components of ERAS program in lumbar fusion surgery. The aim of the study was to analyze the effect of compliance with our ERAS program and the relative importance of the individual ERAS program components among elderly patients undergoing lumbar fusion surgery. Methods A retrospective case-review study was conducted from March 2018 to March 2020. The ERAS program for lumbar fusion surgery at our department was implemented. Overall compliance was found to be 92.9%, and this was used as a cutoff for dividing patients into higher compliance and lower compliance groups. Patient characteristics and clinical outcomes were compared between groups. Results The overall compliance rate was 92.9%, distributing 91 patients into the higher compliance group and 169 patients into the lower compliance group. Patients with higher compliance were younger (p=0.045). The length of stay (LOS) of patients with higher compliance was significantly shorter than that of patients with lower compliance. Patients with higher compliance had significantly fewer complications (p=0.031). A multivariate analysis showed that surgical time (p=0.029), lower compliance (p=0.034), and early oral feeding (p=0.026) were predictors of any postoperative complications. On multivariate analysis, the following items remained correlated with prolonged LOS (LOS≥12 days): older age (p=0.010), lower compliance (p<0.0001), early ambulation (p=0.018), and stick to discharge criteria (p=0.040). Conclusion Low compliance with ERAS program among elderly patients undergoing lumbar fusion surgery was associated with a higher incidence of complications and prolonged LOS. The failure of early oral feeding was associated with increased complications, and the failure of early ambulation or sticking to discharge criteria was significantly more influential on prolonged LOS.

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“…Se ha descrito que el estado proinflamatorio en adultos mayores aumenta 4,06 veces la probabilidad de presentar fragilidad en el seguimiento a un año (22). En el proceso inflamatorio compartido por la fragilidad y el deterioro cognitivo se encuentran cantidades elevadas de interleucina 8 (IL-8), interleucina 6 (IL-6), proteína C reactiva (PCR) y TNF-alfa.…”

Section: Estrés Oxidativo E Inflamaciónunclassified

Fragilidad cognitiva, un desafío en evolución

et al. 2019

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Dentro de los principales desafíos relacionados con el envejecimiento se encuentran la fragilidad y el deterioro cognitivo, condiciones que se han relacionado con aumento en la declinación funcional, la discapacidad y el deterioro en la calidad de vida. Durante los últimos años se ha demostrado la relación bidireccional entre estas dos condiciones clínicas y dentro del Grupo de Consenso Internacional en Toulouse, Francia, surgió el término fragilidad cognitiva, en el 2013. Ese estado reversible se ha considerado un nuevo síndrome geriátrico, caracterizado por la coexistencia entre fragilidad física y deterioro cognitivo; sin embargo, aún sin criterios diagnósticos definidos. El objetivo es realizar una aproximación de la definición, fisiopatología, herramientas diagnósticas y su respectiva asociación con desenlaces adversos, para realizar un diagnóstico oportuno y aplicar intervenciones multidominio centradas en la actividad física, el enfoque nutricional y el entrenamiento cognitivo, que puedan modificar el curso de este estado dinámico y reversible, previniendo el deterioro funcional y mejorando la calidad de vida de las personas mayores.

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Independent association between subjective cognitive decline and frailty in the elderly

Cited by 41 publications

References 53 publications

Physical Frailty among Urban-Living Community-Dwelling Older Adults in Malaysia

Physical Frailty among Urban-Living Community-Dwelling Older Adults in Malaysia

Impact of Compliance with an Enhanced Recovery After Surgery Program on the Outcomes Among Elderly Patients Undergoing Lumbar Fusion Surgery

Fragilidad cognitiva, un desafío en evolución

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