Independent Component Analysis Reveals Atypical Electroencephalographic Activity During Visual Perception in Individuals with Autism

Milne, Elizabeth; Scope, Alison; Pascalis, Olivier; Buckley, David; Makeig, Scott

doi:10.1016/j.biopsych.2008.07.017

Cited by 133 publications

(119 citation statements)

References 32 publications

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“…Aberrant detection rates and reaction times to Mooney faces were associated with a reduction of gamma-band power at the sensor level, which started as early as 80 ms with a decrease in the evoked response over occipitoparietal sensors. Previous studies examining gamma-band power in ASD during complex visual processing in ASD have reported intact evoked responses (Grice et al, 2001;Brown et al, 2005;Milne et al, 2009). The current results suggest that visual processing in ASD is associated with a pronounced deficit in feedforward, transient gamma-band activity, which is supported by event-related potential studies (Milne et al, 2009;Sutherland and Crewther, 2010).…”

Section: Discussionsupporting

confidence: 76%

“…In the auditory domain, reduced entrainment to auditory stimulation at 40 Hz in participants with ASD (Wilson et al, 2007) as well as their firstdegree relatives (Rojas et al, 2011) has been demonstrated. In contrast, during visual perception there is evidence for both hyperactivity and hypoactivity of gamma-band oscillations (Grice et al, 2001;Brown et al, 2005;Milne et al, 2009;Isler et al, 2010;Stroganova et al, 2012), raising the question of the link between high-frequency oscillations and perceptual dysfunctions in the disorder.…”

Section: Introductionmentioning

confidence: 99%

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Impaired Gamma-Band Activity during Perceptual Organization in Adults with Autism Spectrum Disorders: Evidence for Dysfunctional Network Activity in Frontal-Posterior Cortices

Sun

Grützner²,

Bölte³

et al. 2012

Journal of Neuroscience

139

134

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Current theories of the pathophysiology of autism spectrum disorders (ASD) have focused on abnormal temporal coordination of neural activity in cortical circuits as a core impairment of the disorder. In the current study, we examined the possibility that gamma-band activity may be crucially involved in aberrant brain functioning in ASD. Magneto-encephalographic (MEG) data were recorded from 13 adult human participants with ASD and 16 controls during the presentation of Mooney faces. MEG data were analyzed in the 25-150 Hz frequency range and a beamforming approach was used to identify the sources of spectral power. Participants with ASD showed elevated reaction times and reduced detection rates during the perception of upright Mooney faces, while responses to inverted stimuli were in the normal range. Impaired perceptual organization in the ASD group was accompanied by a reduction in both the amplitude and phase locking of gamma-band activity. A beamforming approach identified distinct networks during perceptual organization in controls and participants with ASD. In controls, perceptual organization of Mooney faces involved increased 60 -120 Hz activity in a frontoparietal network, while in the ASD group stronger activation was found in visual regions. These findings highlight the contribution of impaired gamma-band activity toward complex visual processing in ASD, suggesting atypical modulation of high-frequency power in frontoposterior networks.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Impaired Gamma-Band Activity during Perceptual Organization in Adults with Autism Spectrum Disorders: Evidence for Dysfunctional Network Activity in Frontal-Posterior Cortices

Sun

Grützner²,

Bölte³

et al. 2012

Journal of Neuroscience

139

134

View full text Add to dashboard Cite

show abstract

“…ICA-based approaches have been used in various EEG studies and have provided valuable insights into pathological processes. [40][41][42][43][44] Here, we will use a newly developed ICA approach that allows the estimation of group independent components (gIC). Using this approach, it is possible to disentangle between-group differences more precisely than before.…”

