Independent co-delivery of model actives with different degrees of hydrophilicity from oil-in-water and water-in-oil emulsions stabilised by solid lipid particles via a Pickering mechanism: a-proof-of-principle study

Sakellari, Georgia I.; Zafeiri, Ioanna; Pawlik, Aleksandra K.; Kurukji, Daniel; Taylor, Philip; Norton, Ian T.; Spyropoulos, Fotis

doi:10.1016/j.jcis.2020.11.021

Cited by 21 publications

(9 citation statements)

References 41 publications

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“…In general, both lipid nanocarriers can be used to deliver poorly water-soluble drugs and bioactive molecules [23]. Next, due to their inherent tuneable microstructure, they are also utilized as emulsion stabilizers [24].…”

Section: Organic Nanoparticlesmentioning

confidence: 99%

Advances in cosmeceutical nanotechnology for hyperpigmentation treatment

2022

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Hyperpigmentation is a common and major skin problem that affects people of all skin types. Despite the availability of various depigmentation active ingredients for skin hyperpigmentation disorder, none of them are completely satisfactory due to their poor permeability through the skin layer and significant toxicity, thereby causing severe side effects such as irritative dermatitis, erythema, itching, and skin flaking. Nanotechnology plays an important role in advancing the cosmeceutical formulation by improving the solubility, stability, safety, loading efficiency, and dermal permeability of the active ingredients. The aim of this review is to offer a comprehensive discussion on the application of various nanomaterials in improving cosmeceutical formulations used to treat hyperpigmentation. Focus is placed on elucidating the advantages that nanotechnology can bring to some common hyperpigmentation active ingredients such as hydroquinone, arbutin, kojic acid, azelaic acid, and retinoic acid to improve their efficacy in treating hyperpigmentation. Lastly, a total of 44 reported patents and articles of depigmenting compounds encapsulated by nanoparticles were filed and analyzed. Overall, lipid nanoparticles were found to be the most widely used nanomaterial in treating hyperpigmentation. Graphical abstract

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Section: Organic Nanoparticlesmentioning

confidence: 99%

Advances in cosmeceutical nanotechnology for hyperpigmentation treatment

2022

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“…A recent proof-of-principle study also explored the potential of co-encapsulation and co-delivery of hydrophobic and hydrophilic active ingredients within the same emulsion. 107 First, a model hydrophobic active ingredient, Sudan III, was encapsulated within the SLN itself then depending on the type of emulsifier used to stabilise the SLNs, dimethylphthalate (DMP) and NaCl were encapsulated within a O/W and W/O emulsion respectively. 107 The potential for multi modal drug delivery of both hydrophobic and hydrophilic actives is a highly desirable concept, diminishing the need for multiple doses as well as offering potential synergistic benefits.…”

Section: Lipid Nanoparticlesmentioning

confidence: 99%

Recent progress in Pickering emulsions stabilised by bioderived particles

2021

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“…We also observed controlled destabilization of Pickering emulsions of dodecane or biocompatible Medium Chain Triglyceride (MCT) oils in the same conditions with slower kinetics (month scale). Furthermore, study of multi-encapsulation sites in simple Pickering emulsions or derived capsules (actives located in dispersed phase and in stabilizing particles)has been addressed only to a limited extent but has been ongoing (Beladjine, 2019;Chen et al, 2020;Sakellari et al, 2021;Schröder et al, 2020). The second encapsulation site (stabilizing agents) allows confining a substance which activity is enhanced at the interface (like antioxidants).…”

Section: Introductionmentioning

confidence: 99%