Independent Association of Lipoprotein(a) and Coronary Artery Calcification With Atherosclerotic Cardiovascular Risk

Elevated lipoprotein(a) as a predictor for coronary events in older men

“…Whilst absolute cutoffs may be beneficial for decision making within the clinic, a linear increase in atherosclerotic CVD risk has been observed with Lp(a) concentration, suggesting that even a modest increase in Lp(a) may be determinantal ( 23 ). Notably, within this study, the observation that no difference was found between low (<30 mg/dl) and elevated (30–50 mg/dl) Lp(a) in ACS risk differs from recent findings, where Lp(a) levels over 30 mg/dl contributed to an increased risk of coronary heart disease ( 44 ) and a linear relationship with both fatal and nonfatal cardiovascular risk ( 45 , 46 ). This may, in part, be due to the disparity in race between the two studies.…”

Correlations Between Coronary Artery Disease, Coronary Artery Calcium Score, and Lipoprotein(a) Level in Korea

“…12 In a recent large-scale study targeting multi-ethnic participants, Lp(a) was related to CAD independently of CAC score. 13 However, other studies suggest that the relationship between Lp(a) and CAD may appear differently depending on age, sex, race, and comorbidities. 7,[14][15][16] The results of our study showed no strong relationship between Lp(a) and CAD in a Korean cohort, and this finding can be explained by the results of previous studies.…”

“…In a community-based study, sex-specific associations between Lp(a) and coronary artery calcium (CAC) score were supported, 12 and another study reported that Lp(a) was strongly associated with high CAC score in women with type 2 diabetes mellitus (DM). 13 Meanwhile, some studies reported negative results. 10 , 14 …”

“…In a community-based study, sex-specific associations between Lp(a) and coronary artery calcium (CAC) score were supported, 12 and another study reported that Lp(a) was strongly associated with high CAC score in women with type 2 diabetes mellitus (DM). 13 Meanwhile, some studies reported negative results. 10,14 The purpose of this study was to determine the correlation between Lp(a) level and CAC score in Korean patients, and to determine the relationship between Lp(a) and CAD.…”

Lp(a): a New Pathway to Target?

“…Absolute cut-off values should be cautiously interpreted, since plasma levels of Lp(a) are highly dependent upon ethnicity [ 2 ]. In a recent analysis by Mehta et al in the MESA (Multi-Ethnic Study of Atherosclerosis), black participants had a median Lp(a) level of 35.2 mg/dl, much higher than white, Hispanic, or Chinese participants (median 13.2 mg/dl) [ 3 ]. Despite the racial differences, the ASCVD risk resulting from Lp(a) seems largely similar across different ethnicities [ 2 ].…”