Section: Introductionmentioning

confidence: 99%

Resting State EEG in Children With Learning Disabilities

Jäncke

Alahmadi

2015

Clin EEG Neurosci

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In this study, the neurophysiological underpinnings of learning disabilities (LD) in children are examined using resting state EEG. We were particularly interested in the neurophysiological differences between children with learning disabilities not otherwise specified (LD-NOS), learning disabilities with verbal disabilities (LD-Verbal), and healthy control (HC) children. We applied 2 different approaches to examine the differences between the different groups. First, we calculated theta/beta and theta/alpha ratios in order to quantify the relationship between slow and fast EEG oscillations. Second, we used a recently developed method for analyzing spectral EEG, namely the group independent component analysis (gICA) model. Using these measures, we identified substantial differences between LD and HC children and between LD-NOS and LD-Verbal children in terms of their spectral EEG profiles. We obtained the following findings: (a) theta/beta and theta/alpha ratios were substantially larger in LD than in HC children, with no difference between LD-NOS and LD-Verbal children; (b) there was substantial slowing of EEG oscillations, especially for gICs located in frontal scalp positions, with LD-NOS children demonstrating the strongest slowing; (c) the estimated intracortical sources of these gICs were mostly located in brain areas involved in the control of executive functions, attention, planning, and language; and (d) the LD-Verbal children demonstrated substantial differences in EEG oscillations compared with LD-NOS children, and these differences were localized in language-related brain areas. The general pattern of atypical neurophysiological activation found in LD children suggests that they suffer from neurophysiological dysfunction in brain areas involved with the control of attention, executive functions, planning, and language functions. LDVerbal children also demonstrate atypical activation, especially in language-related brain areas. These atypical neurophysiological activation patterns might provide a helpful guide for rehabilitation strategies to treat the deficiencies in these children with LD.

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“…One study employed the Vistech wall chart, where participants indicated the orientation of gratings that decreased in contrast, at the following spatial frequencies: 1.5, 3, 6, 12 and 18 cycles/degree (cpd) (de Jonge, et al, 2007). The other study employed the CSV-1000, where participants indicated which of two patches contained a grating stimulus across a range of contrasts, at the following spatial frequencies: 3, 6, 12 and 18 cpd (Milne, Scope, Pascalis, Buckley, & Makeig, 2009). However, as mentioned above for clinical screening charts that measure visual acuity, those measuring contrast sensitivity are considered to be quick assessments, developed for monitoring contrast sensitivity of clinical patients whose conditions (e.g., glaucoma, cataracts, etc) result in large deterioration of visual abilities.…”

mentioning

confidence: 99%

Spatial Contrast Sensitivity in Adolescents with Autism Spectrum Disorders

Koh

Milne

Dobkins

2010

J Autism Dev Disord

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Adolescents with Autism Spectrum Disorders (ASD) and typically developing (TD) controls underwent a rigorous psychophysical assessment that measured contrast sensitivity to seven spatial frequencies (0.5 to 20 cycles/degree). A contrast sensitivity function (CSF) was then fitted for each participant, from which four measures were obtained: visual acuity, peak spatial frequency, peak contrast sensitivity, and contrast sensitivity at a low spatial frequency. There were no group differences on any of the four CSF measures, indicating no differential spatial frequency processing in ASD.Although it has been suggested that detail-oriented visual perception in individuals with ASD may be a result of differential sensitivities to low vs. high spatial frequencies, the current study finds no evidence to support this hypothesis.

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Independent Component Analysis Reveals Atypical Electroencephalographic Activity During Visual Perception in Individuals with Autism

Cited by 133 publications

References 32 publications

Impaired Gamma-Band Activity during Perceptual Organization in Adults with Autism Spectrum Disorders: Evidence for Dysfunctional Network Activity in Frontal-Posterior Cortices

Impaired Gamma-Band Activity during Perceptual Organization in Adults with Autism Spectrum Disorders: Evidence for Dysfunctional Network Activity in Frontal-Posterior Cortices

Resting State EEG in Children With Learning Disabilities

Spatial Contrast Sensitivity in Adolescents with Autism Spectrum Disorders

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